PhD defence
The Branching of Life: Human iPSC-Based Angiogenesis-on-Chip
- K.E. Urdaneta González
- Date
- Tuesday 17 February 2026
- Time
- Location
-
Academy Building
Rapenburg 73
2311 GJ Leiden
Supervisor(s)
- Prof.dr. C.L. Mummery
- dr. V.V. Orlova
Summary
This thesis brings blood vessel growth to life on a chip, using human stem cell–derived endothelial cells to recreate the branching of human vasculature in a controlled 3D microenvironment. The model reveals how vessels respond to anti-angiogenic drugs and opens a window into patient-specific vascular disease through stem cells from individuals with Hereditary Hemorrhagic Telangiectasia. By uniting engineering, stem cell biology, and medicine, this work provides a human-relevant platform for exploring vascular development and discovering new therapies.
PhD dissertations
Approximately one week after the defence, PhD dissertations by Leiden PhD students are available digitally through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.
Press enquiries (journalists only)
General information
Beadle's Office
pedel@bb.leidenuniv.nl
+31 71 527 7211