Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
- O. Iendaltseva
- Tuesday 15 November 2022
2311 GJ Leiden
Pericytes, the mural cells of blood microvessels, are important regu- lators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms. Their disfunction has been implicated in several pathologies, including cerebral ischemia, Alzheimer’s disease and diabetic retinopathy.
To reveal mechanisms used by pericytes for mechanical interactions within microvessels we designed models bringing human induced pluripotent stem cell (hiPSC)-derived pericytes in contact with various micro- patterned substrates representing the microvascular basement membrane organization. Our findings shed light on how pericytes can mechanically regulate microvascular morphogenesis and function, and open possibilities for testing therapeutic strategies.
- Prof. T. Schmidt
- Prof. E.H.J. Danen
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