Koen van der Maaden
Guest
- Name
- Dr. K. van der Maaden
- ORCID iD
- 0000-0003-0682-2403
Dr. Koen van der Maaden is a postdoc researcher at the Division of Drug Delivery Technology.
Biography
Koen van der Maaden studied pharmacy at Utrecht University (2004-2008; Bachelor) and bio-pharmaceutical sciences at Leiden University (2008-2010; Master). After obtaining his Master’s degree with honors (cum laude) he enrolled into the PhD program of Leiden University under the supervision of prof dr Joke Bouwstra and prof dr Wim Jiskoot. During his PhD project he focused on microneedle-based intradermal vaccine delivery systems for minimally-invasive and pain-free vaccination. This work resulted in 9 first-author papers and two patent applications. He defended his thesis, entitled “Microneedle-mediated vaccine delivery”, in 2014 and obtained his PhD degree with honors (cum laude). He received the C.J. Kok prize for best dissertation of the year 2015 of the Faculty of Science of Leiden University. After his PhD he worked for one year for MyLife Technologies at IntraVacc on vaccine delivery via nanoporous microneedles. Since 2015 he works 20% at MyLife Technologies and 80% at Leiden University.
Guest
- Faculty of Science
- LACDR
- Divisie Biotherapeutics
- Lee J., Neustrup M.A., Slütter B.A., O'Mahony C., Bouwstra J.A. & Maaden K. van der (2024), Intradermal vaccination with PLGA nanoparticles via dissolving microneedles and classical injection needles, Pharmaceutical Research 41: 305–319.
- Neustrup M.A., Ottenhoff T.H.M., Jiskoot W., Bouwstra J.A. & Maaden K. van der (2024), A versatile, low-cost modular microfluidic system to prepare poly(lactic-co-glycolic acid) nanoparticles with encapsulated protein, Pharmaceutical Research 41: 2347-2361.
- Lee J., Beukema M., Zaplatynska O.A., O'Mahony C., Hinrichs W.L.J., Huckriede A.L.W., Bouwstra J.A. & Maaden K. van der (2023), Efficient fabrication of thermo-stable dissolving microneedle arrays for intradermal delivery of influenza whole inactivated virus vaccine, Biomaterials Science 11(20): 6790-6800.
- Tian Y., Lee J., Maaden K. van der, Bhide Y., Vries-Idema J.J. de, Akkerman R., O'Mahony C., Jiskoot W., Frijlink H.W., Huckriede A.L.W., Hinrichs W.L.J., Bouwstra J.A. & Beukema M. (2022), Intradermal administration of influenza vaccine with trehalose and pullulan-based dissolving microneedle arrays, Journal of Pharmaceutical Sciences 111(4): 1070-1080.
- Jacobse J., Voorde W. ten, Tandon A., Romeijn S.G., Grievink H.W., Maaden K. van der, Esdonk M.J. van, Moes D.J.A.R., Loeff F., Bloem K., Vries A. de, Rispens T., Wolbink G., Kam M. de, Ziagkos D., Moerland M., Jiskoot W., Bouwstra J., Burggraaf J., Schrier L., Rissmann R. & Cate R. ten (2021), Comprehensive evaluation of microneedle-based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial, British Journal of Clinical Pharmacology 87(8): 3162-3176.
- Lee J., Maaden K. van der, Gooris G.S., O'Mahony C., Jiskoot W. & Bouwstra J.A. (2021), Engineering of an automated nano-droplet dispensing system for fabrication of antigen-loaded dissolving microneedle arrays, International Journal of Pharmaceutics 600: 120473.
- Heuts J.M.M., Jiskoot W., Ossendorp F.A. & Maaden K. van der (2021), Cationic nanoparticle-based cancer vaccines, Pharmaceutics 13(5): 596.
- Maaden K. van der, Schipper P., Jiskoot W. & Bouwstra J.A. (2019), Chemical Modifications of Gold Surfaces with Basic Groups and a Fluorescent Nanoparticle Adhesion Assay To Determine Their Surface pKa, Langmuir 35(22): 7121-7128.
- Maaden K. van der, Heuts J.M.M., Camps M.G.M., Pontier M.J., Terwisscha van Scheltinga A., Jiskoot W., Ossendorp F.A. & Bouwstra J.A. (2018), Hollow microneedle-mediated micro-injections of a liposomal HPV E7(43-63) synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses, Journal of Controlled Release 269: 347-354.
- Du G., Woythe L., Maaden K. van der, Leone M., Romeijn S.G., Kros A., Kersten G.F.A., Jiskoot W. & Bouwstra J.A. (2018), Coated and Hollow Microneedle-Mediated Intradermal Immunization in Mice with Diphtheria Toxoid Loaded Mesoporous Silica Nanoparticles, Pharmaceutical Research 35(10): 189.
- Heuts J.M.M., Varypataki E.M., Maaden K. van der, Romeijn S.G., Drijfhout J.W., Scheltinga A.T. van, Ossendorp F. & Jiskoot W. (2018), Cationic Liposomes: A Flexible Vaccine Delivery System for Physicochemically Diverse Antigenic Peptides, Pharmaceutical Research 35: 207.
- Leone M., Oorschot B.H. van, Nejadnik M.R., Bocchino A., Rosato M., Kersten G.F.A., O’Mahony C., Bouwstra J.A. & Maaden K. van der (2018), Universal applicator for digitally-controlled pressing force and impact velocity insertion of microneedles into skin, Pharmaceutics 10(4): 211-219.
- Tu J., Du G., Reza Nejadnik M., Monkare J.T., Maaden K. van der, Bomans P.H.H., Sommerdijk N.A.J.M., Slutter B., Jiskoot W., Bouwstra J.A. & Kros A. (2017), Mesoporous Silica Nanoparticle-Coated Microneedle Arrays for Intradermal Antigen Delivery, Pharmaceutical Research 34(8): 1693-1706.
- Schipper P., Maaden K. van der, Groeneveld V.G.D., Ruigrok M.J.R., Romeijn S.G., Uleman S., Oomens C., Kersten G.F.A., Jiskoot W. & Bouwstra J.A. (2017), Diphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice, Journal of Controlled Release 262: 28-36.
- Schipper P., Maaden K. van der, Romeijn S., Oomens C., Kersten G., Jiskoot W. & Bouwstra J. (2016), Repeated fractional intradermal dosing of an inactivated polio vaccine by a single hollow microneedle leads to superior immune responses, Journal of Controlled Release 242: 141-147.
- Schipper P., Maaden K. van der, Romeijn S.G., Oomens C., Kersten G.F.A., Jiskoot W. & Bouwstra J.A. (2016), Determination of depth-dependent intradermal immunogenicity of adjuvanted inactivated polio vaccine delivered by microinjections via hollow microneedles, Pharmaceutical Research 33: 2269-2279.
- Maaden K. van der, Luttge R., Vos P.J., Bouwstra J.A., Kersten G.F.A. & Ploemen I. (2015), Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays, Drug Delivery and Translational Research 5: 397-406.
- Maaden K. van der, Sekerdag E., Schipper P., Kersten G.F.A., Jiskoot W. & Bouwstra J.A. (2015), Layer-by-Layer Assembly of Inactivated Poliovirus and N-Trimethyl Chitosan on pH-Sensitive Microneedles for Dermal Vaccination, Langmuir 31(31): 8654-60.
- Varypataki E.M., Maaden K. van der, Bouwstra J.A., Ossendorp F.A. & Jiskoot W. (2015), Cationic liposomes loaded with a synthetic long peptide and poly(I:C): a defined adjuvanted vaccine for induction of antigen-specific T cell cytotoxicity, AAPS Journal 17(1): 216-226.
- Maaden K. van der, Trietsch S.J., Kraan H., Varypataki E.M., Romeijn S., Zwier R., Linden H.J. van der, Kersten G., Hankemeier T., Jiskoot W. & Bouwstra J. (2014), Novel Hollow Microneedle Technology for Depth-Controlled Microinjection-Mediated Dermal Vaccination: A Study with Polio Vaccine in Rats, 31(7): 1846-1854.
- Maaden Koen van der, Varypataki Eleni Maria, Yu Huixin, Romeijn Stefan, Jiskoot Wim & Bouwstra Joke (2014), Parameter optimization toward optimal microneedle-based dermal vaccination, 64: 18-25.
- Maaden K. van der, Varypataki E.M., Romeijn S.G., Ossendorp F.A., Jiskoot W. & Bouwstra J.A. (2014), Ovalbumin-coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice, European Journal of Pharmaceutics and Biopharmaceutics 88(2): 310-315.
- Maaden Koen van der, Tomar Jasmine, Jiskoot Wim & Bouwstra Joke (2014), Chemical Modifications of Silicon Surfaces for the Generation of a Tunable Surface Isoelectric Point, Langmuir 30(7): 1812-1819.
- Maaden Koen van der, Sekerdag Emine, Jiskoot Wim & Bouwstra Joke (2014), Impact-Insertion Applicator Improves Reliability of Skin Penetration by Solid Microneedle Arrays, AAPS Journal 16(4): 681-684.
- Maaden K. van der, Yu H., Sliedregt K., Zwier R., Leboux R., Oguri M., Kros A., Jiskoot W. & Bouwstra J.A. (2013), Nanolayered chemical modification of silicon surfaces with ionizable surface groups for pH-triggered protein adsorption and release: application to microneedles, Journal of Materials Chemistry B 1(35): 4466-4477.
- Maaden K. van der, Sliedregt K., Kros A., Jiskoot W. & Bouwstra J. (2012), Fluorescent Nanoparticle Adhesion Assay: a Novel Method for Surface pK(a) Determination of Self-Assembled Monolayers on Silicon Surfaces, Langmuir 28(7): 3403-3411.
- Maaden K. van der, Jiskoot W. & Bouwstra J.A. (2012), Microneedle technologies for (trans)dermal drug and vaccine delivery, Journal of Controlled Release 161(2): 645-655.
- Carstens M.G., Maaden K. van der, Velden D. van der, Ottenhoff T.H., Melief C.J., Ossendorp F., Bouwstra J.A. & Jiskoot W. (2011), Evaluation of the high-pressure extrusion technique as a method for sizing plasmid DNA-containing cationic liposomes, Journal of Liposome Research 21(4): 286-295.