PhD defence
The Use of 3D Skin Equivalents Mimicking Skin Cancers
- S. Wu
- Date
- Thursday 12 March 2026
- Time
- Location
-
Academy Building
Rapenburg 73
2311 GJ Leiden
Supervisor(s)
- Prof.dr. M.H. Vermeer
- dr. A. El Ghalbzouri
Summary
The research presented in this thesis demonstrated multidisciplinary cooperation among Oncology, Bioengineering, Nanomedicine, and Pharmacology. This work aims to elucidate aspects of Cancer-associated fibroblast (CAF) heterogeneity using 3D human skin equivalents (HSEs) that mimic different types of skin (epithelial) cancers, and to examine the potential of 3D HSEs for drug efficacy evaluation, with a particular focus on tumor-stroma interactions. In this research, we identified specific CAF precursor cells, and explored different CAF-targeted therapeutics by using our 3D HSE system. Our work could provide a stable modeling platform for future tumor-stroma interaction studies, and help to discover new therapeutics for skin cancer patients in the future.
PhD dissertations
Approximately one week after the defence, PhD dissertations by Leiden PhD students are available digitally through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.
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General information
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