James Stevens
Postdoc / guest
- Name
- Dr. J.L. Stevens
- Telephone
- 071 5276270
- j.l.stevens@lacdr.leidenuniv.nl
Postdoc / guest
- Faculty of Science
- LACDR
- Divisie Cell systems and Drug Safety
- Bruns I.B., Li Y., Stevens J.L., Water B. van de & Callegaro G. (2025), Cell type heterogeneity in gene co-expression networks: implications for toxicological research, Briefings in Bioinformatics 26(4): bbaf421.
- Goldring C.E., Russomanno G., Pin C., Trairatphisan P., Beattie K.A., Fisher C.P., Piñero J., Brennan R.J., Clausznitzer D., Copple I.M., Kok T.M. de, Duckworth C.A., Furlong L.I., Füzi B., Gabor A., Gall L., Hengstler J., Hermjakob H., Hunter F., Jennen D., Koskinen M., Kunnen S.J., Lammens L., Lobentanzer S., Mohr M., Passini E., Pritchard D.M., Malik-Sheriff R.S., Rodríguez B., Rossman E.I., Saez-Rodríguez J., Schmidt F., Sison-Young R., Soininen I., Turner S., Water B. van de, Hasselt J.G.C. van, Venezia F., Willy J.A., Leishman D.J., Stevens J.L. & Laplanche L. (2025), Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety, Nature Reviews Drug Discovery : .
- Stevens L.J., Steeg E. van de, Doppenberg J.B., Alwayn I.P.J., Knibbe C.A.J. & Dubbeld J. (2024), Ex vivo gut-hepato-biliary organ perfusion model to characterize oral absorption, gut-wall metabolism, pre-systemic hepatic metabolism and biliary excretion; application to midazolam, European Journal of Pharmaceutical Sciences 196: 106760.
- Stevens L.J., Dubbeld J., Doppenberg J.B., Hoek B. van, Menke A.L., Donkers J.M., Alsharaa A., Vries A.de, Vaes W.H.J., Knibbe C.A.J., Steeg E. van de & Alwayn I.P.J. (2023), Novel explanted human liver model to assess hepatic extraction, biliary excretion and transporter function, Clinical Pharmacology & Therapeutics 114(1): 137-147.
- Callegaro G., Schimming J.P., Piñero González J., Kunnen S.J., Wijaya L.S., Trairatphisan P., Berk L. van den, Beetsma K., Furlong L.I., Sutherland J.J., Mollon J., Stevens J.L. & Water B. van de (2023), Identifying multiscale translational safety biomarkers using a network-based systems approach, iScience 26(3): 106094.
- Wijaya L.S., Trairatphisan P., Gabor A., Niemeijer M.C., Keet J., Alcalà Morera A., Snijders K.E., Wink S., Yang H., Schildknecht S., Stevens J.L., Bouwman R.J.P., Kamp H., Hengstler J., Beltman J.B., Leist M., Le Dévédec S.E., Saez-Rodriguez J. & Water B. van de (2021), Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury, Biochemical Pharmacology 190: 114591.
- Callegaro G., Kunnen S.J., Trairatphisan P., Grosdidier S., Niemeijer M., Hollander W. den, Guney E., Piñero Gonzalez J., Furlong L., Webster Y.W., Saez-Rodriguez J., Sutherland J.J., Mollon J., Stevens J.L. & Water B. van de (2021), The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment, Archives of Toxicology 95(12): 3745-3775.