Research project
Molecular mechanisms of organ toxicity
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- Duration
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- Contact
- Bob van de Water
We use a combination of transgenic mouse models, three-dimensional in vitro organoid culture, transcriptomics and functional genomics to unravel the mechanisms of toxicity in the liver and kidney - organs which are particularly susceptible to adverse drug reactions. The role of signalling by Toll-Like Receptors (TLRs) and the immune response in stress responses in the kidney are of specific interests here. From a mechanistic viewpoint, there are similarities in the responses observed in kidney epithelial cells during ischemia-reperfusion injury. We are studying the role of cell adhesion in the modulation of ischemic stress responses and cytotoxicity and more specifically at the role of the tyrosine kinase FAK in knockout mose models of ischemia.
Related research
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Molecular mechanisms of organ toxicity
- Functional genomics to unravel signaling pathways that mediate drug-induced liver injury (DILI).
- Functional genomics of kidney epithelial cell regeneration
- The effect of enhancing cell adhesion by Epac activation on the prevention and repair of ischaemic renal tubule injury
- TLR signalling in Nephrotoxicity
- The effect of enhancing cell adhesion on the prevention of nephrotoxicity-induced acute renal failure
- The role of focal adhesion kinase (FAK) in ischaemic renal injury and regeneration