Stan van Boeckel
Professor emeritus
- Name
- Prof. dr. C.A.A. van Boeckel
- c.a.a.van.boeckel@chem.leidenuniv.nl
- ORCID iD
- 0000-0002-1576-9598
Professor emeritus
- Faculty of Science
- LIC
- Chemistry for Human Health
- Bio-organic Synthesis
- Bakker A.T., Kotsogianni I., Avalos Garcia M., Punt J.M., Liu B., Piermarini D., Gagestein B., Slingerland C.J., Zhang L., Willemse J.J., Ghimire L.B., Berg Richard J.H.B.N. van den, Janssen A.P.A., Ottenhoff T.H.M., Boeckel C.A.A. van, Wezel G.P. van, Ghilarov D., Martin N.I. & Stelt M. van der (2024), Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria, Nature Chemistry 16: 1462-1472.
- Thaler M., Ofman T.P., Kok K., Heming J.J.A., Moran E., Pickles I., Leijs A.A., Nieuwendijk A.M.C.H. van den, Berg R.J.B.H.N. van den, Ruijgrok G., Armstrong Z.W.B., Salgado-Benvindo C., Ninaber D.K., Snijder E.J., Boeckel C.A.A. van, Artola Perez de Azanza M.E., Davies G.J., Overkleeft H.S. & Hemert M.J. van (2024), Epi-Cyclophellitol cyclosulfate, a mechanism-based endoplasmic reticulum α-Glucosidase II inhibitor, blocks replication of SARS-CoV-2 and other coronaviruses, ACS Central Science 10(8): 1594-1608.
- Jiang M., Huizenga M.C.W., Mohr F.D., Amedi A., Bakker R., Berg R.J.B.H.N. van den, Deng H., Wel T. van der, Boeckel C.A.A. van & Stelt M. van der (2024), Structure-activity relationship studies of aryl sulfoxides as reversible monoacylglycerol lipase inhibitors, Journal of Medicinal Chemistry 67(14): 12331-12348.
- Jiang M., Huizenga M.C.W., Wirth J.L., Paloczi J., Amedi A., Berg R.J.B.H.N. van den, Benz J., Collin L., Deng H., Di X., Driver W.F., Florea B.I., Grether U., Janssen A.P.A., Hankemeier T., Heitman L.H., Lam T.W., Mohr F., Pavlovic A., Ruf I., Hurk H. van den, Stevens A.F., Vliet D. van der, Wel T. van der, Wittwer M.B., Boeckel C.A.A. van, Pacher P., Hohmann A.G. & Stelt M. van der (2023), A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence, Nature Communications 14(1): 8039.
- Jiang M., Huizenga M.C.W., Wirt J.L., Paloczi J., Amedi A., Berg R.J.B.H.N. van den, Benz J., Collin L., Deng H., Di X., Driever W.P.F., Florea B.I., Grether U., Janssen A.P.A., Hankemeier T., Heitman L.H., Lam T.-W., Mohr F.D., Pavlovic A., Ruf I., Hurk H. van den, Stevens A.F., Vliet D. van der, Wel T. van der, Wittwer M.B. Boeckel C.A.A. van, Pacher P., Hohmann A.G. & Stelt M. van der (2023), A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence, Nature Communications 14(1): 8039.
- Mock E.D., Kotsogianni I., Driever W.P.F., Fonseca C.S., Vooijs J.M., Dulk H. den, Boeckel C.A.A. van & Stelt M. van der (2021), Structure–activity relationship studies of pyrimidine-4-carboxamides as inhibitors of N-acylphosphatidylethanolamine phospholipase D, Journal of Medicinal Chemistry 64(1): 481-515.
- Jones P.S., Boucharens S., McElroy S.P., Morrison A., Honarnejad S., Boeckel S. van, Hurk H. van den, Basting D., Hüser J., Jaroch S., Ottow E., Benningshof J., Folmer R.H.A., Leemhuis F., Kramer-Verhulst P.M., Nies V.J.M., Orrling K.M., Rijnders T., Pfander C., Engkvist O., Pairaudeau G., Simpson P.B., Ortholand J.Y., Roche D., Dömling A., Kühnert S.M., Roevens P.W.M., Vlijmen H. van, Wanrooij E.J.A. van, Verbruggen C., Nussbaumer P., Ovaa H., Stelt M. van der, Simonsen K.B., Tagmose L., Waldmann H., Duffy J., Finsinger D., Jurzak M., Burgess-Brown N.A., Lee W.H., Rutjes F.P.J.T., Haag H., Kallus C., Mors H., Dorval T., Lesur B., Ramon Olayo F., Hamza D., Jones G., Pearce C., Piechot A., Tzalis D., Clausen M.H., Davis J., Derouane D., Vermeiren C., Kaiser M., Stockman R.A., Barrault D.V., Swedlow J.R., Nelson A.S., Orru R.V.A., Ruijter E., Helden S.P. van, Li V.M., Vries T. & Vlieger J.S.B. de (2021), IMI European Lead Factory : democratizing access to high-throughput screening, Nature Reviews Drug Discovery 20(2): 85-90.
- Mock E.D., Mustafa M., Gunduz-Cinar O., Cinar R., Petrie G.N., Kantae V., Di X., Ogasawara D., Varga Z.V., Paloczi J., Miliano C., Donvito G., Esbroeck A.C.M. van, Gracht A.M.F. van der, Kotsogianni I., Park J.K., Martella A., Wel T. van der, Soethoudt M., Jiang M., Wendel T.J., Janssen A.P.A., Bakker A.T., Donovan C.M., Castillo L.I., Florea B.I., Wat J., Hurk H. van den, Wittwer M., Grether U., Holmes A., Boeckel C.A.A. van, Hankemeier T., Cravatt B.F., Buczynski M.W., Hill M.N., Pacher P., Lichtman A.H. & Stelt M. van der (2020), Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice, Nature Chemical Biology 16(6): 667-675.
- Mons E., Jansen I.D.C., Loboda J., Doodewaerd B.R. van, Hermans J., Verdoes M., Boeckel C.A.A. van, Veelen P.A. van, Turk B., Turk D. & Ovaa H. (2019), The alkyne moiety as a latent electrophile in irreversible covalent small molecule inhibitors of Cathepsin K, Journal of the American Chemical Society 141(8): 3507-3514.
- Janssen A.P.A., Grimm S.H., Wijdeven R.H.M., Lenselink E.B., Neefjes J.J.C., Boeckel C.A.A. van, Westen G.J.P. van & Stelt M. van der (2019), Drug Discovery Maps, a Machine Learning Model That Visualizes and Predicts Kinome-Inhibitor Interaction Landscapes, Journal of Chemical Information and Modeling 59(3): 1221-1229.
- Ghisaidoobe Amar T., Van den Berg Richard J.B.H.N., Butt Saleem S., Strijland Anneke, Donker-Koopman Wilma E., Scheij Saskia, Van den Nieuwendijk Adrianus M.C.H., Koomen Gerrit-Jan, Van Loevezijn Arnold, Leemhuis Mark, Wennekes Tom, Van der Stelt Mario, Van der Marel Gijsbert A., Van Boeckel Constant A.A., Aerts Johannes M.F.G. & Overkleeft Herman S. (2014), Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors, Journal of Medicinal Chemistry 57(21): 9096-9104.
- Codee J.D.C., Stubba B., Schiattarella M., Overkleeft H.S., Boeckel C.A.A. van, Boom J.H. van & Marel G.A. van der (2005), A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy, Journal of the American Chemical Society 127(11): 3767-3773.
- Codée J.D.C., Stuba B., Schiatterella M., Overkleeft H.S., Boeckel C.A.A. van, Boom J.H. van & Marel G.A. van der (2005), A modular strategy towards the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy, Journal of the American Chemical Society 127: 3767-3773.
- Codee J.D.C., Bos L.J. van den, Litjens R.E.J.N., Overkleeft H.S., Boeckel C.A.A. van, Boom J.H. van & Marel G.A. van der (2004), Chemoselective glycosylations using sulfonium triflate activator systems, Tetrahedron 60(5): 1057-1064.
- Codée J.D., Overkleeft H.S., Marel G.A. van der & Boeckel C.A. van (2004), The synthesis of well-defined heparin and heparan sulfate fragments, Drug Discovery Today: Technologies 1(3): 317-26.
- Verhelst S.H.L., Wiedenhof W., Ovaa H., Marel G.A. van der, Overkleeft H.S., Boeckel C.A.A. van & Boom J.H. van (2002), A stereoselective route towards highly functionalized 4,6-diaminocyclohexene derivatives, Tetrahedron Letters 43: 6451-6455.
- Codee J.D.C., Marel G.A. van der, Boeckel C.A.A. van & Boom J.H. van (2002), Probing the heparin - Antithrombin III interaction using synthetic pentasaccharides bearing positively charged groups, European Journal of Organic Chemistry 23: 3954-3965.
- Hooft P.A.V. van, Marel G.A. van der, Boeckel C.A.A. van & Boom J.H. van (2001), Triisobutylaluminium mediated carbocyclisation of sugar derived spiroketals and ketosides, Tetrahedron Letters 42: 1769-1722.
- Hooft P.A.V. van, Swieten P.F. van, Marel G.A. van der, Boeckel C.A.A. van & Boom J.H. van (2001), Montmorillonite K-10 clay assisted transformation of vinylketoses into spirochromans and arylketoses, SYNLETT (2): 269-271.
- Hooft P.A.V. van, Litjens R.E.J.N., Marel G.A. van der, Boeckel C.A.A. van & Boom J.H. van (2001), Stereoselective transformations on D-glucose-derived eight-membered ring carbocycles, Organical Letters 3: 731-733.
- Buijsman R.C., Basten J.E.M., Dreef-Tromp C.M., Marel G.A. van der, Boeckel C.A.A. van & Boom J.H. van (1999), Synthesis of heparin-like antithrombotics having perphosphorylated thrombin binding domains, 7: 1881.
- Buijsman R.C., Basten J.E.M., Van Dinther J.G., Marel G.A. van der, Boeckel C.A.A. van & Boom J.H. van (1999), Design and synthesis of a novel synthetic NAPAP-pentasaccharide conjugate displaying a dual antithrombotic action, 9: 2013.
- Marel G.A. van der, Heskamp B.M., Boeckel C.A.A. van, Veeneman G.H. & Boom J.H. van (1998), Design and synthesis of potential fucosyl transferase inhibitors. In: Chapleur Y. (Ed.), Carbohydrate Mimics Concepts and Methods. Weinheim: Wiley-VCH. 491-510.
- Hooft P.A.V. van, Leeuwenburgh M.A., Overkleeft H.S., Marel G.A. van der, Boeckel C.A.A. van & Boom J.H. van (1998), A novel and flexible synthesis of pyranose spiroacetal derivatives, Tetrahedron Letters 39: 6061-6064.