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Publication highlights

Research articles


2021

Ultee, E., Zhong, X., Shitut, S., Briegel, A. and Claessen, D. Formation of wall-less cells in Kitasatospora viridifaciens requires cytoskeletal protein FilP in oxygen-limiting conditions. Mol Microbiol. doi: 10.1111/mmi.14662.

Zhang, L. Ramijan, K., Carrión, V.J., van der Aart, L.T., Willemse, J., van Wezel, G.P. and Claessen, D. A novel and conserved cell wall enzyme that can substitute for the Lipid II synthase MurG biorXiv. doi: 10.1101/2020.10.12.336396

Henneman, B., Brouwer, T.B., Erkelens, A.M., Kuijntjes, G.J., van Emmerik, C., van der Valk, R.A., Timmer, M., Kirolos, N.C.S., van Ingen, H., van Noort, J. and Dame, R.T. Mechanical and structural properties of archaeal hypernucleosomes. Nucleic Acids Res. doi: 10.1093/nar/gkaa1196.

 

2020

Kloosterman, A.M., Cimermancic, P., Elsayed, S.S., Du, C., Hadjithomas, M., Donia, M.S., Fischbach, M.A., van Wezel, G.P. and Medema, M.H. Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides. PLoS Biol.18(12):e3001026. doi: 10.1371/journal.pbio.3001026.

Zhang, Z., Du, C., de Barsy, F., Liem, M., Liakopoulos, A., van Wezel, G.P., Choi, Y.H., Claessen, D. and Rozen, D.E. Antibiotic production in Streptomyces is organized by a division of labor through terminal genomic differentiation. Sci Adv. 6(3):eaay5781. doi: 10.1126/sciadv.aay5781.

Muok, A.R., Ortega, D.R., Kurniyati, K., Yang, W., Maschmann, Z.A., Mabrouk, A.S., Li, C., Crane, B.R. and Briegel, A. Atypical chemoreceptor arrays accommodate high membrane curvature. Nature Comm. 11(1):5763. doi: 10.1038/s41467-020-19628-6.

Oliveira Paiva, A.M., van Eijk, E., Friggen, A.H., Weigel, C. and Smits, W.K. Identification of the Unwinding Region in the Clostridioides difficile Chromosomal Origin of Replication. Front Microbiol. 11:581401. doi: 10.3389/fmicb.2020.581401.

Dodd, T., Botto, M., Paul, F., Fernandez-Leiro, R., Lamers, M.H. and Ivanov, I. Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path. Nature Comm. 11(1):5379–11. doi: 10.1038/s41467-020-19165-2.

Boekhoud, I.M., Hornung, B.V.H., Sevilla, E., Harmanus, C., Bos-Sanders, I.M.J.G., Terveer, E.M., Bolea, R., Corver, J., Kuijper, E.J. and Smits W.KPlasmid-mediated metronidazole resistance in Clostridioides difficile. Nature Comm. 11(1):598. doi: 10.1038/s41467-020-14382-1.

Qin, L., Bdira, F.B., Sterckx, Y.G.J., Volkov, A.N., Vreede, J., Giachin, G., van Schaik, P., Ubbink, M. and Dame, R.TStructural basis for osmotic regulation of the DNA binding properties of H-NS proteins. Nucleic Acids Res. 48(4):2156-2172. doi: 10.1093/nar/gkz1226.

 

2019

van Eijk E., Boekhoud .IM., Kuijper E.J., Bos-Sanders I.M.J.G., Wright G. and Smits W.KGenome Location Dictates the Transcriptional Response to PolC Inhibition in Clostridium difficileAntimicrob. Agents Chemother. 63(2). pii: e01363-18. doi: 10.1128/AAC.01363-18.

Oliveira Paiva, A.M., Friggen, A.H., Qin L., Douwes, R., Dame, R.T. and Smits W.KThe Bacterial Chromatin Protein HupA Can Remodel DNA and Associates with the Nucleoid in Clostridium difficile. J. Mol. Biol. 431(4):653-672. doi: 10.1016/j.jmb.2019.01.001.

Wu, C., van der Heul, H.U., Melnik, A.V., Luebben, J., Dorrestein, P.C., Minnaard, A.J., Choi, Y.H. and van Wezel, G.P. Lugdunomycin, an angucycline-derived molecule with unprecedented chemical architecture. Angew. Chem. Int. Ed. Engl. doi:10.1002/anie.201814581.

 

2018

Dissel, D., Willemse, J., Zacchetti, B., Claessen, D., Pier, G.B., and van Wezel, G.P. Production of poly-beta-1,6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by Streptomyces. Microb. cell 5: 269-279.

Henneman, B., van Emmerik, C.L., van Ingen, H. and Dame, R.T.
Structure and function of archaeal histones. PLOS Gen. 14(9):e1007582. doi: 10.1371/journal.pgen.1007582.

Ramijan, K, E. Ultee, J. Willemse, Z. Zhang, J.A.J. Wondergem, A. van der Meij, D. Heinrich, A. Briegel, G.P. van Wezel & D. ClaessenStress-induced formation of cell wall-deficient cells in filamentous actinomycetes. Nature Comm. 9: 5164.

Yang, W., Alvarado, A., Glatter, T., Ringgaard, S., and Briegel, A.
Baseplate variability of Vibrio choleraechemoreceptor arrays, Proc. Natl. Acad. Sci. USA. 115, 13365-13370.

 

2017

Baños-Mateos, S., van Roon, A.-M.M., Lang, U.F., Maslen, S.L., Skehel, J.M. and Lamers, M.H. High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center. Nature Comm. 8(1): 855. 

Fernandez-Leiro, R., Conrad, J., Yang, J.-C., Freund, S.M.V., Scheres, S.H.W. and Lamers, M.H. Self-correcting mismatches during high-fidelity DNA replication. Nature Struct. Mol. Biol. 24(2): 140–3. 

van der Valk, R.A, Vreede, J., Moolenaar, G.F., Hofmann, A., Goosen, N. and Dame, R.T. Environmentally driven conformational changes modulate the function of H-NS.  eLife. 6: 27369.

Zhao, G., Gleave, E.S. and Lamers, M.H. Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis. eLife. 6: 32177. 

 

2016

Briegel, A., Ortega, D. R., Mann, P., Kjaer, A., Ringgaard, S., and Jensen, G. J. Chemotaxis cluster 1 proteins form cytoplasmic arrays in Vibrio choleraeand are stabilized by a double signaling domain receptor DosM Proc. Natl. Acad. Sci. USA. 113, 10412-10417.

Celler, K., Koning, R.I., Willemse, J., Koster, A.J. and van Wezel, G.P. Cross-membranes orchestrate compartmentalization and morphogenesis in Streptomyces. Nature Communications 7: 11836.

Petrus, M.L.C., E. Vijgenboom, A.K. Chaplin, J.A.R. Worrall, G.P. van Wezel and Claessen, D. The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces. Open Biology 6: 150149.

Zacchetti, B., Willemse, J., Recter, B., van Dissel, D., van Wezel, G.P., Wösten, H.A.B. and Claessen, D. Aggregation of germlings is a major contributing factor towards mycelial heterogeneity of Streptomyces. Scientific Reports 6: 27045.

 

Authoritative review articles


Yang, W. and Briegel, ADiversity of Bacterial Chemosensory Arrays. Trends Microbiol. 2020.28(1):68-80. doi: 10.1016/j.tim.2019.08.002. 

Dame, R.T., Rashid, F.M. and Grainger, D.CChromosome organization in bacteria: mechanistic insights into genome structure and function. Nature Reviews Gen. 2020. doi: 10.1038/s41576-019-0185-4.

Claessen, D. and Errington, J. Cell Wall Deficiency as a Coping Strategy for Stress. Trends Microbiol. 2019. 27(12):1025-1033. doi: 10.1016/j.tim.2019.07.008.

Ultee, E., Ramijan, K.,  Dame, R.T., Briegel, A. and Claessen, DStress-induced adaptive morphogenesis in bacteria. Adv. Microb. Physiol. 2019. 74:97-141. doi: 10.1016/bs.ampbs.2019.02.001.

Smits, W.K., Lyras, D., Lacy, D.B., Wilcox, M.H. and Kuijper, E.J. Clostridium difficile infection. Nature Reviews Dis Primers. 2016. 2:16020. doi: 10.1038/nrdp.2016.20

Driessen, R.P.C., Peeters, E., Werner, F. and Dame, R.T. The interplay between nucleoid organization and transcription in archaeal genomes. Nature Reviews Microbiol. 2015. 13(6), 333-341.

Claessen, D., Rozen, D.E., Kuipers, O.P., Søgaard-Andersen, L. and G.P. van Wezel.  Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies. Nature Reviews Microbiol. 2014.  12: 115-124.

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