Leiden University logo.

nl en


The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends across length scales facilitating an understanding of structure-function relationships at both the molecular and the cellular level. This naturally combines approaches from biochemistry, biophysics, cell biology, structural biology and genetics.

Structure and function of proteins, nucleic acids and protein-nucleic acid complexes

  • Atomic force microscopy
  • NMR
  • TIRF microscopy
  • Tethered Particle Motion
  • Magnetic tweezers
  • Optical tweezers
  • Topological analysis
  • Rigid base pair Monte Carlo simulations
  • Statistical physics modelling

Genomics and proteomics

  • ChIP-seq
  • RNA-seq
  • Chromosome Conformation Capture (3C, HiC)
  • Nanopore sequencing

Structure and morphology of cells, intracellular dynamics

  • TIRF microscopy
  • Confocal microscopy
  • Multi-focus 2-Photon microscopy
  • Fluorescence Correlation Spectroscopy
This website uses cookies.