Systems pharmacology-based translational drug pharmacokinetics
High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.
- Elke Krekels
Within these screens, characterized by small sample volumes, knowledge on the pharmacokinetics and drug exposure is limited. Information on exposure is however vital for the establishment of a concentration-effect relationship and for interspecies scaling.
The objective of this project is to integrate state-of-the-art techniques like ultrasensitive LCMS, and non-linear mixed effects modelling, to characterize drug disposition through various pathways in species used in high-throughput screens. This project is a collaboration between the Systems Pharmacology cluster of the Leiden Academic Centre for Drug Research (LACDR), and the Institute of Biology Leiden (IBL).