Lizi Xia
PhD candidate / guest
- Name
- Dr. L. Xia
- Telephone
- +31 71 527 4237
- l.xia.2@lacdr.leidenuniv.nl
Lizi (Lance) Xia is a Ph.D. student at the Division of Medicinal Chemistry. Lance performs kinetic studies on Cannabinoid CB1 receptor, which is a potential target related to weight-control via lowering the concentration of plasma lipids and cholesterol.
In China I was educated and trained as Medicinal chemist. I did my bachelor in pharmaceutical sciences and performed academic and industrial research in both chemistry and biology. In February 2011, I came to Leiden University to study science based business (SBB) and bio-pharmaceutical sciences (BFW). I found the research here is what I like most; therefore, I did a 9-month internship in organic synthesis, under the supervision of Mr. Guo and Dr. J. Brussee. I synthesized about 50 compounds and analyzed them for their Structure-kinetics and Structure-affinity Relationships on the Adenosine A 2A receptor.
Right after that, I did another 6-month internship in biochemistry under the supervision of Mr. Massink, Dr. Heitman and Prof. Dr. IJzerman, based on the latest crystal structure of the Adenosine A 2A receptor; its “Sodium Ion Pocket” was confirmed as a highly conserved allosteric site.
Unfortunately, after two years my Dutch is still poor, but luckily I can continue to do my PhD study in the same group in Leiden. Now with the founding of the “K4DD” consortium and together with partners from both academia and industry, I am allowed to do kinetic studies on Cannabinoid CB 1 receptor, which is a potential target related to weight-control via lowering the concentration of plasma lipids and cholesterol. Next to the affinity and selectivity, the kinetic characteristics of small molecules as ligands for the Cannabinoid CB 1 receptor will be defined via improved methods and technology in a high throughput fashion. In the end, I hope my in vitro discoveries can be translated to in vivo effects from intact cell to whole animal or human body.
PhD candidate / guest
- Faculty of Science
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal chemistry
- Bouma J., Soethoudt M., Gils N. van, Xia L., Stelt M van der & Heitman L.H. (2022), Cellular assay to study β-arrestin recruitment by the cannabinoid receptors 1 and 2. In: Maccarrone M. (Ed.), Endocannabinoid Signaling. Methods in Molecular Biology no. 2576. New York, U.S.A.: Humana. 189-199.
- Xia L. (30 May 2018), Corpora non agunt nisi fixata : ligand receptor binding kinetics in G protein-coupled receptors (Dissertatie. Leiden Academic Centre for Drug Research (LACDR), Science, Leiden University). Supervisor(s) and Co-supervisor(s): IJzerman A.P., Heitman L.H.
- Xia L., Vries H. de, Yang X., Lenselink E.B., Kyrizaki A., Barth F., Louvel J., Dreyer M.K., Es D. van der, IJzerman A.P. & Heitman L.H. (2018), Kinetics of human cannabinoid 1 (CB1) receptor antagonists: Structure-kinetics relationships (SKR) and implications for insurmountable antagonism, Biochemical Pharmacology 151: 166-179.
- Xia L.Z., Kyrizaki A., Tosh D.K., Duijl T.T. van, Roorda J.C., Jacobson K.A., IJzerman A.P. & Heitman L.H. (2018), A binding kinetics study of human adenosine A(3) receptor agonists, Biochemical Pharmacology 153: 248-259.
- Xia L., Vries H. de, Lenselink E.B., Louvel J.A., Waring M.J., Cheng L., Pahlen S., Petersson M.J., Schell P., Olsson R.I., Heitman L.H., Sheppard R.J. & IJzerman A.P. (2017), Structure-Affinity Relationships and Structure-Kinetic Relationships of 1,2-Diarylimidazol-4-carboxamide Derivatives as Human Cannabinoid 1 Receptor Antagonists, Journal of Medicinal Chemistry 60(23): 9545-9564.
- Xia L., Burger W.A.C., Veldhoven J.P.D. van, Kuiper B.J., Duijl T.T. van, Lenselink E.B., Paasman E., Heitman L.H. & IJzerman A.P. (2017), Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A(3) Receptor Antagonists, Journal of Medicinal Chemistry 60(17): 7555-7568.
- Xia L., Vries H. de, IJzerman A.P. & Heitman L.H. (2016), Scintillation proximity assay (SPA) as a new approach to determine a ligand's kinetic profile. A case in point for the adenosine A1 receptor, Purinergic Signalling 12(1): 115-126.
- Massink A., Gutiérrez-de-Terán H., Lenselink E.B., Ortiz Zacarías N.V., Xia L., Heitman L.H., Katritch V., Stevens R.C. & IJzerman A.P. (2015), Sodium Ion Binding Pocket Mutations and Adenosine A2A Receptor Function, Molecular Pharmacology 87(2): 305-13.
- Guo D., Xia L., Veldhoven J.P.D. van, Hazeu M.D., Mocking T., Brussee J.M., IJzerman A.P. & Heitman L.H. (2014), Binding kinetics of ZM241385 derivatives at the human adenosine A(2A) receptor, ChemMedChem 9(4): 752-761.
- Louvel J.A., Guo D., Agliardi M., Mocking T.A.M., Kars R., Xia L., Vries H. de, Brussee J., Heitman L.H. & IJzerman A.P. (2014), Agonists for the adenosine A(1) receptor with tunable residence time: a case for nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines, Journal of Medicinal Chemistry 57(8): 3213-3222.
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