Universiteit Leiden

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Medical Biochemistry

Projects

Research projects

At Medical Biochemistry in collaboration with Bio-Organic Synthesis, LIC

  • Analytical chemistry and biochemistry of glycosphingolipids ( M. Mirzaian)
  • Impact of LIMP-2 deficiency on lysosomal glucocerebrosidase (P. Gaspar)
  • Lysosomal proteases: a target for Gaucher disease treatment? ( S. Oussoren)
  • Endogenous and recombinant human alpha-galactosidase produced in plants ( K. Kytidou)
  • Glycosphingolipids and Metabolic Syndrome ( M. van Eijk)
  • Zebra fish models of LSDs: screening for therapeutic agents ( W. Kallemeijn & L. Lelieveld)
  • Pluripotent stem cells and investigations on lysosomal storage disease ( R. Boot)
  • Sphingolipid-based chemical biology probes ( P. Haberkant)
  • Intracellular sorting mechanisms for lysosomal proteins ( E. van Meel)
  • Novel metabolites formed by transglycosylation
  • Activity-based probes for lysosomal glycosidases in biomedical research ( C-L. Kuo)

At Bio-Organic Synthesis (Prof. H.S. Overkleeft)

  • Synthesis of labeled complex glycosphingolipids ( P. Wisse)
  • Design and synthesis of glycosidase activity based probes ( J. Jiang)
  • Design and synthesis of glycosyltransferase inhibitors ( T. Beenakker)
  • Iminosugars as glycosidase inhibitors ( B. Liu)

At Macromolecular Biochemistry (Prof. M. Ubbink)

Still ongoing at AMC and NIN, Amsterdam

  • Gba2 as target for pharmacological intervention in Niemann Pick type C (A. Marques)
  • Bitter iminosugars and hypothalamic regulation of metabolism (D. Herrera Moro)
  • Lysosomal stress and metabolic syndrome (T. Gabriel)
  • Biochemical investigations on Fabry disease (M.J. Ferraz)
  • Protein biomarkers for ovary cancer (W. Wegdam)
  • BAR proteins in Candida albicans (A. Gkoursta)
  • Cell biological aspects of IDOL (J.K. Nelson)