Molecular Physiology is a research group at the Leiden Institute of Chemistry, headed by Dr. Mario van der Stelt. The research aim is to design, synthesize and apply new chemical tools to answer important biological and medical questions. We use activity-based protein profiling, assay development, chemical proteomics and advanced molecular biology techniques to determine the activity and selectivity of small molecules in physiological and disease processes. We have a focus on cancer, metabolic and brain disorders.
In a multidisciplinary research line, we combine organic and medicinal chemistry with molecular biology and chemical biology. We use computational chemistry together with activity-based probes for compound profiling and optimization. In (inter)national collaborations with biologists and pharmacologists we test our molecules in preclinical models of disease. Our current projects focus on kinases and proteins of the endocannabinoid system.