Huub Middelkoop
Professor
- Name
- Prof. dr. H.A.M. Middelkoop
- Telephone
- 071 5273656
- middelkoop@fsw.leidenuniv.nl
- ORCID iD
- 0000-0001-9205-2921
Professor
- Faculty of Social and Behavioural Sciences
- Psychology
- Health, Medical and Neuropsychology
- Egmond E.E.A. van, Hiele K. van der, Rooij M.J. de Gorp D.A.M. van, Jongen P.J., Klink J.J.L. van der, Reneman M.F., Beenakker E.A.C., Eijk J.J.J. van, Frequin S.T.F.M. , Gans K. de, Hoitsma E., Gerlach O.H.H., Mostert J.P., Verhagen W.I.M., Visser L.H. & Middelkoop H.A.M. (2024), Longitudinal determinants of employment status in people with relapsing-remitting multiple sclerosis, IBRO neuroscience reports 16: 518-526.
- Monahan R.C., Middelkoop H.A.M., Beaart‐van de Voorde L.J.J., Fronczek R., Groenwold R.H.H., Kloppenburg M., Huizinga T.W.J. & Steup‐Beekman G.M. (2023), High prevalence but low impact of cognitive dysfunction on quality of life in patients with lupus and neuropsychiatric symptoms, Arthritis Care & Research 75(5): 1017-1025.
- Wegen J. van, Egmond E.E.A. van, Benedict R.H.B., Beenakker E.A.C., Eijk J.J.J. van, Frequin S.T.F.M., Gans K. de, Gerlach O.H.H., Gorp D.A.M. van, Hengstman G.J.D., Jongen P.J., Klink J.J.L. van der, Reneman M.F., Verhagen W.I.M., Middelkoop H.A.M., Visser L.H., Hulst H.E. & Hiele K. van der (2022), Subjective cognitive impairment is related to work status in people with multiple sclerosis, IBRO neuroscience reports 13: 513-522.
- Egmond E.E.A. van, Hiele K. van der, Gorp D.A.M. van, Jongen P.J., Klink J.J.L. van der, Reneman M.F., Beenakker E.A.C., Eijk J.J.J. van, Frequin S.T.F.M., Gans K. de, Geel B.M. van, Gerlach O.H.H., Hengstman G.J.D., Mostert J.P., Verhagen W.I.M., Middelkoop H.A.M. & Visser L.H. (2022), Work difficulties in people with multiple sclerosis: the role of anxiety, depression and coping, Multiple Sclerosis Journal - Experimental, Translational and Clinical 8(3): 205521732211162.
- Egmond E.E A. van, Gorp D.A.M. van, Jongen P.J., Klink J.J.L. van der, Reneman M.F., Arnoldus E.P.J., Beenakker E.A.C., Eijk J.J.J. van, Frequin S.T.F.M., Gerlach O.H.H., Hengstman G.J.D., Moll J.W.B., Verhagen W.I.M., Middelkoop H.A.M., Visser L.H. & Hiele K. van der (2022), Self-reported work productivity in people with multiple sclerosis and its association with mental and physical health, Disability and Rehabilitation 44(23): 7096-7105.
- Van Hienen M.M., Kuiper R., Middelkoop H.A.M., Van Hilten J.J., Contarino M.F. & Geraedts V.J. (2022), Patient-related factors influencing caregiver burden in Parkinson’s disease patients: comparison of effects before and after deep brain stimulation, Journal of Parkinson's Disease 12(4): 1285-1293.
- Monahan R.C., Blonk A., Huizinga T.W., Kloppenburg M., Middelkoop H.A.M., van der Wee N. & Steup-Beekman G.M. (2022), To treat or not to treat with immunosuppressive therapy: psychiatric disorders in patients with systemic lupus erythematosus, Lupus Science & Medicine 9(1): e000629.
- Hiele K. van der, Gorp D.A.M. van, Egmond E.E.A. van, Jongen P.J., Reneman M.F., Van der Klink J., Arnoldus E., Beenakker E., Van Eijk J., Frequin S., Fe Gans K., Hengstman G., Hoitsma E., Gerlach O., Verhagen W., Heerings M., Middelkoop H.A.M. & Visser L.H. (2021), Self-reported occupational functioning in persons with relapsing-remitting multiple sclerosis: does personality matter?, Journal of the Neurological Sciences 427: 117561.
- Van Egmond E.E.A., Van Gorp D., Honan C., Heerings M., Jongen P., Van der Klink J., Reneman M., Beenakker E., Frequin S., De Gans K., Hengstman G., Hoitsma E., Mostert J., Verhagen W., Zemel D., Middelkoop H.A.M., Visser L. & Van der Hiele K. (2021), A Dutch validation study of the Multiple Sclerosis Work difficulties questionnaire in relapsing remitting multiple sclerosis, Disability and Rehabilitation 43(13): 1924-1933.
- Hiele K. van der, Egmond E. van, Jongen P., Klink J. van der, Beenakker E., Eijk J. van, Frequin S.T.F.M., Hoitsma E., Mostert J.P., Verhagen W.I.M., Gorp D.A.M. van, Middelkoop H.A.M. & Visser L. (2020), Empathy in multiple sclerosis - correlates with cognitive, psychological and occupational functioning, Multiple Sclerosis and Related Disorders 41: 102036.
- Van Gorp D.A.M., Van der Hiele K., Heerings M.A.P., Jongen P.J., Van der Klink J.J.L., Reneman M.F., Arnoldus E.P.J., Beenakker E.A.C., Van Eijk J.J.J., Frequin S.T.F.M., De Gans K., Hoitsma E., Mostert J.P., Verhagen W.I.M., Zemel D., Visser L.H. & Middelkoop H.A.M. (2019), Cognitive functioning and employment status in relapsing remitting multiple sclerosis: a 2-year longitudinal study, Neurological Sciences 40(12): 2555–2564.
- Van Gorp D.A.M., Van der Hiele K., Middelkoop H.A.M. & Visser L.H. (2019), The relation between cognitive functioning and work outcomes in patients with Multiple Sclerosis: a systematic literature review, Current Research in Neurology and Neurosurgery 2(1): 011-029.
- Van der Hiele K., Van Gorp D.A.M., Heerings M.A.P., Jongen P.J., Van der Klink J.J.L., Beenakker E.A.C., Van Eijk J.J.J., Frequin S.T.F.M., Van Geel B.M., Hengstman G.J.D., Hoitsma E., Mostert J.P., Verhagen W.I.M., De Gans K., Zemel D., Middelkoop H.A.M. & Visser L.H. (2019), Caregiver strain among life partners of persons with mild disability due to relapsing-remitting Multiple Sclerosis, Multiple Sclerosis and Related Disorders 31: 5-11.
- Gorp D.A.M. van, Klink J.J.L. van der, Abma F.I., Jongen P.J., Lieshout I. van, Arnoldus E.P.J., Beenakker E.A.C., Bos H.M., Eijk J.J.J. van, Fermont J., Frequin S.T.F.M., Gans K. de, Hengstman G.J.D., Hupperts R.M.M., Mostert J.P., Pop P.H.M., Verhagen W.I.M., Zemel D., Heerings M.A.P., Reneman M.F., Middelkoop H.A.M., Visser L.H. & Hiele K. van der (2018), The capability set for work - correlates of sustainable employability in workers with Multiple Sclerosis, Health and Quality of Life Outcomes 16: e113.
- Van Erp S., Ercan E., Breedveld P., Brakenhoff L., Ghariq E., Schmid S., Van Osch M., Van Buchem M., Emmer B., Van der Grond J., Wolterbeek R., Hommes D., Fidder H., Van der Wee N., Huizinga T., Van der Heijde D., Middelkoop H.A.M., Ronen I. & Van der Meulen-de Jong A. (2017), Cerebral magnetic resonance imaging in quiescent Crohn’s disease patients with fatigue, World Journal of Gastroenterology 23(6): 1018-1029.
- Magro-Checa C., Beaart-Van de Voorde L.J.J., Middelkoop H.A.M., Dane M.L., Van der Wee N.J., Van Buchem M.A., Huizinga T.W.J. & Steup-Beekman G.M. (2017), Outcomes of neuropsychiatric events in systemic lupus erythematosus based on clinical phenotypes; prospective data from the Leiden NP SLE cohort, Lupus 26(5): 543-551.
- Magro-Checa C., Zirkzee E.J., Beaart-Van de Voorde L.J.J., Middelkoop H.A.M., Van der Wee N.J., Huisman M.V., Eikenboom J., Kruyt N.D., Van Buchem M.A., Huizinga T.W.J. & Steup-Beekman G.M. (2017), Value of multidisciplinary reassessment in attribution of neuropsychiatric events to systemic lupus erythematosus: Prospective data from the Leiden NPSLE cohort, Rheumatology 56(10): 1676-1683.
- Van der Hiele K., Gorp D.A.M. van, Benedict R.H.B., Jongen P.J., Arnoldus E.P.J., Beenakker E.A.C., Bos H.M., Eijk J.J.J. van, Fermont J., Frequin S.T.F.M., Geel B.M. van, Hengstman G.J.D., Hoitsma E., Hupperts R.M.M., Mostert J.P., Pop P.H.M., Verhagen W.I.M., Zemel D., Frndak S.E., Heerings M.A.P., Middelkoop H.A.M. & Visser L.H. (2016), Coping strategies in relation to negative work events and accommodations in employed multiple sclerosis patients, Multiple Sclerosis Journal - Experimental, Translational and Clinical 2016(2): 1-9.
- Van der Hiele K., Gorp D.A.M. van, Lieshout I. van, Jongen P.J., Heerings M.A.P., Middelkoop H.A.M. & Visser L.H. (2016), Factoren van invloed op arbeidsparticipatie bij patiënten met Multiple Sclerose, Tijdschrift voor Neurologie en Neurochirurgie 117(1): 5-10.
- Joustra S.D., Andela C.D., Oostdijk W., Van Trotsenburg A.S., Fliers E., Wit J.M., Pereira A.M., Middelkoop H.A.M. & Biermasz N.R. (2016), Mild deficits in attentional control in patients with the IGSF1 deficiency syndrome, Clinical Endocrinology 84(6): 896-903.
- Van Rooden S., Van Opstal A.M., Labadie G., Terwindt G.M., Wermer M.J., Webb A.G., Middelkoop H.A.M., Greenberg S.M., Van der Grond J. & Van Buchem M.A. (2016), Early magnetic resonance imaging and cognitive markers of hereditary cerebral amyloid angiopathy, Stroke 47(12): 3041-3044.
- Magro-Checa C., Ercan E., Wolterbeek R., Emmer B., Van der Wee N.J., Middelkoop H.A.M., Kruyt N.D., Ronen I., Van Buchem M.A., Huizinga T.W. & Steup-Beekman G.M. (2016), Changes in white matter microstructure suggest an inflammatory origin of neuropsychiatric systemic lupus erythematosus, Arthritis & Rheumatology 68(8): 1945-1954.
- Van Rooden S., Buijs M., Van Vliet M.E., Versluis M.J., Webb A.G., Oleksik A.M., Van de Wiel L., Middelkoop H.A.M., Blauw G.J., Weverling-Rynsburger A.W., Goos J.D., Van der Flier W.M., Koene T., Scheltens P., Barkhof F., Van de Rest O., Slagboom P.E., Van Buchem M.A. & Van der Grond J. (2016), Cortical phase changes measured using 7-T MRI in subjects with subjective cognitive impairment, and their association with cognitive function, NMR in Biomedicine 29(9): 1289-1294.
- Van der Hiele K., Van Gorp D.A., Van Lieshout I., Jongen P.J., Heerings M.A., Middelkoop H.A. & Visser L.H. (2016), Factoren van invloed op arbeidsparticipatie bij patiënten met multiple sclerose, Tijdschrift voor Neurologie en Neurochirurgie 117: 5-10.
- Van der Hiele K., Van Gorp D.A.M., Heerings M.A.P., Van Lieshout I., Jongen P.J., Reneman M.F., Van der Klink J.J.L., Vosman F., Middelkoop H.A.M. & Visser L.H. (2015), The MS@Work study: A 3-year prospective observational study on factors involved with work participation in patients with relapsing-remitting Multiple Sclerosis, BMC Neurology 15: e134.
- Van der Hiele K., Van Gorp D., Ruimschotel R., Kamminga N., Visser L. & Middelkoop H. (2015), Work participation and executive abilities in patients with relapsing-remitting Multiple Sclerosis, PLoS ONE 10(6): e0129228.
- Moonen J.E.F., Foster-Dingley J.C., De Ruijter W., Van der Grond J., Bertens A.S., Van Buchem M.A., Gussekloo J., Middelkoop H.A., Wermer M.J.H., Westendorp R.G.J., De Craen A.J.M. & Van der Mast R.C. (2015), Effect of discontinuation of antihypertensive treatment in elderly people on cognitive functioning- the DANTE Study Leiden: A randomized clinical trial, JAMA Internal Medicine 175(10): 1622-1630.
- Sala M., De Roos A., Blauw G.J., Middelkoop H.A.M., Jukema J.W., Mooijaart S.P., Van Buchem M.A., De Craen A.J.M. & Van der Grond J. (2015), Association between changes in brain microstructure and cognition in older subjects at increased risk for vascular disease, BMC Neurology 15: e133.
- Hart E.P., Dumas E.M., Van Zwet E.W., Van der Hiele K., Jurgens C.K., Middelkoop H.A., Van Dijk J.G. & Roos R.A. (2015), Longitudinal pilot-study of sustained attention to response task and P300 manifest and pre-manifest Huntington's disease, Neuropsychology 9(1): 10-20.
- Zirkzee E.J.M., Huizinga T.W.J., Bollen E.L.E.M., Van Buchem M.A., Middelkoop H.A.M., Van der Wee N.J.A., Le Cessie S. & Steup-Beekman G.M. (2014), Mortality in neuropsychiatric systemic lupus erythematosus (NPSLE), Lupus 23(1): 31-38.
- El Hachioui H., Visch-Brink E.G., Lingsma H.F., Van de Sandt-Koenderman M.W.M.E., Dippel D.W.J., Koudstaal P.J. & Middelkoop H.A.M. (2014), Nonlinguistic cognitive impairment in poststroke aphasia: A prospective study, Neurorehabilitation and Neural Repair 28(3): 273-281.
- Van der Hiele K., Middelkoop H.A.M., Ruimschotel R., Kamminga N.G.A. & Visser L.H. (2014), A pilot study on factors involved with work participation in the early stages of multiple sclerosis, PLoS ONE 9(8): e105673.
- Dumas E.M., Van den Bogaard S.J., Middelkoop H.A. & Roos R.A. (2013), A review of cognition in Huntington's disease, Frontiers in Bioscience S5: 1-18.
- Blackwell S.E., Rius-Ottenheim N., Schulte-Van Maaren Y.W.M., Carlier I.V.E., Middelkoop H.A.M., Zitman F.G., Spinhoven P., Holmes E.A. & Giltay E.J. (2013), Optimism and mental imagery: A possible cognitive marker to promote well-being?, Psychiatry Research 206: 56-61.
- Hafkemeijer A., Altmann-Schneider I., Oleksik A.M., Wiel L. van de, Middelkoop H.A., Buchem M.A. van, Grond J. van der & Rombouts S.A. (2013), Increased functional connectivity and brain atrophy in elderly with subjective memory complaints, Brain Connectivity 3(4): 353-362.
- Palm W.M., Ferrarini L., Van der Flier W.M., Westendorp R.G., Bollen E.L., Middelkoop H.A., Milles J.R., Van der Grond J. & Van Buchem M.A. (2013), Cerebral atrophy in elderly with subjective memory complaints, Journal of Magnetic Resonance Imaging 38(2): 358-364.
- Hiele K. van der, Spliethoff-Kamminga N.G., Ruimschotel R.P., Middelkoop H.A.M. & Visser L.H. (2012), The relationship between self-reported executive performance and psychological characteristics in multiple sclerosis, European Journal of Neurology 19(4): 562-569.
- Hiele K. van der, Spliethoff-Kamminga N.G.A., Ruimschotel R.P., Middelkoop H.A.M. & Visser L.H. (2012), Daily hassles in Dutch Multiple Sclerosis patients, Journal of the Neurological Sciences 320(1-2): 85-90.
- Hart E.P., Dumas E.M., Reijntjes R.H., Hiele K. van der, Bogaard S.J., Middelkoop H.A.M., Roos R.A. & Van Dijk G.J. (2012), Deficient sustained attention to response task and P300 characteristics in early Huntington's disease, Journal of Neurology 259(6): 1191-1198.
- Jurgens C.K., Van der Hiele K., Reijntjes R.H., Van de Wiel L., Witjes-Ané M.N., Van der Grond J., Roos R.A., Middelkoop H.A.M. & Van Dijk J.G. (2011), Basal ganglia volume is strongly related to P3 event-related potential in premanifest Huntington's disease, European Journal of Neurology 18(8): 1105-1108.
- Tiemensma J., Biermasz N.R., Van der Mast R.C., Wassenaar M.J.E., Middelkoop H.A.M., Pereira A.M. & Romijn J.A. (2010), Increased psychopathology and maladaptive personality traits, but normal cognitive functioning, in patients after long-term cure of acromegaly, Journal of Clinical Endocrinology and Metabolism 95(12): E392-E402.
- Tiemensma J., Biermasz N.R., Middelkoop H.A.M., Mast R.C. van der, Romijn J.A. & Pereira A.M. (2010), Increased prevalence of psychopathology and maladaptive ersonality traits after long-term cure of Cushing's disease, Journal of Clinical Endocrinology and Metabolism 95(10): E129-E141.
- Jurgens C.K., Jasinschi R., Ekin A., Witjes-Ané M.N., Middelkoop H.A.M., Grond J. van der & Roos R.A. (2010), MRI T2 Hypointensities in basal ganglia of premanifest Huntington's disease, PLoS Currents 8(2): RRN 1173.
- Tiemensma J., Kokshoorn N.E., Biermasz N.R., Keijser B.J.F., Wassenaar M.J.E., Middelkoop H.A.M., Pereira A.M. & Romijn J.A. (2010), Subtle cognitive impairments in patients with long-term cure of Cushing's disease, Journal of Clinical Endocrinology and Metabolism 95(6): 2699-2714.
- Jurgens C.K., Bos R., Luyendijk J., Witjes-Ané M.N., Grond J. van der, Middelkoop H.A.M. & Roos R.A. (2010), Magnetization transfer imaging in 'premanifest' Huntingtons' disease, Journal of Neurology 257(3): 426-432.
- Elderen S.G., Roos A. de, Craen AJ de, Westendorp R.G.J., Blauw G.J., Jukema J.W., Bollen E.L., Middelkoop H.A.M., Buchem M.A. van & Grond J. van der (2010), Progression of brain atrophy ann cognitive decline in diabetes mellitus: a 3- year follow- uo, NEUROLOGY 75(11): 997-1002.
- Liem M.K., Lesnik Oberstein S.A.J., Haan J., Van der Neut I., Ferrari M.D., Van Buchem M.A., Middelkoop H.A.M. & Van der Grond J. (2009), MRI correlates of cognitive decline in CADASIL: a 7-year follow-up study, NEUROLOGY 72(2): 143-148.
- Es A.C.G.M. van, Flier W.M. van der, Box F.M.A., Middelkoop H.A.M., Westendorp R.G.J., Buchem M.A. van & Grond J. van der (2009), Carotid and basilar artery wall shear stress in Alzheimer's disease and mild cognitive impairment, Dementia and Geriatric Cognitive Disorders 28(3): 220-224.
- Van der Hiele K., Bollen E.L.E.M., Vein A.A., Reijntjes R.H.A.M., Westendorp R.G.J., Buchem M.A. van, Middelkoop H.A.M. & Dijk J.G. van (2008), EEG markers of future cognitive performance in the elderly, Journal of Clinical Neurophysiology 25(2): 83-89.
- Thijs R.D., Wagenaar W.A., Middelkoop H.A.M., Wieling W. & Van Dijk J.G. (2008), Transient loss of consciousness through the eyes of a witness, NEUROLOGY 71((21)): 1713-1718.
- Van der Hiele K., Middelkoop H.A. & Dijk J.G. van (2008), Het ‘zwakke plekken’ -EEG als voorspeller van de ziekte van Alzheimer, Neuropraxis 5(12): 154-159.
- Ferrarini L., Palm W.M., Olofsen H., Landen R. van der, Blauw G.J., Westendorp R.G.J., Bollen E.L.E.M., Middelkoop H.A.M., Reiber J.H., Buchem M.A. van & Admiraal-Behloul F. (2008), MMSE scores correlate with local ventricular enlargement in the spectrum from cognitively normal to Alzheimer disease, NEUROIMAGE 39(4): 1832-1838.
- Verbaan D., Marinus J., Visser M., Rooden S.M. van, Stiggelbout A.M., Middelkoop H.A.M. & Hilten J.J. van (2007), Cognitive impairment in Parkinson's disease, Journal of Neurology, Neurosurgery and Psychiatry 78(11): 1182-1187.
- Bijl A.E. van der, Emmer B.J., Breedveld F.C., Middelkoop H.A.M., Jurgens C.K., Buchem M.A. van, Huizinga T.W.J. & Grond J. van der (2007), Advanced magnetic resonance imaging of the brain in patients treated with TNF-alpha blocking agents, Clinical and Experimental Rheumatology 25(2): 301-304.
- Liem M.K., Grond J. van der, Haan J., Boom R. van den, Ferrari M.D., Knaap Y.M., Breuning M.H., Buchem M.A. van, Middelkoop H.A.M., Middelkoop H.A.M. & Lesnik S.A.J. (2007), Lacunar infarct are the main correlate with cognitive dysfunction in CADASIL, Stroke 38(3): 923-928.
- Es A.C.G.M. van, Flier W.M. van der, Admiraal-Behloul F., Olofsen H., Bollen E.L.E.M., Middelkoop H.A.M., Weverling-Rijnsburger A.W.E., Grond J. van der, Westendorp R.G.J. & Buchem M.A. van (2007), Lobar distribution of changes in gray matter and white matter in memory clinic patients: Detected using magnetization transfer imaging, American Journal of Neuroradiology 28(10): 1938-1942.
- Bijl A.E. van der, Emmer B.J., Breedveld F.C., Middelkoop H.A.M., Jurgens C.K., Buchem M.A. van, Huizinga T.W.J. & Grond J. van der (2007), Advanced magnetic resonance imaging of the brain in patients treated with TNF-alpha blocking agents, Clinical and Experimental Rheumatology 25(2): 301-304.
- Van der Hiele K., Vein A.A., Reijntjes R.H.A.M., Westendorp R.G.J., Bollen E.L.E.M., Buchem M.A. van, Dijk J.G. van & Middelkoop H.A.M. (2007), EEG correlates in the spectrum of cognitive decline, Clinical Neurophysiology 118(9): 1931-1939.
- Liem M.K., Grond J. van der, Haan J., Boom R. van den, Ferrari M.D., Knaap Y.M., Breuning M.H., Buchem M.A. van, Middelkoop H.A.M. & Lesnik Oberstein S.A.J. (2007), Lacunar infarcts are the main correlate with cognitive dysfunction in CADASIL, Stroke 38(3): 923-928.
- Verbaan D., Marinus J., Visser M., Rooden S.M. van, Stiggelbout A.M., Middelkoop H.A. & Hilten J.J. van (2007), Cognitive impairment in Parkinson's disease, Journal of Neurology, Neurosurgery and Psychiatry 78(11): 1182-1187.
- Liem M.K., Grond J. van der, Haan J., Boom R. van den, Ferrari M.D., Knaap Y.M., Breuning M.H., Buchem M.A. van, Middelkoop H.A.M. & Lesnik Oberstein S.A.J. (2007), Lacunar Infarcts Are the Main Correlate With Cognitive Dysfunction in CADASIL, Stroke 38: 923-928.
- Bijl A.E. van der, Emmer B.J., Breedveld F.C., Middelkoop H.A.M., Jurgens C.K., Buchem M.A. van, Huizinga T.W.J. & Grond J. van der (2007), Advanced magnetic resonance imaging of the brain in patients treated with TNF-alpha blocking agents, Clinical and Experimental Rheumatology 25(2): 301-304.
- Verbaan D., Marinus J., Visser M., Rooden S.M. van, Stiggelbout A.M., Middelkoop H.A.M. & Hilten J.J. van (2007), Cognitive impairment in Parkinson's disease, Journal of Neurology, Neurosurgery and Psychiatry 78(11): 1182-1187.
- Es A.C.G.M. van, Flier W.M. van der, Admiraal-Behloul F., Olofsen H., Bollen E.L.E.M., Middelkoop H.A.M., Middelkoop H.A.M., Weverling-Rijnsburger A.W.E., Grond J. van der, Westendorp R.G.J. & Buchem M.A. van (2007), Lobar distribution of changes in gray matter and white matter in memory clinic patients: detected using magnetization transfer imaging, American Journal of Neuroradiology 28: 1938-1942.
- Liem M.K., Grond J. van der, Haan J., Boom R. van den, Ferrari M.D., Knaap Y.M., Breuning M.H., Buchem M.A. van, Middelkoop H.A.M. & Lesnik Oberstein S.A. (2007), Lacunar infarcts are the main correlate with cognitive dysfunction in CADASIL, Stroke 38: 923-928.
- Es A.C.G.M. van, Flier W.M. van der, Admiraal-Behloul F., Olofsen H., Bollen E.L.E.M., Middelkoop H.A.M., Weverling-Rijnsburger A.W.E., Grond J. van der, Westendorp R.G.J. & Buchem M.A. van (2007), Lobar distribution of changes in gray matter and white matter in memory clinic: detected using magnetization transfer imaging, American Journal of Neuroradiology 28(10): 1938-1942.
- Bijl A.E. van der, Emmer B.J., Breedveld F.C., Middelkoop H.A.M., Jurgens C.K., Buchem M.A. van, Huizinga T.W.J. & Grond J. van der (2007), Advanced magnetic resonance imaging of the bain in patients treated with TNF-alpha blocking agents, Clinical and Experimental Rheumatology 25(2): 301-304.
- Van der Hiele K., Vein A.A., Welle Van der A, Grond J. van der, Westendorp R.G.J., Bollen E.L.E.M., Buchem M.A. van, Dijk J.G. van & Middelkoop H.A.M. (2007), EEG and MRI correlates of mild cognitive impairment and Alzheimer's disease, Neurobiology of Aging 28(9): 1322-1329.
- Middelkoop H.A.M. & Wekking E.M. (2006), Neuropsychologische aspecten van het dementiesyndroom. In: Engberts D.P. & Leeuwen E. van (Eds.), Medisch-ethische casuistuek-5: De dementerende patient in verpleeghuis en huisartsenpraktijk.. Leiden: Boerhaavecommissie. 5-15.
- Middelkoop H.A.M., Wekking E.M. & Zijlstra H.P. (2006), Klinische Neurospychologie. In: Kaptein A.A., Erdman R.A.M., Prins J.B. & Wiel H.B.M. van de (Eds.), Medische Psychologie. Houten: Bohn Stafleu van Loghum.
- Fronczek R., Middelkoop H.A.M., Van Dijk J.G. & Lammers G.J. (2006), Focussing on vigilance instead of sleepiness in the assessment of narolepsy:high sensitivity of the Sustained Attention to Response Task (SART), Sleep 29(2): 187-191.
- Middelkoop H.A.M., Wekking E.M. & Zijlstra H.P. (2006), Klinische neuropsychologie. In: Kaptein A.A, Erdman R.A.M, Prins J.B & Wiel H.B.M. van de (Eds.), Medische Psychologie. Houten: Bohn stafleu van Loghum. 87-98.
- Verbaan D., Visser M., Marinus J., Rooden S., Stiggelhout A., Middelkoop H.A.M. & Hilten J. van (2006), Cognitive impairment in Parkinson's disease: Characteristics and the relation with clinical manifestations, Movement Disorders 21: S490.
- Palm W.M., Walchenbach R., Bruinsma B., Admiraal-Behloul F., Middelkoop H.A.M., Launer L.J., Grond J. van der & Buchem M.A. van (2006), Intracranial compartment volumes in Normal Pressure Hydrocephalus: Volumetric assessment verus outcome, American Journal of Neuroradiology 27(1): 76-79.
- Middelkoop H.A.M. & Wekking E.M. (2006), Neuropsychologische aspecten van het dementiesyndroom, Modern Medicine 30(6): 237-241.
- Middelkoop H.A.M. (2006), De neuropsychologie van de "evidence based practice" in de manuele therapie, Nederlands Tijdschrift voor Manuele Therapie 3(2): 47.
- Palm W.M., Walchenbach R., Bruinsma B., Admiraal-Behloul F., Launer L.L., Middelkoop H.A.M., Grond J. van der & Buchem M.A. van (2006), Intracranial compartment volumes in Normal Pressure Hydrocephalus: Volumetric assessment versus outcome, American Journal of Neuroradiology 27(1): 76-79.
- Es A.C.G.M. van, Flier W.M. van der, Admiraal-Behloul F., Olofsen H., Bollen E.L.E.M., Middelkoop H.A.M., Weverling-Rijnsburger A.W.E., Westendorp R.G.J. & Buchem M.A. van (2006), Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease, Neurobiology of Aging 27: 1757-1762.
- Montagne B., Kessels R.P., Kammers M.P., Kingma E., Haan E.H. de, Roos R.A.C. & Middelkoop H.A.M. (2006), Perception of emotional facial expressions at different intensities in early-symptomatic Huntington's disease, European Neurology 55(3): 151-154.
- Fronczek R., Middelkoop H.A.M., Dijk J.G. van & Lammers G.J. (2006), Focusing on vigilance instead of sleepiness in the assessment of narcolepsy: high sensitivity of the Sustained Attention to Response Task (SART), Sleep 29(2): 187-191.
- Es A.C.G.M. van, Flier W.M. van der, Admiraal-Behloul F., Olofsen H., Bollen E.L.E.M., Middelkoop H.A.M., Weverling-Rijnsburger A.W.E., Westendorp R.G.J. & Buchem M.A. van (2005), Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease, Neurobiology of Aging : .
- Flier W.M. van der, Middelkoop H.A.M., Weverling-Rijnsburger A.W.E., Admiraal-Behloul F., Bollen E.L.E.M., Westendorp R.G.J. & Buchem M.A. van (2005), Neuropsychological correlates of MRI measures in the continuum of cognitive decline at old age, Dementia and Geriatric Cognitive Disorders 20: 82-88.
- Flier W.M. van der, Vlies A.E., Weverling-Rijnsburger A.W.E., Boer N.L. de, Admiraal-Behloul F., Bollen E.L.E.M., Westendorp R.G.J., Buchem M.A. van & Middelkoop H.A.M. (2005), MRI measures and progression of cognitive decline in nondemented elderly attending a memory clinic, International Journal of Geriatric Psychiatry 20(11): 1060-1066.
- Flier W.M. van der, Middelkoop H.A.M., Weverling-Rijnsburger A.W.E., Bollen E.L.E.M., Westendorp R.G.J. & Buchem M.A. van (2005), MRI measures and progression of cognitive decline in nondemented elderly attending a memory clinic, International Journal of Geriatric Psychiatry 20: 1060-1066.
- Flier W.M. van der, Middelkoop H.A.M., Weverling-Rijnsburger A.W.E., Admiraal-Behloul F., Bollen E.L.E.M., Westendorp R.G.J. & Buchem M.A. van (2005), Neuropsychological correlates of MRI measures in the continuum of cognitive decline at old age, Dementia and Geriatric Cognitive Disorders 20: 82-88.
- Spilt A., Weverling-Rijnsburger A.W.E., Middelkoop H.A.M., Flier W.M. van der, Gussekloo J., Craen AJ de, Bollen E.L.E.M., Blauw G.J., Buchem M.A. van & Westendorp R.G.J. (2005), Late-onset dementia: structural brain damage and total cerebral blood flow, Radiology 236: 990-995.
- Spilt A., Weverling Rijnsburger A.W., Middelkoop H.A.M., Flier W.M. van der, Gussekloo J., Craen A.J.M. de, Bollen E.L., Blauw G.J., Buchem M.A. van & Westendorp R.G.J. (2005), Late-onset dementia: structural brain damage and total cerebral blood flow, Radiology 236: 990-995.
- Middelkoop H.A.M., Broek P., Brouwer A, Deeg DJ, Frenken J., Hendriks H.F.J., Heuvel W.J.A. van den, Hopman-Rock M., Jolles J., Kamphuisen H.A.C., Kemp B., Kerhof G.A., Slagboom E., Sweden B, Vijg J., Visser A.P. & Weeda H.W. (2004), De Leer van de Veroudering: Gerontologie. In: Eulderink F., Heeren T.J., Knook D.L. & Ligthart G.J. (Eds.), Inleiding Gerontologie en Geriatrie (4e druk). Houten/Zaventem: Bohn Stafleu Van Loghum.
- Flier W.M. van der, Buchem M.A. van, Weverling-Rijnsburger A.W.E., Mutsaers E.R., Bollen E.L.E.M., Admiraal-Behloul F., Westendorp R.G.J. & Middelkoop H.A.M. (2004), Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes, Journal of Neurology 251(6): 671-675.
- Verhey F.R., Houx P., Lang N. van, Huppert F.A., Stoppe G., Saerens J., Bohm P., Vreese L. de, Nordlund A., DeDeyn P.P., Neri M., Pena-Casanova J., Wallin A., Bollen E.L.E.M., Middelkoop H.A.M., Nargeot C., Puel M.C., Fleischmann U.M. & Jolles J. (2004), Cross-national comparison and validation of the Alzheimer's Disease Assessment Scale: results from the European Harmonization Project for Instruments in Dementia (EURO-HARPID), International Journal of Geriatric Psychiatry 19(1): 41-50.
- Flier W.M. van der, Middelkoop H.A.M., Weverling-Rijnsburger A.W.E., Admiraal-Behloul F., Spilt A., Bollen E.L.E.M., Westendorp R.G.J. & Buchem M.A. van (2004), Interaction of medial temporal lobe atrophy and white matter hyperintensities in AD, NEUROLOGY 25(62(10)): 1862-1864.
- Visch-Brink E.G., Hagelstein M., Middelkoop H.A.M. & Cammen T.M.J. van der (2004), Naming and semantic processing in Alzheimer dementia: A coherent picture?, Brain and Language 91(1): 11-12.
- Vugt J.P.P. van, Piet K.K.E., Vink L., Siesling S., Zwinderman A.H., Middelkoop H.A.M. & Roos R.A.C. (2004), Objective assessment of motor slowness in Huntington's disease: clinical correlates and two years follow-up, Movement Disorders 19(3): 285-297.
- Flier W.M. van der, Middelkoop H.A.M., Weverling-Rijnsburger A.W.E., Admiraal-Behloul F., Spilt A., Bollen E.L.E.M., Westendorp R.G.J. & Buchem M.A. van (2004), Interaction of medial temporal lobe atrophy and white matter hyperintensities in AD, NEUROLOGY 62(10): 1862-1864.
- Lesnik Oberstein S.A.J., Boom R. van den, Middelkoop H.A.M., Ferrari M.D., Knaap Y.M., Houwelingen H.C. van, Breuning M.H., Buchem M.A. van & Haan J. (2003), Incipient CADASIL, Archives of Neurology -Chigago- 60: 707-712.
- Lesnik Oberstein S.A.J., Boom R. van den, Middelkoop H.A.M., Knaap Y.M., Ferrari M.D., Breuning M.H., Buchem M.A. van & Haan J. (2003), Incipient CADASIL, Archives of Neurology -Chigago- 60(5): 707-712.
- Marinus J., Visser M., Verwey N.A., Verhey F.R., Middelkoop H.A.M., Stiggelbout A.M. & Hilten J.J. van (2003), Assessment of cognition in Parkinson's disease, NEUROLOGY 61: 1222-1228.
- Verhey F.R.J., Houx P., Lang N. van, Huppert F.A., Stoppe G., Saerens J., Bohm P., Vreese L. de, Hellstrom P., DeDeyn P.P., Neri M., Pena-Casanova J., Wallin A., Bollen E.L.E.M., Middelkoop H.A.M., Nargeot C., Puel M. & Jolles J. (2003), Cross-national comparisons of the Cambridge Cognitive Examination-revised: the Camcog-R. Results from the European Harmonization Project for instruments in dementia, Age and Ageing 32: 534-540.
- Marinus J., Visser M., Verwey N.A., Verhey F.R., Middelkoop H.A.M., Stiggelbout A.M. & Hilten J.J. van (2003), Assessment of cognition in Parkinson's disease, NEUROLOGY 11(61): 1222-1228.
- Flier W.M. van der, Buchem M.A. van & Middelkoop H.A.M. (2003), Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease, NEUROLOGY 60(9): 1558.
- Lesnik Oberstein S.A.J., Boom R. van den, Middelkoop H.A.M., Ferrari M.D., Knaap Y.M., Houwelingen H.C. van, Breuning M.H., Buchem M.A. van & Haan J. (2003), Incipient CADASIL, Archives of Neurology -Chigago- 60: 707-712.
- Marinus J., Visser M., Verwey N.A., Verhey F.R.J., Middelkoop H.A.M., Stiggelbout A.M. & Hilten J.J. van (2003), Development of an instrument for the assessment of cognition in Parkinson's Disease, NEUROLOGY 61(9): 1222-1228.
- Middelkoop H.A.M. (24 May 2002). Hersencartografie. Leiden. [inaugural address].
- Kooij J.J., Middelkoop H.A.M. & Gils K. van (2002), The effect of stimulants on nocturnal motor activity and sleep quality in adults with ADHD: an open-label case-control study, Journal of Clinical Psychiatry 62: 952-956.
- Berg R van den, Bollen E.L.E.M., Knaap Y.M., Middelkoop H.A.M. & Overbeek O.M. (2002), Treatment of type III dural arteriovenous malformation: correlation with neuropsychological disturbances, Interventional Neuroradiology 8: 25-30.
- Bosma G.P.T., Middelkoop H.A.M., Rood M.J., Bollen E.L.E.M., Huizinga T.W.J. & Buchem M.A. van (2002), Association of global brain damage and clinical functioning in neuropsychiatric systemic lupus erythematosus, Arthritis & Rheumatology 46(10): 2665-2672.
- Vugt J.P.P. van, Siesling S., Piet K.K.E., Zwinderman A.H., Middelkoop H.A.M., Hilten J.J. van & Roos R.A.C. (2001), Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease, Movement Disorders 16: 481-488.
- Vugt J.P.P. van, Siesling S., Piet K.K.E., Zwinderman A.H., Middelkoop H.A.M., Hilten J.J. van & Roos R.A.C. (2001), Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease, Movement Disorders 16(3): 481-488.
- Middelkoop H.A.M., Flier W.M. van der, Burton E.J., Lloyd A.J., Paling S., Barber R., Ballard C. & McKeith I.G. (2001), Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI, NEUROLOGY 57: 2117-2120.
- Van den Heuvel D.M.J., Flier W.M. van der, Bollen E.L.E.M., Buchem M.A. van & Middelkoop H.A.M. (2001), Hippocampal volume and cognition in geriatric depression, Biological Psychiatry 50: 68-69.
- Hilten J.J. van, Beek W.J.T. van de, Vein A.A., Dijk J.G. van & Middelkoop H.A.M. (2001), Clinical aspects of multifocal or generalized tonic dystonia in reflex sympathetic dystrophy, NEUROLOGY 56: 1762-1765.
- Kooij J.J., Middelkoop H.A.M., Gils K. van & Buitelaar J.K. (2001), The effect of stimulants on nocturnal motor activity and sleep quality in adults with ADHD: an open-label case-control study, Journal of Clinical Psychiatry 62: 952-956.
- Roon K.I., Bakker D., Poelgeest M.I.E. van, Buchem M.A. van, Ferrari M.D. & Middelkoop H.A.M. (2000), The influence of ergotamine abuse on phychological and cognitive functioning, Cephalalgia 20(5): 462-469.
- Roon K.I., Bakker D., Poelgeest M.I.E. van, Buchem M.A. van, Ferrari M.D. & Middelkoop H.A.M. (2000), The influence of ergotamine abuse on psychological and congitive funtioning, Cephalalgia 20: 462-469.
- Verhey F.R.J., Bollen E.L.E.M., Middelkoop H.A.M. & Euro-Harpid proj.group (1999), Klinische relevantie van het gebruik van meetinstrumenten in de psychogeriatrie, IIIth PUK symp. 'Diagnostiek, epidemiologie + neurobiologie v. normale + pathologische ver : .
- Bosma G.P.T., Nierop N. van, Bollen E.L.E.M., Breedveld F.C., Middelkoop H.A.M., Huizinga T.W.J. & Buchem M.A. van (1999), Correlation of volumetric magnetization transfer imaging (MTI) with clinical functioning in neuropsychiatric systemic lupus erythematosus (NP-SLE), American College of Rheumatology 1999 Annual Meeting : .
- Verhey F.R.J., Bollen E.L.E.M., Middelkoop H.A.M. & European Harmonization Project for Instruments in Dementia project group (1999), European harmonisation project of instruments for dementia (Euro-Harpid), Proceedings Int. symposium 'Early interventions in dementia'. Hull, U.K. : .
- Vugt J.P.P. van, Siesling S., Piet K.K.E., Zwinderman A.H., Middelkoop H.A.M., Hilten J.J. van & Roos R.A.C. (1999), Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease, Proceedings 18th International meeting of the WFN Research Group on Huntington's Disease. : 15.
- Passchier-Vermeer W., Gils K. van, Vos H. de, Miedema H.M.E., Roo F. de, Verhoeff E. & Middelkoop H.A.M. (1999), Aircraft noise and sleep disturbance, TNO Prevention and Health Report PG/VGZ : 98.040.
- Middelkoop H.A.M. (1999), Concentratieproblemen, Psychometrika 34(2): 63.
- Bosma G.P.T., Buchem M.A. van, Rood M.J., Nierop N. van, Bollen E.L.E.M., Middelkoop H.A.M. & Huizinga T.W.J. (1999), Correlation of volumetric magnetization transfer imaging (MTI) with neuropsychological functioning in neuropsychiatric systemic lupus erythematosus (NP-SLE), Radiologendagen, Veldhoven : .
- Knuistingh Neven A., Middelkoop H.A.M., Kemp B., Kamphuisen H.A.C. & Springer M.P. (1998), Morning headaches and sleep apnoea syndrome. In: Beersma D.G.M., Bemmel A.L. van, Folgering H., Hofman W.F. & Ruigt G.S.F. (Eds.), Sleep-wake research in the Netherlands.. Utrecht: Elinkwijk. 83-85.
- Middelkoop H.A.M. (1998), The impact of Hilbert Kamphuisen on sleep research. In: Weert A. de, Kemp B. & Schimsheimer R.J. (Eds.), Liber Amicorum Hilbert Kamphuisen.. Den Haag: Pasmans. 56-58.
- Roos-Van Eijndhoven D.G., Middelkoop H.A.M. & Cools H.J.M. (1998), Long-term ambulatory monitoring of bladder temperature in older people: a pilot study, Journal of the American Geriatrics Society 46: 1583-1584.
- Middelkoop H.A.M. (1998), De MMPI-2 overdiagnostiseert psychotische gedragskenmerken bij vrouwen met een posttraumatische stress stoornis (PTSS), Psychologie en Computers 15: 116-118.
- Knuistingh Neven A., Middelkoop H.A.M., Kemp B., Kamphuisen H.A.C. & Springer M.P. (1998), The prevalence of sleep apnoea syndrome in the Netherlands, Thorax 53: 638-642.
- Bosboom-Van der Hurk P.R., Middelkoop H.A.M., Waalwijk-Van Doorn E.S.C., Roos R.A.C. & Cools H.J.M. (1998), Long-term monitoring of urine leakage in the elderly: an evaluation of the validity and clinical applicability of thermistor signalling, Journal Medical Engineering and Technology 22: 91-93.
- Hilten J.J. van, Eerd A.A. van, Wagemans E.A.H., Middelkoop H.A.M. & Roos R.A.C. (1998), Bradykinesia and hypokinesia in Parkinson's disease: What's in a name?, Journal of Neural Transmission 105: 229-237.
- Roos-Van Eijndhoven D.G., Middelkoop H.A.M. & Cools H.J.M. (1998), Long-term ambulatory monitoring of bladder temperature in older people: a pilot study, Journal of the American Geriatrics Society 46(12): 1583-1584.
- Knuistingh Neven A., Middelkoop H.A.M., Kemp B. & Springer M.P. (1998), The prevalence of clinically significant sleep apnoea syndrome in the Netherlands, Thorax 53: 638-642.
- Bosboom-Van der Hurk P.R., Middelkoop H.A.M., Waalwijk-Van Doorn E.S.C., Roos R.A.C. & Cools H.J.M. (1998), Long-term ambulatory monitoring of urine leakage in the elderly: an evaluation of the validity and clinical applicability of thermistor signalling, Journal Medical Engineering and Technology 22: 91-93.
- Knuistingh Neven A., Middelkoop H.A.M., Kemp B., Kamphuisen H.A.C. & Springer M.P. (1997), The diagnostic work-up of the sleep apnoea syndrome. In: Beersma D.G.M., Kamphuisen H.A.C., Arends J.B.A.M. & Bemmel A.L. (Eds.), Sleep-Wake Research in The Netherlands. Leiden.
- Knuistingh Neven A., Middelkoop H.A.M., Kemp B., Kamphuisen H.A.C. & Springer M.P. (1997), The diagnostic work-up of the sleep apnoea syndrome: the realtionship between the apnoea index obtained by home thermistry and the apnoea index obtained by all night polysomnography. In: Beersma D.G.M., Arends J.B.A.M., Bemmel A.L. van, Hofman W.F. & Ruigt G.S.F. (Eds.), Sleep-wake research in the Netherlands.. Utrecht: Elinkwijk. 71-74.
- Middelkoop H.A.M., Gils K. van & Kooij S. (1997), Adult attention-deficit hyperactivity disorder (ADHD): actimetric evaluation of nocturnal motor activity and subjective sleep characteristics. In: Beersma D.G.M., Arends J.B.A.M., Bemmel A.L., Hofman W.F. & Ruigt G.S.F. (Eds.), Sleep-wake research in the Netherlands.. Utrecht: Einkwijk. 87-90.
- Lammers G.J., Middelkoop H.A.M., Smilde-Van den Doel D.A., Mourtazaev M. & Dijk J.G. van (1997), Sleep scoring at a lower resolution, Journal of Sleep Research 20: 641-644.
- Middelkoop H.A.M. & Sadeh A. (1997), De rol en waarde van actimetrie bij de evaluatie van slaap-waak en gerelateerde stoornissen, Tijdschrift voor Psychiatrie 39: 256-2652.
- Roon K.I. & Middelkoop H.A.M. (1997), Radiologisch en (neuro-)psychologisch migraine onderzoek, Migraine onderzoek in Nederland 5: 6-6.
- Hoff J.I., Hilten J.J. van, Middelkoop H.A.M. & Roos R.A.C. (1997), Fatique in Parkinson's disease is not associated with reduces physical activity, Parkinsonism & Related Disorders 3: 51-54.
- Middelkoop H.A.M., Dam E.M., Smilde D.A. & Dijk J.G. van (1997), 45-Hour quintuple actimetry relations between trunk and limb movements and effects of circadian sleep-wake rhythmicity, Psychophysiology 34: 199-203.
- klinisch neuropsycholoog en GZ-psycholoog