Programme

Sunday 15th June 2025

TIME	SCHEDULE
12:00	Registration Lounge area 2 Chaired by: Isabel Nuñez
16:00	Welcome ceremony Zuiderduinzaal Chairs: Gilles van Wezel and Evi Stegmann
17:00	Keynote presentation - Pieter Dorrestein Scaling The Discovery of New Microbial Natural Products Through Data Science of Unused Metabolomics Data Zuiderduinzaal Chair: Eung-Soo Kim
18:00	Welcome Reception Lounge area 2

Monday 16th June 2025

TIME	SCHEDULE
08:45	Plenary 1 - Anne Marie Wehenkel Mechanistic Insights into Polar Growth and Cell Division Coordination in Mycobacteriales Zuiderduinzaal Chair: Marie Elliot
09:50	Session 1 *Development and Growth* Zuiderduinzaal Chairs Dennis Claessen Dagmara Jakimowicz	Session 2 *Phylogenomics and Taxonomy* Abdijzaal Chairs Martha Trujillo Wen-Jun Li
09:50	Yasuo Ohnishi: The lack of cell wall-anchored hydrophobic proteins induces exploratory growth in Actinoplanes missouriensis	Hilal Ay: Novel Actinomycetota species from Antarctica: Phylogenomics and Taxonomy
10:20	Susan Schlimpert: Structural and Functional Characterisation of a Conserved Cell Division Factor in Actinobacteria	Imen Nouiou: Modern Polyphasic Taxonomy and Natural Products of Actinobacteria
10:50	Break Lounge area 2
11:15	Jana K Schniete: Lipid-based storage compounds in Streptomyces and their impact on cell differentiation and stress response	Wenjun Li: Exploration of Novel Lineages and Carbon Fixation Pathways in Actinomycetota: Insights from Multi-Omics
11:35	Marcin Szafran: The Dual Pathway to Chromosome Compaction: How SMC Condensin and the Unique Histone-like Protein HupS Cooperate during Streptomyces Spore Formation	Natalie Millán-Aguiñaga: Marine Actinobacteria from Extreme Environments in Baja California: Isolation and Potential Applications
11:55	Klas Flärdh: The polar organelle that directs growth in streptomycetes	Vartul Sangal: Phylogenomic structure of new actinobacterial genus Rhodococcoides
12:15	Lunch Lounge area 2
13:15	Plenary 2 - Zixin Deng DNA Modification by Sulfur: Mechanistic Insights Drives Synthetic Biotechnologies Forward Zuiderduinzaal Chair: Lixin Zhang
14:15	Flashtalk session 1 Zuiderduinzaal Refactoring at high throughput silent biosynthetic gene clusters from Actinomycetes shuttled in E. coli Evita Dollon Discovery of a Novel Tricyclic-Acetal-Lactone: Structural Echoes of Echinosporin and Unfolding Clues to a Shikimate Biosynthesis Matthias Klees A beach microbiome: On the possible ecological role of actinomycetes in a turtle nesting area Jonathan Parra Unveiling the regulation of arabinose metabolism in Streptomyces coelicolor Augustin Rigolet DESI-MS: A Multi-Scale Analytical Tool for Detecting Chemical Diversity in Streptomyces and Microbial Ecosystems Golsa Nayeb Ghanbar Hosseini Friends with benefits: Tropical ant-associated Streptomyces Bonnie Whatmough Multicellular strategies of Streptomyces for inactivating free phage particles Moses Kabuu
14:30	Break Lounge area 2
14:45	Session 3 *Synthetic Biology and Genetics* Zuiderduinzaal Chairs Lixin Zhang Tilmann Weber	Session 4 *Genomics and Natural Products Biosynthesis* Abdijzaal Chairs Nadine Ziemert Marnix Medema
14:45	Dagmara Jakimowicz: Seeing is Understanding: How Cell Biology Complements Chromosomal Contact Mapping in Streptomyces	Jaclyn Winter: Bioprospecting Hypersaline Microorganisms from Great Salt Lake for Natural Product Discovery and Environmental Adaptation
15:15	Hahk-Soo Kang: Strain Optimization for High-titer and Selective Production of Natural Products	Eric Helfrich: Artificial Intelligence-based Expansion of Natural Product Biosynthetic Space
15:45	Break Lounge area 2
16:15	Sylvie Lautru: Learning from the refactoring of the congocidine biosynthetic pathway	Lisa Vader: Predicting products of terpene biosynthetic gene clusters with antiSMASH
16:35	Xiaozhou Luo: AutoStrep: An Automated Platform for High-Throughput Streptomyces Engineering and Gene Function Exploration	Lei Dong: Unlocking the Potential of Desert Actinomycetes: A Journey from Diversity Assessment to Cultivation and Application Prospects
16:55	Claire Bertrand: Bridging mismatch repair, double strand break repair, and genome plasticity in Streptomyces	Kai Blin: What's new in antiSMASH 8 & the antiSMASH ecosystem
17:15	Poster Session 1 Odd Numbers The Ritz

Tuesday 17th June 2025

TIME	SCHEDULE
08:45	Plenary 3 - Kira Weissman Decision making in polyketide biosynthesis Zuiderduinzaal Chair: Christine Beemelmanns
09:50	Session 5 *Natural Products Discovery and Biosynthesis* Zuiderduinzaal Chairs Bradley Moore Christine Beemelmanns	Session 6 *Primary metabolism and its connection with secondary metabolism* Abdijzaal Chairs Evi Stegmann Kenji Ueda
09:50	Ben Shen: The Actinobacteria Strain Collection and Genome Database at NPDC as a Community Resource for Natural Products Research	Takeshi Hosaka: Concentration-dependent effects of ribosome-targeting antibiotics on actinomycete growth and secondary metabolism
10:20	Ling Ding: Plant growth promoting metabolites from Streptomyces	Hyun Uk Kim: Computational approaches for enhancing secondary metabolite production in Streptomyces
10:50	Break Lounge area 2
11:15	Katherine Duncan: Modulating Rhodococcus and Micromonospora Metabolism via Temperature and Salinity	Sebastien Rigali: COMMBAT: Signaling pathways prediction tool from environmental nutrients to BGC expression
11:35	Manoj Jangra: Discovery and biosynthesis of lariocidin: a first-in-class lasso peptide antibiotic targeting the bacterial ribosome	Paul Straight: Cellular organization of enzymatic complexes for antibiotic biosynthesis and export
11:55	Tohru Dair: Peptide epimerases responsible for biosynthesis of natural products produced by actinomycetes	Fumihito Hasebe: Discovery of a novel methionine biosynthetic route in Streptomyces
12:15	Student - Mentor lunch Lounge area 2 Chair: Prof. Evi Stegmann
13:15	Plenary 4 - Lone Gram Tropodithietic acid – a multifunctional bacterial secondary metabolite Zuiderduinzaal Chair: Paul Hoskisson
14:15	Flashtalk Session 2 Zuiderduinzaal From Petri Dishes to Soil: Streptomyces on the Hunt for Antimicrobials and Beyond Alejandra Diaz de Aguinaga Development of an integrated platform combining in vitro screening and bioproduction for the creation of bioactive RiPPs based on lactazole biosynthesis Shinta Ijichi Defining the minimal requirements for polar growth in filamentous Actinobacteria Maarten Lubbers Nocardiopsis bonnevillensis: A novel type strain and first mycolic acid-producing organism outside of the order Mycobacteriales Abigail Scott The impact of gene conversion on natural product biosynthesis Paula Thiel Pizarro The transcriptional architecture of bacterial biosynthetic gene clusters Silvia Ribeiro Monteiro
14:30	Break Lounge area 2
14:45	Session 7 *Industrial Applications and Biotechnology* Zuiderduinzaal Chairs Paul Hoskisson Olga Genilloud	Session 8 *Actinobacterial Interactions* Abdijzaal Chairs Cameron Currie Arinthip Thamchaipenet
14:45	Cuauhtemoc Licona-Cassani: Exploring nutritional shifts in industrial strains and their impact on metabolite production	Paul R. Jensen: Actinobacterial compounds and their ecological functions in marine sediments
15:15	Daniel Oves: Exploiting large actinomycete strain collections for the discovery of new anti-infective natural products	Matthew Hutchings: Streptomyces bacteria as plant growth promoters, a cautionary tale
15:45	Break Lounge area 2
16:15	Nataliia V. Machushynets: How to find a needle in a haystack? nanoRAPIDS platform for antibiotic discovery	Arinthip Thamchaipenet: Pseudonocardia persistently associated with Wolffia globosa and reveals potential active vitamin B12 production
16:35	Paul Hoskisson	Francisco Barona-Gómez: Streptomyces – Streptomyces interactions at the population level: a new frontier for chemical diversification
16:55	James Croxford: Using bar-seq to understand the genome dynamics of Streptomyces clavuligerus during industrial fermentations	Andrea Del Rio: Ecology-inspired approaches to identify elicitors and activate silent BGCs
17:15	Poster Session 2 Even Numbers The Ritz

Wednesday 18th June 2025

TIME	SCHEDULE
08:45	Plenary 5 - Mohammad R. Seyedsayamdost Inducing Natural Product Biosynthesis in Streptomyces with Low-Dose Antibiotics Zuiderduinzaal Chair: Justin Nodwell
09:50	Session 9 *Regulatory Networks in Actinobacteria* Zuiderduinzaal Chairs Gilles van Wezel Sébastien Rigali	Session 10 *Ecology of Actinomycetes* Abdijzaal Chairs Geertje van Keulen Daniel Rozen
09:50	Dawn Bignell: Understanding the regulatory networks controlling plant pathogenicity in scab-causing Streptomyces species	Linda Kinkel: The ecological and evolutionary sensitivity of Streptomyces antagonistic phenotypes to habitat nutrient status
10:20	Lixin Zhang: Orchestrating secondary metabolite production in Streptomyces	Shumpei Asamizu: A redox-active compound, catabolically generated through bacterial cross-talk, induces hyphal branching in Streptomyces species
10:50	Coffee Break Lounge area 2
11:15	Chaoxian Bai: CRISPR/dCas9-Powered Genetic Engineering in Streptomyces: A Versatile Platform for Gene Regulation and Antibiotic Discovery	Elijah Bring Horvath: Exploring Actinomycetota Diversity and Biosynthetic Potential in Great Salt Lake
11:35	Kelley Gallagher: Functional evolution of a c-di-GMP-controlled sigma factor	Pauline Gascht: Conjugation mediates large-scale chromosomal transfer in Streptomyces
11:55	Sacha Pidot: Linking genes to secondary metabolites through transposon mutagenesis in human pathogenic Nocardia	Takuto Kumano: Sesamin-metabolizing actinobacteria in nature and larval gut
12:15	Lunch Lounge area 2
13:15	Free Afternoon
13:30	A3 Foresight Network Satellite Meeting Abdijzaal
17:30	ISBA Advisory Board Meeting Chairs Meeting Room Chair: Justin Nodwell
19:00	Feast and NO Famine BBQ Dinner Nautilus

Thursday 19th June 2025

TIME	SCHEDULE
08:45	Plenary 6 - Jos Raaijmakers Harnessing Actinomycetes for Plant Stress Resilience Zuiderduinzaal Chair: Kenji Ueda
09:50	Session 11 *Systems Biology* Zuiderduinzaal Chairs Nigel Mouncey Lorena Fernández Martínez	Session 12 *New Developments in Actinobacterial Biology* Abdijzaal Chairs Justin Nodwell Marie Elliot
09:50	Hannah Augustijn: Genome-wide profiling and conservation of transcriptional regulatory networks in Actinobacteria using DAP-seq	Natalia Tschowri: Second Messenger Functions at the Cell-Environment Interface
10:20	Byung Tae Lee: Pan-reactome analysis of Streptomyces strains reveals association and disconnection between primary and secondary metabolism	Julia Frunzke: Actinobacterial anti-viral strategies
10:35	Linquan Bai: Physiological effects of natural product biosynthesis on its producers
10:50	Coffee Break Lounge area 2
11:15	Natalia M. Vior: Using paired transcriptomics-metabolomics for specialised metabolism mapping in Streptomyces scabies	Hang Wu: diNAD, a new platform to exploit interactive mechanism between cellular NAD and metabolisms in actinomycetes
11:35	Joshua Blodgett: Uncommon insights from common pathways: using polycyclic tetramate macrolactams to understand antibiotic regulatory, evolutionary and biosynthetic complexity	Marc G. Chevrette: Microbial Interactions to Unlock Cryptic Antibiotics
11:55	Varun Sridhar: The oscillation of a quorum sensing system controls antibiotic production in growing Streptomyces coelicolor colonies	Luis Alfredo Avitia-Dominguez: Experimental evolution of multicellularity in Streptomyces venezuelae
12:15	Coffee Break Lounge area 2
12:30	Plenary 7 - Justin Nodwell Chitin catabolism on planet earth Zuiderduinzaal Chair: Gilles van Wezel
13:30	Awards Ceremony: Prizes sponsored by KeAi Publishes Closing remarks Zuiderduinzaal

Programme

Programme overview