Research output
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Publication When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Drug Discovery & Safety
- Medicinal Chemistry
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Science
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Publication Variation in fatty acid chain length distribution affects permeability barrier function of stratum corneum lipid model membranes
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- BioTherapeutics
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Science
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Publication Reduced stratum corneum lipid chain length relates to an impaired skin barrier function in patients with atopic dermatitis
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- BioTherapeutics
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Science
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Publication Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Drug Discovery & Safety
- Medicinal Chemistry
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Science
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Publication Cutaneous barrier dysfunction in atopic eczema: the role of stratum corneum lipids
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- BioTherapeutics
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Science
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Publication Lipid chain length reduction correlates with the skin barrier function in atopic eczema patients and inflammation plays a role in the altered epidermal lipid biosynthesis
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- BioTherapeutics
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Science
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Publication Poly-(lactic-co-glycolic-acid)-based particulate vaccines: particle uptake by dendritic cells is a key parameter for immune activation
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- BioTherapeutics
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Science
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Publication Exploring the potentials of nurture: 2(nd) and 3(rd) generation explant human skin equivalents
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- BioTherapeutics
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Science
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Publication Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Drug Discovery & Safety
- Medicinal Chemistry
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Science
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Publication Kv 11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical Kv 11.1 (hERG) inhibitors
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Drug Discovery & Safety
- Medicinal Chemistry
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Science
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Publication An ex vivo human skin model for studying skin barrier repair
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- BioTherapeutics
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Science
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Publication Sodium ion binding pocket mutations and adenosine A2A receptor function
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Drug Discovery & Safety
- Medicinal Chemistry
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Science
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Publication Cationic liposomes loaded with a synthetic long Peptide and poly(i:C): a defined adjuvanted vaccine for induction of antigen-specific T cell cytotoxicity
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- BioTherapeutics
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Science
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Publication A community computational challenge to predict the activity of pairs of compounds
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- Drug Discovery & Safety
- Medicinal Chemistry
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Science
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Publication Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
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Science
- Leiden Academic Centre for Drug Research (LACDR)
- BioTherapeutics
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Science