Meindert Lamers
Professor of Structural Biology & Director of NeCEN
- Name
- Prof. dr. M.H. Lamers
- Telephone
- 071 5271413
- m.h.lamers@lumc.nl
- ORCID iD
- null
Meindert H. Lamers is co-director of the Netherlands Center for Electron Nanoscopy (NeCEN) at the Faculty of Science and head of the section Light and Electron Microscopy at the Leiden University Medical Center (LUMC). His research group at the LUMC studies molecular mechanisms of DNA replication and DNA repair.
More information
For details on Meindert Lamers' research, please visit the webpage of Lamer's lab.
Professor of Structural Biology & Director of NeCEN
- Faculty of Science
- IBL
- NeCEN
Contact
Professor
- Faculty of Medicine
- LUMC
Contact
- Ren M.R., Li D., Addison H., Noteborn W.E.M., Andeweg E.H., Glatter T., Winde J.H. de, Rebelein J.G., Lamers M.H. & Schada von Borzyskowski L. (2025), NAD-dependent dehydrogenases enable efficient growth of Paracoccus denitrificans on the PET monomer ethylene glycol, Nature Communications 16: 5845.
- Kuin R.C.M., Lamers M.H. & Westen G.J.P. van (2025), PyVADesign: a python-based cloning tool for one-step generation of large mutant libraries, Bioinformatics 41(9): btaf433.
- Kuin R.C.M., Westen G.J.P. van & Lamers M.H. (2025), Identification of determinants of high-fidelity DNA synthesis in mycobacterium smegmatis DnaE1 through in silico and in vivo approaches, Nucleic Acids Research 53(21): gkaf1274.
- Santos, J.A.; Timinskas, K.; Ramudzuli, A.A.; Lamers, M.H.; Venclovas, C.; Warner, D.F. & Gessner, S.J. (2025), The RecA-NT homology motif in ImuB mediates the interaction with ImuA0, which is essential for DNA damage-induced mutagenesis, Journal of Biological Chemistry 301(2).
- Fernow, J.; Olliver, M.; Couet, W.; Lagrange, S.; Lamers, M.H.; Olesen, O.F.; Orrling, K.; Pieren, M.; Sloan, D.J.; Vaquero, J.J.; Miles, T.J. & Karlen, A. (2025), The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships, Nature Reviews Drug Discovery 24(1): 1-2.
- Xu, L.F.; Jin, S.K.; Urem, M.; Lee, S.J.; Lamers, M.H.; Chen, X.; Wolynes, P.G. & Wuite, G.J.L. (2025), DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins, Nature Communications 16(1).
- Fountain, A.J.; Böhning, J.; McLaughlin, S.H.; Morgan, T.E.; Edelstein, P.H.; Troll, M.; Lamers, M.H.; Bharat, T.A.M.; Luisi, B. & Ramakrishnan, L. (2025), Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance, Proceedings of the National Academy of Sciences 122(39).
- Kuin, R.C.M.; Lamers, M.H. & Westen, G.J.P. van (2025), PyVADesign: a python-based cloning tool for one-step generation of large mutant libraries, Bioinformatics 41(9).
- Ren, M.R.; Li, D.N.; Addison, H.; Noteborn, W.E.M.; Andeweg, E.H.; Glatter, T.; Winde, J.H. de; Rebelein, J.G.; Lamers, M.H. & Borzyskowski, L.S. von (2025), NAD-dependent dehydrogenases enable efficient growth of Paracoccus denitrificans on the PET monomer ethylene glycol, Nature Communications 16(1).
- Kuin, R.C.M.; Westen, G.J.P. van & Lamers, M.H. (2025), Identification of determinants of high-fidelity DNA synthesis in Mycobacterium smegmatis DnaE1 through in silico and in vivo approaches, Nucleic Acids Research 53(21).
- Urem, M.; Friggen, A.H.; Musch, N.; Silverman, M.H.; Swain, C.J.; Barbachyn, M.R.; Mortin, L.I.; Yu, X.; Deluccia, R.J.; Lamers, M.H. & Smits, W.K. (2025), A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens, Nature Communications 16(1).
- Lippai, Z.; Péterfia, B.; Papp, G.; Dezso, K.; Bedics, G.; Pápai, Z.; Lamers, M.H.; Kuin, R.C.M.; Szuhai, K. & Sápi, Z. (2024), A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas, European Journal of Cancer 202.
- Kemps, P.G.; Baelde, H.J.; Vorderman, R.H.P.; Stelloo, E.; Swennenhuis, J.F.; Szuhai, K.; Lamers, M.H.; Kenkhuis, B.; Al-Hussaini, M.; Briaire-de Bruijn, I.H.; Lam, S.W.; Bovée, J.V.M.G.; Cleven, A.H.G.; Verdijk, R.M.; Noesel, C.J.M.; Dijk, M.R.; Scheijde-Vermeulen, M.A.; Bruggink, A.H.; Laar, J.A.M.; Vries, A.C.H.; Tissing, W.J.E.; Bos, C. van den; Deimling, A. von; Wezel, T. van; Halteren, A.G.S. & Hogendoorn, P.C.W. (2024), Recurrent CLTC::SYK fusions and CSF1R mutations in juvenile xanthogranuloma of soft tissue, Blood 144(23): 2439-2455.
- Gessner, S.; Martin, Z.A.M.; Reiche, M.A.; Santos, J.A.; Dinkele, R.; Ramudzuli, A.; Dhar, N.; Wet, T.J. de; Anoosheh, S.; Lang, D.M.; Aaron, J.; Chew, T.L.; Herrmann, J.; Müller, R.; McKinney, J.D.; Woodgate, R.; Mizrahi, V.; Venclovas, C.; Lamers, M.H. & Warner, D.F. (2023), Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome, eLife 12.
- Botto, M.M.; Borsellini, A. & Lamers, M.H. (2023), A four-point molecular handover during Okazaki maturation, Nature Structural and Molecular Biology 30(10): 1505-+.
- Botto, M.M.; Murthy, S. & Lamers, M.H. (2023), High-throughput exonuclease assay based on the fluorescent base Analogue 2-aminopurine, ACS Omega 8(9).
- Chengalroyen, M.D.; Mason, M.K.; Borsellini, A.; Tassoni, R.; Abrahams, G.L.; Lynch, S.; Ahn, Y.M.; Ambler, J.; Young, K.; Crowley, B.M.; Olsen, D.B.; Warner, D.F.; Barry, C.E.; Boshoff, H.I.M.; Lamers, M.H. & Mizrahi, V. (2022), DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis, ACS Infectious Diseases 8(3): 612-625.
- Borsellini, A.; Kunetsky, V.; Friedhoff, P. & Lamers, M.H. (2022), Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair, Nature Structural and Molecular Biology 29(1): 59-+.
- Borsellini, A.; Lebbink, J.H.G. & Lamers, M.H. (2022), MutL binds to 3 ' resected DNA ends and blocks DNA polymerase access, Nucleic Acids Research 50(11): 6224-6234.
- Xiao, X.S.; Willemse, J.; Voskamp, P.; Li, X.M.; Prota, A.E.; Lamers, M.; Pannu, N.; Abrahams, J.P. & Wezel, G.P. van (2021), Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces, Open Biology 11(2).
- Fernandez-Leiro, R.; Bhairosing-Kok, D.; Kunetsky, V.; Laffeber, C.; Winterwerp, H.H.; Groothuizen, F.; Fish, A.; Lebbink, J.H.G.; Friedhoff, P.; Sixma, T.K. & Lamers, M.H. (2021), The selection process of licensing a DNA mismatch for repair, Nature Structural and Molecular Biology 28(4): 373-+.
- Singh, J.K.; Smith, R.; Rother, M.B.; Groot, A.J.L. de; Wiegant, W.W.; Vreeken, K.; D'Augustin, O.; Kim, R.Q.; Qian, H.B.; Krawczyk, P.M.; Gonzalez-Prieto, R.; Vertegaal, A.C.O.; Lamers, M.; Huet, S. & Attikum, H. van (2021), Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining, Nature Communications 12(1).
- Dodd, T.; Botto, M.; Paul, F.; Fernandez-Leiro, R.; Lamers, M.H. & Ivanov, I. (2020), Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path, Nature Communications 11(1).
- Santos, J.A. & Lamers, M.H. (2020), Novel antibiotics targeting bacterial replicative DNA polymerases, Antibiotics 9(11).
- Lemmers, R.J.L.F.; Stoep, N. van der; Vliet, P.J. van der; Moore, S.A.; Granado, D.S.; Johnson, K.; Topf, A.; Straub, V.; Evangelista, T.; Mozaffar, T.; Kimonis, V.; Shaw, N.D.; Selvatici, R.; Ferlini, A.; Voermans, N.; Engelen, B. van; Sacconi, S.; Tawil, R.; Lamers, M. & Maarel, S.M. van der (2019), SMCHD1 mutation spectrum for facioscapulohumeral muscular dystrophy type 2 (FSHD2) and Bosma arhinia microphthalmia syndrome (BAMS) reveals disease-specific localisation of variants in the ATPase domain, Journal of Medical Genetics 56(10): 693-700.
- Gahlon, H.L.; Walker, A.R.; Cisneros, G.A.; Lamers, M.H. & Rueda, D.S. (2018), Reduced structural flexibility for an exonuclease deficient DNA polymerase III mutant, Physical Chemistry Chemical Physics 20(42): 26892-26902.
- Lamers, M.; Berlin, I. & Neefjes, J. (2018), Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck, Current Biology 28(2): R83-R86.
- Gahlon, H.L.; Zhao, G.; Fernandez-Leiro, R.; Lamers, M.H. & Rueda, D. (2017), Dynamic proofreading in bacterial DNA polymerase III, European Biophysics Journal with Biophysics Letters 46: S142-S142.
- Zhao, G.J.; Gleave, E.S. & Lamers, M.H. (2017), Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis, eLife 6.
- Fernandez-Leiro, R.; Conrad, J.; Yang, J.C.; Freund, S.M.V.; Scheres, S.H.W. & Lamers, M.H. (2017), Self-correcting mismatches during high-fidelity DNA replication, Nature Structural & Molecular Biology 24(2): 140-+.
- Banos-Mateos, S.; Roon, A.M.M. van; Lang, U.F.; Maslen, S.L.; Skehel, J.M. & Lamers, M.H. (2017), High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center, Nature Communications 8.
- Aibara, S.; Valkov, E.; Lamers, M.H.; Dimitrova, L.; Hurt, E. & Stewart, M. (2015), Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum, Acta Crystallographica Section F: Structural Biology Communications 71: 876-888.
- Fernandez-Leiro, R.; Conrad, J.; Scheres, S.H.W. & Lamers, M.H. (2015), cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and tau, eLife 4.
- Aibara, S.; Valkov, E.; Lamers, M. & Stewart, M. (2015), Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface, Nucleic Acids Research 43(3): 1927-1936.
- Rock, J.M.; Lang, U.F.; Chase, M.R.; Ford, C.B.; Gerrick, E.R.; Gawande, R.; Coscolla, M.; Gagneux, S.; Fortune, S.M. & Lamers, M.H. (2015), DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader, Nature Genetics 47(6): 677-681.
- Vidangos, N.K.; Heideker, J.; Lyubimov, A.; Lamers, M.; Huo, Y.X.; Pelton, J.G.; Ton, J.; Gralla, J.; Berger, J. & Wemmer, D.E. (2014), DNA Recognition by a sigma(54) Transcriptional Activator from Aquifex aeolicus, Journal of Molecular Biology 426(21): 3553-3568.
- Barros, T.; Guenther, J.; Kelch, B.; Anaya, J.; Prabhakar, A.; O'Donnell, M.; Kuriyan, J. & Lamers, M.H. (2013), A structural role for the PHP domain in E. coli DNA polymerase III, {BMC} Structural Biology 13.
- Rego, A.T.; Holding, A.N.; Kent, H. & Lamers, M.H. (2013), Architecture of the Pol III-clamp-exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair, The EMBO Journal 32(9): 1334-1343.
- Holding, A.N.; Lamers, M.H.; Stephens, E. & Skehel, J.M. (2013), Hekate: Software Suite for the Mass Spectrometric Analysis and Three-Dimensional Visualization of Cross-Linked Protein Samples, Journal of Proteome Research 12(12): 5923-5933.
- Hadders, M.A.; Agromayor, M.; Obita, T.; Perisic, O.; Caballe, A.; Kloc, M.; Lamers, M.H.; Williams, R.L. & Martin-Serrano, J. (2012), ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes, Proceedings of the National Academy of Sciences 109(43): 17424-17429.
- Jura, N.; Endres, N.F.; Engel, K.; Deindl, S.; , R. das; Lamers, M.H.; Wemmer, D.E.; Zhang, X.W. & Kuriyan, J. (2009), Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment, Cell 137(7): 1293-1307.
- Winger, J.A.; Derbyshire, E.R.; Lamers, M.H.; Marletta, M.A. & Kuriyan, J. (2008), The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase, {BMC} Structural Biology 8.
- Batchelor, J.D.; Doucleff, M.; Lee, C.J.; Matsubara, K.; Carlo, S. de; Heideker, J.; Lamers, M.H.; Pelton, J.G. & Wemmer, D.E. (2008), Structure and Regulatory Mechanism of Aquifex aeolicus NtrC4: Variability and Evolution in Bacterial Transcriptional Regulation, Journal of Molecular Biology 384(5): 1058-1075.
- Lamers, M.H. & O'Donnell, M. (2008), A consensus view of DNA binding by the C family of replicative DNA polymerases, Proceedings of the National Academy of Sciences 105(52): 20565-20566.
- Lamers, M.H.; Georgescu, R.E.; Lee, S.G.; O'Donnell, M. & Kuriyan, J. (2006), Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III, Cell 126(5): 881-892.
- Lamers, M.H.; Gerogijevic, D.; Lebbink, J.H.; Winterwerp, H.H.K.; Agianian, B.; Wind, N. de & Sixma, T.K. (2004), ATP increases the affinity between MutS ATPase domains - Implications for atp hydrolysis and conformational changes, Journal of Biological Chemistry 279(42).
- Natrajan, G.; Lamers, M.H.; Enzlin, J.H.; Winterwerp, H.H.K.; Perrakis, A. & Sixma, T.K. (2003), Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates, Nucleic Acids Research 31(16): 4814-4821.
- Lamers, M.H.; Winterwerp, H.H.K. & Sixma, T.K. (2003), The alternating ATPase domains of MutS control DNA mismatch repair, The EMBO Journal 22(3): 746-756.
- Wu, S.Y.; Culligan, K.; Lamers, M. & Hays, J. (2003), Dissimilar mispair-recognition spectra of Arabidopsis DNA-mismatch-repair proteins MSH2.MSH6 (MutS alpha) and MSH2.MSH7 (MutS gamma), Nucleic Acids Research 31(20): 6027-6034.
- Lamers, M.H.; Perrakis, A.; Enzlin, J.H.; Winterwerp, H.H.K.; Wind, N. de & Sixma, T.K. (2000), The crystal structure of DNA mismatch repair protein MutS binding to a G center dot T mismatch, Nature 407(6805).