Research output

• Stereoelectronic and conformational effects in oxocarbenium, iminium and iminosugar ammonium ions

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Bio-organic Synthesis

  

• Pharmacogenomics in drug development: implementation and application of PKPD model based approaches

  Dissertation

  • Science
    • Leiden Academic Centre for Drug Research (LACDR)
    • Systems Pharmacology and Pharmacy

  

• Macrophage activation and cholesterol accumulation in atherosclerosis development

  Dissertation

  • Science
    • Leiden Academic Centre for Drug Research (LACDR)
    • BioTherapeutics
    • Cardiovascular and Metabolic Therapeutics

  

• Cutaneous barrier dysfunction in atopic eczema: the role of stratum corneum lipids

  Publication

  • Science
    • Leiden Academic Centre for Drug Research (LACDR)
    • BioTherapeutics

• Lipid chain length reduction correlates with the skin barrier function in atopic eczema patients and inflammation plays a role in the altered epidermal lipid biosynthesis

  Publication

  • Science
    • Leiden Academic Centre for Drug Research (LACDR)
    • BioTherapeutics

• Rationally designed peptide based functional biomaterials

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Supramolecular & Biomaterials Chemistry

  

• Poly-(lactic-co-glycolic-acid)-based particulate vaccines: particle uptake by dendritic cells is a key parameter for immune activation

  Publication

  • Science
    • Leiden Academic Centre for Drug Research (LACDR)
    • BioTherapeutics

• Coiled-coils on lipid membranes: a new perspective on membrane fusion

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Supramolecular & Biomaterials Chemistry

  

• Casting light on the ƞ Carinae puzzle

  Dissertation

  • Science
    • Leiden Observatory

  

• Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing

  Dissertation

  • Science
    • Leiden Academic Centre for Drug Research (LACDR)
    • Cell Systems and Drug Safety
    • Cancer Therapeutics and Drug Safety

  

• Exploring the potentials of nurture: 2(nd) and 3(rd) generation explant human skin equivalents

  Publication

  • Science
    • Leiden Academic Centre for Drug Research (LACDR)
    • BioTherapeutics

• Zipping into Fusion

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Supramolecular & Biomaterials Chemistry

  

• Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier

  Dissertation

  • Science
    • Leiden Academic Centre for Drug Research (LACDR)
    • BioTherapeutics
    • Biologics Formulation

  

• Structural Health Monitoring Meets Data Mining

  Dissertation

  • Science
    • Leiden Institute of Advanced Computer Science (LIACS)

  

• Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists

  Publication

  • Science
    • Leiden Academic Centre for Drug Research (LACDR)
    • Cell Systems and Drug Safety
    • Medicinal Chemistry