Research project
(Functional) genomics of DNA-damage stress responses
todo
- Contact
- Bob van de Water
We make use of microarray analysis to examine the transcriptional changes associated with stress responses and aging disorders. With this approach, we can identify sentinel proteins that can serve as reporters for high-throughput hazard assesment of toxic chemicals. In addition to high throughput screening, we also use a functional genomic approach to perform detailed analyses of stress signalling pathways in embryonic stem cells.
Related research
-
(Functional) genomics of DNA-damage stress responses
- Genomic analysis of DNA-damage stress responses and aging disorders
- Mechanism-based toxicogenomics to develop an in vitro high throughput reporter models for human cancer hazard assessment of (non)-genotoxic chemicals
- Systematic analysis of signaling pathways that control the DNA-damage response in embryonic stem (ES) cells