Universiteit Leiden

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PhD defence

Diversity of glucocorticoid signaling

  • E.M.G. Viho
Thursday 7 September 2023
Academy Building
Rapenburg 73
2311 GJ Leiden


  • Prof.dr. O.C. Meijer
  • dr. J. Kroon


From an evolutionary perspective, stress is an adaptive system that is necessary to
generate appropriate responses to stochastic and unpredictable events, and cope
accordingly with the environment. The physiological response to stress has been
remarkably conserved in vertebrate evolution. However, the threats to our
internal “equilibrium” have changed between our ancestral environments and our
current modern societies, and the demands for survival have evolved. The
glucocorticoid receptor (GR) is a timeless component of stress adaptation, as it is at
the intersection between the environmental stressors (i.e., physical, or psychosocial)
and the genome. Therefore, the GR represents a valuable therapeutic target in
stress- and glucocorticoid-related disorders. This thesis provides new insights
into the molecular mechanisms underlying GR signaling in metabolic diseases and
brain function and highlights the promise and importance of selectivity in novel GR
targeting treatments.

PhD dissertations

Approximately one week after the defence, PhD dissertations by Leiden PhD students are available digitally through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.

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