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Programme

Metabolomics as a tool to investigate natural products 

10:00 – 11:00 Introduction to metabolomics (Robert Verpoorte) 
11:00 – 12:30 Application of metabolomics to medicinal plant research (Alvaro Viljoen)
12:30 – 14:00 Break
14:00 – 15:30 Metabolomics in human health and disease (Martin Giera)
15:30 – 16:30 Revisiting Traditional Chinese Medicine by Metabolomics (Mei Wang)

How to extract and basic of data processing and multivariate data analysis

10:00 – 11:00 Sample preparation (Hye Kyong Kim)
11:00 – 12:30 Basic chromatography theory for metabolomics (Erica G. Wilson)
12:30 – 14:00 Break
14:00 – 15:00 Basic of multivariate data analysis (Harald van Mil)
15:00 – 16:00 Chromatography and spectroscopy data processing for metabolomics (Jeroen Jansen)

How to detect metabolites by chromatography and spectroscopy

10:00 – 11:30 Gas Chromatography-based metabolomics: theory and applications (Joachim Kopka)
11:30 –  13:00 LC-MS Metabolomics: theory and applications (J. William Allwood)
13:00 –  14:00 Break
14:00 –  15:00 TLC application to medicinal plant metabolic fingerprinting (Tien Do)
15:00 –  16:30 NMR based metabolomics: theory and applications to food analysis (Jan Schripsema)

Metabolomics applications in life sciences

10:00 – 11:00 NMR-based profiling of intra – and extracellular metabolome (Sarantos Kostidis)
11:00 – 12:30 11:00 – 12:30 Strategies for unambiguous identification of biomarkers (Jean-Luc Wolfender)
12:30 – 14:00 Break
14:00 – 15:00 14:00 – 15:00 NMR-based profiling of intra – and extracellular metabolome (Sarantos Kostidis)
15:00 – 16:30 Metabolomics applications in agriculture and marine research (David Overy)

Techniques in detail 

 10:00 – 11:00 Ambient mass spectrometry applied in food safety, metabolomics, forensics and drug analysis (Teris van Beek)
11:00 – 12:00 Identification of Metabolites by MS spectrometry (Rob van der Heijden)
12:00 – 14:00 Break
14:00 - 15:00 Application of in-vivo NMR for plant physiology (François Mesnard)
15:00-16:00 Closing Remarks (Robert Verpoorte, Young Hae Choi)

Easter holiday

LC-MS and NMR Measurements

11:00 – 12:00 Sample Preparation and Extraction (pre-record Video)
12:00 – 12:30 Q & A for sample preparation and extraction
14:00 – 15:00 LC-MS and NMR measurements (pre-record Video)
15:00 – 16:00 Q & A for LC-MS and NMR measurements

Data processing of LC-MS

11:00 – 12:00 LC-MS data processing (Lina M. Bayona Maldonado)
12:00 – 12:30 Q & A for LC-MS data processing
14:00 – 15:00 NMR data processing based on Mnova NMR suite (Young Hae Choi)
15:00 – 15:30 Q & A for NMR data processing

Identification by LC-MS and multivariate data analysis

 11:00 – 12:00 MetaboScape (Bruker) application to LC-MS metabolomics (Rob van der Heijden)
12:00 – 12:30 Q & A for the application of MetaboScape
 14:00 – 15:00 Multivariate data analysis (PCA and PLS) based on SIMCA (Young Hae Choi)
15:00 – 15:30 Q & A for Multivariate data analysis

Discussion

 10:00 – 13:00 Discussion the homework of multivariate data analysis (Young Hae Choi)

Structural elucidation of amino acids I

 10:00 – 12:00 Structural elucidation of amino acids I-1 (Young Hae Choi)
14:00 – 16:00 Structural elucidation of amino acids I-2 (Young Hae Choi)

Structural elucidation of amino acids II

 10:00 – 12:00 Structural elucidation of amino acids II-1 (Young Hae Choi)
14:00 – 16:00 Structural elucidation of amino acids II-2 (Young Hae Choi)

Structural elucidation of amino acids III

 10:00 – 12:00 Structural elucidation of amino acids III-1 (Young Hae Choi)
14:00 – 16:00 Structural elucidation of amino acids III-2 (Young Hae Choi)

15 April, 2021 (Thursday)

Structural elucidation of sugars-I

 10:00 – 12:00 Structural elucidation of sugars I-1 (Young Hae Choi)
14:00 – 16:00 Structural elucidation of sugars I-1 (Young Hae Choi)

Structural elucidation of sugars-II

 10:00 – 12:00 Structural elucidation of sugars II-1 (Young Hae Choi)
14:00 – 16:00 Structural elucidation of sugars II-1 (Young Hae Choi)
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