Research output
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Publication Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication Kv 11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical Kv 11.1 (hERG) inhibitors
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication Sodium ion binding pocket mutations and adenosine A2A receptor function
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication A community computational challenge to predict the activity of pairs of compounds
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication A document classifier for medicinal chemistry publications trained on the ChEMBL corpus
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication A community effort to assess and improve drug sensitivity prediction algorithms
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science
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Publication A yeast screening method to decipher the interaction between the adenosine A2B receptor and the C-terminus of different G protein α-subunits.
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Cell Systems and Drug Discovery
- Medicinal Chemistry
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Science