Mireia Bernabé Kleijn
Lab manager
- Name
- M.N.A. Bernabé Kleijn BSc
- Telephone
- 071 5276051
- m.n.a.bernabe.kleijn@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0001-6027-6154
Lab manager
- Faculty of Science
- LACDR
- Divisie Biotherapeutics
- Delfos L., Depuydt M.A.C., Chemaly M., Coyle S., Schaftenaar F.H., Santbrink P.J. van, Lindenbergh P.P., Bernabé Kleijn M.N.A., Costello C., Power C.A., Coll R., Peace A., Gregory-Ksander M., Foks A.C., Kuiper J., McGilligan V., Bot I. & (2025), NLRP3 inflammasome inhibition by the novel bispecific antibody InflamAb attenuates atherosclerosis in apolipoprotein e–deficient mice, JACC: Basic to Translational Science 10(6): 826-840.
- Mol J. de, Smit V., Barnabé Kleijn M.N.A., Santbrink P.J. van, Bot I. & Foks A.C. (2025), Immunosenescence accelerates atherosclerosis development in AAV-PCSK9 mouse model, GeroScience 47: 6549-6563.
- Lozano Vigario F., Molenaar J., Simó Vesperinas I., Zon M. van der, Crone N.S.A.., Jong M.J.M. de, Hemme E., Depuydt M.A.C., Delfos L., Mol J. de, Bernabé Kleijn M.N.A., Peeters J.A.H.M., Wezel A., Smeets H.J., Tjokrodirijo R.T.N., Ru A.H. de, Kros A., Quax P.H.A., Vries M.R. de, Kuiper J., Bot I., Veelen P. van & Slütter B.A. (2025), Immunopeptidomics analysis of human atherosclerosis plaques identifies antigenic drivers of atherosclerosis, Atherosclerosis 409: 120509.
- Schaftenaar F.H., Dam A.D. van, Bruin G. de, Depuydt M.A.C., Mol J., Amersfoort J., Douna H., Meijer M., Kröner M.J., Santbrink P.J. van, Bernabé Kleijn M.N.A., Puijvelde G.H.M. van, Florea B.I., Slütter B., Foks A.C., Bot I., Rensen P.C.N. & Kuiper J. (2024), Immunoproteasomal inhibition with ONX-0914 attenuates atherosclerosis and reduces white adipose tissue mass and metabolic syndrome in mice, Arteriosclerosis, Thrombosis, and Vascular Biology 44(6): 1346–1364.
- Smit V., Mol J. de, Bernabé Kleijn M.N.A.B., Depuydt M.A.C., Winther M.P.J. de Bot I., Kuiper J. & Foks A.C. (2024), Sexual dimorphism in atherosclerotic plaques of aged Ldlr-/- mice, Immunity and Ageing 21(1): 27.
- Hoekstra M., Snip O.S.C., Janusz P., Bernabé Kleijn M.N.A., Truitt E.R., Sullivan B.D., Schmidt T.A., Jay G.D. & Eck M. van (2024), Recombinant human proteoglycan 4 lowers inflammation and atherosclerosis susceptibility in female low-density lipoprotein receptor knockout mice, Journal of Physiology London 602(9): 1939-1951.
- Bot I., Delfos L., Hemme E., Bernabé Kleijn M.N.A., Santbrink P.J. van, Foks A.C., Kovanen P.T., Jouppila A. & Lassila R. (2024), Treatment with APAC, a dual antiplatelet anticoagulant heparin proteoglycan mimetic, limits early collar-induced carotid atherosclerotic plaque development in Apoe-/- mice, Atherosclerosis 397: 118567.
- Smit V., Mol J. de, Schaftenaar F.H., Depuydt M.A.C., Postel R.J., Smeets D.: Verheijen F.W.M., Bogers L., Duijn J. van, Verwilligen R.A.F., Grievink H.W., Bernabé Kleijn M.N.A., Ingen E. van, Jong M.J.M. de, Goncalves L.: Peeters J.A.H.M., Smeets H.J., Wezel A., Polansky J.K., Winther M.P.J. de, Binder C.J., Tsiantoulas D., Bot I., Kuiper J. & Foks A.C. (2023), Single-cell profiling reveals age-associated immunity in atherosclerosis, Cardiovascular Research 119(15): 2508-2521.
- Delfos L., Depuydt M.A.C., Foks A.C., Bernabe Kleijn M.N.A., Kuiper J., Chemaly M., Peace A., McGilligan V. & Bot I. (2023), NLRP3 inflammasome inhibition by the novel bispecific antibody inflamab inhibits atherosclerosis in apolipoprotein E-deficient mice, Atherosclerosis 379(Supplement 1): S2.
- Depuydt M.A.C., Schaftenaar F.H., Prange H.H.M., Boltjes A., Hemme E., Delfos L., Mol J. de, Jong M.J.M. de, Bernabé Kleijn M.N.A., Peeters J.A.H.M., Goncalves L., Wezel A., Smeets H.J., Borst G.J. de, Foks A.C., Pasterkamp G., Winther M.P.J. de, Kuiper J., Bot I. & Slütter B. (2023), Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells, Nature Cardiovascular Research 2: 112-125.
- Hemme E.: Biskop D., Depuydt M.A.C., Smit V., Delfos L., Bernabé Kleijn M.N.A., Foks A.C., Kuiper J. & Bot I. (2023), Bruton's Tyrosine Kinase inhibition by Acalabrutinib does not affect early or advanced atherosclerotic plaque size and morphology in Ldlr-/- mice, Vascular Pharmacology 150: 107172.
- Mol J. de, Postel R.J., Smit V., Bernabé Kleijn M.N.A., Bot I., Kuiper J. & Foks A.C. (2022), B cell depletion skews cd4+t cell towards a pro-inflammatory phenotype in aged atherosclerotic mice, Cardiovascular Research 118(Supplement_1): cvac066.230.
- Hemme E., Delfos L., Depuydt M.A.C., Bernabé Kleijn M.N.A., Schaftenaar F.H., Foks A.C., Kuiper J. & Bot I. (2022), Brutons tyrosine kinase inhibition to suppress mast cell activation in atherosclerosis, Cardiovascular Research 118(Supplement_1): cvac066.227.
- Depuydt M.A.C., Smit V., Lozano Vigario F., Bernabé Kleijn M.N.A., Vries M.R. de, Quax P.H.A., Wezel A., Smeets H.J., Kuiper J., Foks A.C., Bot I. & Slütter B.A. (2022), Granzyme B+CD4+T cells associate with an unstable plaque phenotype in advanced human atherosclerosis, Cardiovascular Research 118(Supplement_1): cvac066.229.
- Depuydt M.A.C., Vlaswinkel F.D., Hemme E., Delfos L., Bernabe Kleijn M.N.A., Santbrink P.J. van, Foks A.C., Slütter B., Kuiper J. & Bot I. (2022), Blockade of the BLT1-LTB4 axis does not affect mast cell migration towards advanced atherosclerotic lesions in LDLr-/- mice, Scientific Reports 12(1): 18362.
- Postel R.J., Smit V., De Mol J., Bernabé Kleijn M.N.A., De Jong M.J.M., Delfos L., Hemme E., Depuydt M.A.C., Bot I., Kuiper J. & Foks A.C. (2022), IL-21R blockade reduces atherosclerosis development in LDLR-/- mice, Atherosclerosis 355: 23.
- Douna H., Amersfoort J., Schaftenaar F.H., Kröner M.J., Kiss M.B., Slütter B.A., Depuydt M.A.C., Bernabé Kleijn M.N.A., Wezel A., Smeets H., Yagita H., Binder C.J., Bot I., Puijvelde G.H.M. van, Kuiper J. & Foks A.C. (2020), BTLA stimulation protects against atherosclerosis by regulating follicular B cells, Cardiovascular Research 116(2): 295-305.
- Douna H., Amersfoort J., Schaftenaar F.H., Kröner M.J., Kiss M.B., Slütter B., Depuydt M.A.C., Kleijn M.N.A.B., Wezel A., Smeets H., Yagita H., Binder C.J., Bot I., Puijvelde G.H.M. van, Kuiper J. & Foks A.C. (2019), B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells, Cardiovascular Research 116(2): 295-305.