Hanno Pijl
Professor
- Name
- Prof. dr. H. Pijl
- Telephone
- 071 5263571
- h.pijl@lumc.nl
- ORCID iD
- 0000-0002-3076-1551
I am an internist-endocrinologist in the Department of Internal Medicine and Professor of Diabetology, in particular the neuro-endocrine regulation of diabetes and overweight. I am board member of the biomedical research profile “Aging”. I have been a member of the Dutch Health Council (standing committee on Nutrition) from 2008-2017 and chairman of the Dutch Partnership of Professionals involved in the treatment of overweight from 2014-2017. I am a member of the Societal Advisory board of Diagnosis Nutrition and Health, a public-private consortium which initiates, facilitates and accelerates projects in the area of nutrition and health.
More information about Hanno Pijl
I am an internist-endocrinologist in the Department of Internal Medicine and Professor of Diabetology, in particular the neuro-endocrine regulation of diabetes and overweight.
I am board member of the biomedical research profile “Aging”. I have been a member of the Dutch Health Council (standing committee on Nutrition) from 2008-2017 and chairman of the Dutch Partnership of Professionals involved in the treatment of overweight from 2014-2017. I am a member of the Societal Advisory board of Diagnosis Nutrition and Health, a public-private consortium which initiates, facilitates and accelerates projects in the area of nutrition and health. I am a member of the board of the Dutch Society for Research on Aging and Advisory board member of the Association for Medical doctors and Nutrition. I am one of the two scientific coordinators of a joint TNO-LUMC Innovation Center for Lifestyle Medicine.
Type 2 diabetes and lifestyle medicine
Type 2 diabetes is caused by interaction between our genetic architecture and our lifestyle and environment. The same holds true for many of the major non-communicable chronic diseases. The Dutch National Research Agenda acknowledges the importance of this interaction and stimulates research into the effects of lifestyle on health and disease. I aim to address this broad-based societal demand for knowledge and implementation of this particular issue. My primary focus is prevention and treatment of type 2 diabetes by lifestyle medicine. However, other chronic diseases have my attention in this context as well. My research is part of the research line “Metabolic Health: pathophysiological trajectories and therapy (20102), which is an integral component of the Biomedical Research Profile Vascular and Regenerative Medicine.
Academic career
I defended my thesis, entitled “Serotonin and food selection; studies in obese and bulimic humans” in 1994. I was appointed professor of Diabetology in 2007. I made my inaugural speech, entitled 'In het land van bitterbal en boterkoek' (In the land of 'bitterbal' and butter cake) in 2008.
Prizes and honourable appointments
I have been selected (with honours) as senior member of Food100 2017, the one hundred most prominent “gamechangers” in the area of nutrition and health in the Netherlands in 2017.
Professor
- Faculty of Medicine
- LUMC
Contact
- Embgenbroich, M.; Zande, H.J.P. van der; Hussaarts, L.; Schulte-Schrepping, J.; Pelgrom, L.R.; Garcia-Tardon, N.; Schlautmann, L.; Stoetzel, I.; Handler, K.; Lambooij, J.M.; Zawistowska-Deniziak, A.; Hoving, L.; Ruiter, K. de; Wijngaarden, M.; Pijl, H.; Dijk, K.W. van; Everts, B.; Harmelen, V. van; Yazdanbakhsh, M.; Schultze, J.L.; Guigas, B. & Burgdorf, S. (2021), Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation, Proceedings of the National Academy of Sciences 118(31).
- Snel, M.; Jonker, J.T.; Schoones, J.; Lamb, H.; Roos, A. de; Pijl, H.; Smit, J.W.A.; Meinders, A.E. & Jazet, I.M. (2012), Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions, INTERNATIONAL JOURNAL OF ENDOCRINOLOGY: -.
- Kokkorakis, M.; Folkertsma, P.; Anagnostakis, F.; Sirotin, N.; Agarwal, M.; Shantouf, R.; Henning, R.H.; Pijl, H.; Wolffenbuttel, B.H.R.; Bax, J.J.; Atsma, D.E.; Forte, J.C.; Mantzoros, C.S. & Dam, S. van (2025), Simplifying coronary artery disease risk stratification, EBioMedicine 111.
- Burg, E.L. van den; Schoonakker, M.P.; Peet, P.G. van; Numans, M.E.; Pijl, H. & Lamb, H.J. (2024), A fasting-mimicking diet programme reduces liver fat and inflammation/fibrosis measured by MRI-derived biomarkers in patients with type 2 diabetes, Diabetologia 67: S16-S17.
- Jacobs, A.; Nijland, L.M.G.; Steenhuis, I.H.M.; Veen, R.N. van; Liem, R.S.L.; Pijl, H.; Beek, L. ter; Tollenaar, R.A.E.M. & Monpellier, V.M. (2024), Food and health literacy in patients awaiting metabolic-bariatric surgery, Obesity Facts: The European Journal of Obesity 18(1).
- Snel, T.; Krone, T.; Kamstra, R.J.M.; Eggink, H.M.; Pijl, H.; Graaf, A.A. de & Hoogh, I.M. de (2024), Differential impact of lifestyle factors on 2-hour glucose values in individuals with type 2 diabetes, BMJ Open Diabetes Research & Care 12(6).
- Schoonakker, M.P.; Peet, P.G. van; Burg, E.L. van den; Numans, M.E.; Ducarmon, Q.R.; Pijl, H. & Wiese, M. (2024), Impact of dietary carbohydrate, fat or protein restriction on the human gut microbiome, Nutrition Research Reviews.
- Burg, E.L. van den; Schoonakker, M.P.; Peet, P.G. van; Marle, E.M.V.; Lamb, H.J.; Longo, V.D.; Numans, M.E. & Pijl, H. (2024), Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control, Diabetologia 67.
- Koppold, D.A.; Breinlinger, C.; Hanslian, E.; Kessler, C.; Cramer, H.; Khokhar, A.R.; Peterson, C.M.; Tinsley, G.; Vernieri, C.; Bloomer, R.J.; Boschmann, M.; Bragazzi, N.L.; Brandhorst, S.; Gabel, K.; Goldhamer, A.C.; Grajower, M.M.; Harvie, M.; Heilbronn, L.; Horne, B.D.; Karras, S.N.; Langhorst, J.; Lischka, E.; Madeo, F.; Mitchell, S.J.; Papagiannopoulos-Vatopaidinos, I.E.; Papagiannopoulou, M.; Pijl, H.; Ravussin, E.; Ritzmann-Widderich, M.; Varady, K.; Adamidou, L.; Chihaoui, M.; Cabo, R. de; Hassanein, M.; Lessan, N.; Longo, V.; Manoogian, E.N.C.; Mattson, M.P.; Muhlestein, J.B.; Panda, S.; Papadopoulou, S.K.; Rodopaios, N.E.; Stange, R. & Michalsen, A. (2024), International consensus on fasting terminology, Cell Metabolism 36(8).
- Gannamani, R.; Forte, J.C.; Folkertsma, P.; Hermans, S.; Kumaraswamy, S.; Dam, S. van; Chavannes, N.; Os, H. van; Pijl, H. & Wolffenbuttel, B.H.R. (2024), A digitally enabled combined lifestyle intervention for weight loss, JMIR Formative Research 8.
- Burg, E.L. van den; Schoonakker, M.P.; Korpershoek, B.; Sommeling, L.E.; Sturm, C.A.; Lamb, H.J.; Pijl, H.; Numans, M.E.; Adriaanse, M.A. & Peet, P.G. van (2024), Self-initiated lifestyle changes during a fasting-mimicking diet programme in patients with type 2 diabetes, BMC Primary Care 25(1).
- Donjacour, C.E.H.M.; Gool, J.K.; Schoffelen, P.F.; Wouters, L.; Overeem, S.; Lammers, G.J.; Pijl, H. & Westerterp, K.R. (2024), Measuring energy expenditure in narcolepsy using doubly labeled water and respiration chamber calorimetry, SLEEP 48.
- Spoel, E. van der; Cornet, S.; Zutinic, A.; Ballieux, B.; Slagboom, P.E.; Pijl, H. & Heemst, D. van (2024), Effect of thyroid status modulation on pituitary and peripheral hormone concentrations in healthy older subjects, Neuroendocrinology 115(1).
- Frel, D.L. de; Schroijen, M.A.; Aardoom, J.J.; Gils, W. van; Huisman, S.; Janssen, V.R.; Versluis, A.; Kleinsmann, M.S.; Atsma, D.E. & Pijl, H. (2024), Participatory development of an integrated, eHealth-supported, educational care pathway (Diabetes Box) for people with type 2 diabetes, JMIR Human Factors 11.
- Velden, A.I.M. van der; Ijpelaar, D.H.T.; Shaw, P.K.C.; Pijl, H.; Vink, H.; Vlag, J. van der; Rabelink, T.J. & Berg, B.M. van den (2024), Role of dietary interventions on microvascular health in South-Asian Surinamese people with type 2 diabetes in the Netherlands, Nutrition and Diabetes 14(1).
- I.M. de Hoogh; Tim Snel; Regina J.M. Kamstra; Tanja Krone; Albert A. de Graaf; H. Pijl. (2024), Differential effects of lifestyle interventions on continuous glucose monitoring metrics in persons with type 2 diabetes: potential for personalized treatment, Nutrition and Metabolism.
- Skvortsova A., Veldhuijzen D.S., Dillen L.F. van, Zech H.G., Derksen S.M.J.C., Sars R.H., Meijer O.C., Pijl H. & Evers A.W.M. (2023), Influencing the insulin system by placebo effects in patients with diabetes type 2 and healthy controls: a randomized controlled trial, Psychosomatic Medicine 85(6): 551-560.
- Schacky, C. von; Kuipers, R.S.; Pijl, H.; Muskiet, F.A.J. & Grobbee, D.E. (2023), Omega-3 fatty acids in heart disease, Netherlands Heart Journal.
- Hoogh, I.M. de; Snel, T.; Kamstra, R.J.M.; Krone, T.; Eggink, H.E.; Pijl, H. & Graaf, A.A. de (2023), The influence of lifestyle interventions on continuously measured glucose levels in people with type 2 diabetes: an N-of-1 analysis, Annals of Nutrition and Metabolism 79: 334-335.
- Gruil, N. de; Böhringer, S.; Groot, S. de; Pijl, H.; Kroep, J.R. & Swen, J.J. (2023), IGF1 and insulin receptor single nucleotide variants associated with response in HER2-negative breast cancer patients treated with neoadjuvant chemotherapy with or without a fasting mimicking diet (BOOG 2013-04 DIRECT trial), Cancers 15(24).
- Snel, T.; Hoogh, I. de; Kamstra, K.; Krone, T.; Eggink, H.; Graaf, A. de & Pijl, H. (2023), PREDICTING THE EFFECTS OF LIFESTYLE ON CONTINUOUSLY MEASURED GLUCOSE LEVELS IN INDIVIDUALS WITH TYPE 2 DIABETES USING MULTILEVEL MODELING, Diabetes Technology & Therapeutics 25: A101-A101.
- Gruil, N. de; Welters, M.J.P.; Kaart, S.; Pijl, H.; Burg, S.H. van der & Kroep, J.R. (2023), Find: Immunomodulation after a fasting mimicking diet analyzed by Nanostring and multispectral flowcytometry in healthy volunteers: A pilot study., Journal of Clinical Oncology 41(16).
- Gruil, N. de; Liefers, G.J.; Schagen, S.B.; Meershoek, E.; Veen-Lievaart, M.E.; Hinnen, C.; Putter, H.; Heijns, J.B.; Goosens, A.; Tol, J.; Baars, A.; Veldhuis, G.J.; Kessels, L.W.; Wouw, A.J. van de; Vulink, A.J.E.; Toonen, F.A.J.; Huinink, D.T.B.; Burg, S.H. van der; Pijl, H. & Kroep, J.R. (2023), DIRECT2: A randomized phase III trial with a fasting mimicking diet program to improve chemotherapy in patients with hormone receptor positive, HER2-negative breast cancer-A Dutch Breast Cancer Research Group study (BOOG), Journal of Clinical Oncology 41(16).
- Burg, E.L. van den; Peet, P.G. van; Schoonakker, M.P.; Haar, D.E. van de; Numans, M.E. & Pijl, H. (2023), Metabolic impact of intermittent energy restriction and periodic fasting in patients with type 2 diabetes, Nutrition Reviews.
- Skvortsova, A.; Veldhuijzen, D.S.; Dillen, L.F. van; Zech, H.; Derksen, S.M.J.C.; Sars, R.H.; Meijer, O.C.; Pijl, H. & Evers, A.W.M. (2023), Influencing the insulin system by placebo effects in patients with diabetes type 2 and healthy controls, Psychosomatic Medicine: Journal of Biobehavioral Medicine 85(6): 551-560.
- Lugtenberg, R.T.; Groot, S. de; Houtsma, D.; Dezentje, V.O.; Vulink, A.J.E.; Fischer, M.J.; Portielje, J.E.A.; Hoeven, J.J.M. van der; Gelderblom, H.; Pijl, H. & Kroep, J.R. (2023), Phase 1 study to evaluate the safety of reducing the prophylactic dose of dexamethasone around docetaxel infusion in patients with prostate and breast cancer, Cancers 15(6).
- Gruil, N. de; Pijl, H.; Burg, S.H. van der & Kroep, J.R. (2022), Short-term fasting synergizes with solid cancer therapy by boosting antitumor immunity, Cancers 14(6).
- Simons, L.P.A.; Pijl, H.; Verhoef, J.; Lamb, H.J.; Ommen, B. van; Gerritsen, B.; Bizino, M.B.; Snel, M.; Feenstra, R. & Jonker, C.M. (2022), E-health relationships diabetes, International Journal of Biomedical Engineering and Technology 38(1): 81-98.
- Hagenaars, S.C.; Groot, S. de; Cohen, D.; Dekker, T.J.A.; Charehbili, A.; Kranenbarg, E.M.K.; Carpentier, M.D.D.; Pijl, H.; Putter, H.; Tollenaar, R.A.E.M.; Kroep, J.R.; Mesker, W.E. & Dutch Breast Can (2021), Tumor-stroma ratio is associated with Miller-Payne score and pathological response to neoadjuvant chemotherapy in HER2-negative early breast cancer, International Journal of Cancer 149(5).
- (2021), Familial longevity is associated with lower baseline bone turnover but not differences in bone turnover in response to rhTSH, Aging.
- Ruissen, M.M.; Regeer, H.; Landstra, C.P.; Schroijen, M.; Jazet, I.; Nijhoff, M.F.; Pijl, H.; Ballieux, B.E.P.B.; Dekkers, O.; Huisman, S.D. & Koning, E.J.P. de (2021), Increased stress, weight gain and less exercise in relation to glycemic control in people with type 1 and type 2 diabetes during the COVID-19 pandemic, BMJ Open Diabetes Research and Care 9(1).
- Pot, G.K.; Jong, H.B.T.; Battjes-Fries, M.C.E.; Patijn, O.N.; Pijl, H. & Voshol, P.J. (2021), Observational study on dietary changes of participants following a multicomponent lifestyle program (Reverse Diabetes2 Now), Journal of Human Nutrition and Dietetics.
- Zutinic, A.; Roelfsema, F.; Pijl, H.; Ballieux, B.E.; Westendorp, R.G.J.; Blauw, G.J. & Heemst, D. van (2021), Familial longevity is associated with lower baseline bone turnover but not differences in bone turnover in response to rhTSH, Aging 13(17): 21029-21039.
- Hoogh, I.M. de; Oosterman, J.E.; Otten, W.; Krijger, A.M.; Berbee-Zadelaar, S.; Pasman, W.J.; Ommen, B. van; Pijl, H. & Wopereis, S. (2021), The effect of a lifestyle intervention on type 2 diabetes pathophysiology and remission, Nutrients 13(7).
- Van Opstal A.M., Hafkemeijer A., Van den Berg-Huysmans A.A., Hoeksma M., Blonk C., Pijl H., Rombouts S.A.R.B. & Van den Grond J. (2020), Brain activity and connectivity changes in response to glucose ingestion, Nutritional Neuroscience 23(2): 110-117.
- Opstal, A.M. van; Hafkemeijer, A.; Berg-Huysmans, A.A. van den; Hoeksma, M.; Blonk, C.; Pijl, H.; Rombouts, S.A.R.B. & Grond, J. van der (2020), Brain activity and connectivity changes in response to glucose ingestion, Nutritional Neuroscience 23(2): 110-117.
- Hagenaars, S.; Groot, S. de; Cohen, D.; Charehbili, A.; Dekker, T.; Kranenbarg, E.M.K.; Duijm-de Carpentier, M.; Pijl, H.; Putter, H.; Tollenaar, R.; Kroep, J. & Mesker, W. (2020), Tumor-stroma ratio is associated with Miller-Payne and pathological response to neoadjuvant chemotherapy in HER2-negative early breast cancer, European Journal of Cancer 138: S106-S106.
- Spoel, E. van der; Roelfsema, F.; Akintola, A.A.; Jansen, S.W.; Slagboom, P.E.; Westendorp, R.G.J.; Blauw, G.J.; Pijl, H. & Heemst, D. van (2020), Interrelationships between pituitary hormones as assessed from 24-hour serum concentrations in healthy older subjects, The Journal of Clinical Endocrinology & Metabolism 105(4).
- Burg, E.L. van den; Schoonakker, M.P.; Peet, P.G. van; Akker-van Marle, M.E. van den; Dijk, K.W. van; Longo, V.D.; Lamb, H.J.; Numans, M.E. & Pijl, H. (2020), Fasting in diabetes treatment (FIT) trial, BMC Endocrine Disorders 20(1).
- Burg, E.L. van den; Schoonakker, M.P.; Peet, P.G. van; Akker-van Marle, M.E. van den; Dijk, K.W. van; Longo, V.D.; Lamb, H.J.; Numans, M.E. & Pijl, H. (2020), Fasting in diabetes treatment (FIT) trial, BMC Endocrine Disorders 20(1).
- Frel, D.L. de; Atsma, D.E.; Pijl, H.; Seidell, J.C.; Leenen, P.J.M.; Dik, W.A. & Rossum, E.F.C. van (2020), The impact of obesity and lifestyle on the immune system and susceptibility to infections such as COVID-19, Frontiers in Nutrition 7.
- Groot, S. de; Rottgering, B.; Gelderblom, H.; Pijl, H.; Szuhai, K. & Kroep, J.R. (2020), Unraveling the resistance of IGF-pathway inhibition in ewing sarcoma, Cancers 12(12).
- Zutinic, A.; Pijl, H.; Ballieux, B.E.; Roelfsema, F.; Westendorp, R.G.J.; Blauw, G.J. & Heemst, D. van (2020), Familial longevity is associated with an attenuated thyroidal response to recombinant human thyroid stimulating hormone, Journal of Clinical Endocrinology and Metabolism 105(7): E2572-E2580.
- Zutinic, A.; Blauw, G.J.; Pijl, H.; Ballieux, B.E.; Westendorp, R.G.J.; Roelfsema, F. & Heemst, D. van (2020), Circulating thyroid hormone profile in response to a triiodothyronine challenge in familial longevity, Journal of the Endocrine Society 4(10).
- Groot, S. de; Lugtenberg, R.T.; Cohen, D.; Welters, M.J.P.; Ehsan, I.; Vreeswijk, M.P.G.; Smit, V.T.H.B.M.; Graaf, H. de; Heijns, J.B.; Portielje, J.E.A.; Wouw, A.J. van de; Imholz, A.L.T.; Kessels, L.W.; Vrijaldenhoven, S.; Baars, A.; Kranenbarg, E.M.K.; Duijm-de Carpentier, M.; Putter, H.; Hoeven, J.J.M. van der; Nortier, J.W.R.; Longo, V.D.; Pijl, H.; Kroep, J.R.; Goker, E.; Pas, A.J.M.; Honkoop, A.H. & Dutch Breast Canc Res Grp BOOG (2020), Fasting mimicking diet as an adjunct toneoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial, Nature Communications 11(1).
- Lugtenberg, R.T.; Groot, S. de; Kaptein, A.A.; Fischer, M.J.; Kranenbarg, E.M.K.; Duijm-de Carpentier, M.; Cohen, D.; Graaf, H. de; Heijns, J.B.; Portielje, J.E.A.; Wouw, A.J. van de; Imholz, A.L.T.; Kessels, L.W.; Vrijaldenhoven, S.; Baars, A.; Fiocco, M.; Hoeven, J.J.M. van der; Gelderblom, H.; Longo, V.D.; Pijl, H.; Kroep, J.R. & Dutch Breast Canc Res Grp BOOG (2020), Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013-14) trial, Breast Cancer Research and Treatment 185.
- Aziz, N.A.; Roos, R.A.C. & Pijl, H. (2020), Insulin sensitivity in De Novo Parkinson's disease, Movement Disorders 35(9).
- Spoel, E. van der; Oei, N.; Cachucho, R.; Roelfsema, F.; Berbee, J.F.P.; Blauw, G.J.; Pijl, H.; Appelman-Dijkstra, N.M. & Heemst, D. van (2019), The 24-hour serum profiles of bone markers in healthy older men and women, BONE 120: 61-69.
- Gardiner, S.L.; Mutsert, R. de; Trompet, S.; Boogaard, M.W.; Dijk, K.W. van; Jukema, P.J.W.; Slagboom, P.E.; Roos, R.A.C.; Pijl, H.; Rosendaal, F.R. & Aziz, N.A. (2019), Repeat length variations in polyglutamine disease-associated genes affect body mass index, International Journal of Obesity 43(3): 440-449.
- Groot, S. de; Pijl, H.; Hoeven, J.J.M. van der & Kroep, J.R. (2019), Effects of short-term fasting on cancer treatment, Journal of Experimental and Clinical Cancer Research 38.
- Opstal, A.M. van; Berg-Huysmans, A.A. van den; Hoeksma, M.; Blonk, C.; Pijl, H.; Rombouts, S.A.R.B. & Grond, J. van der (2019), Effect of flavor on neuronal responses of the hypothalamus and ventral tegmental area, Scientific Reports 9.
- Opstal, A.M. van; Kaal, I.; Berg-Huysmans, A.A. van den; Hoeksma, M.; Blonk, C.; Pijl, H.; Rombouts, S.A.R.B. & Grond, J. van der (2019), Dietary sugars and non-caloric sweeteners elicit different homeostatic and hedonic responses in the brain, Nutrition 60: 80-86.
- Groot, S. de; Lugtenberg, R.T.; Welters, M.J.; Ehsan, I.; Vreeswijk, M.P.; Smit, V.T.; Graaf, H. de; Heijns, J.B.; Portielje, J.E.; Wouw, A.J. van de; Imholz, A.L.; Kessels, L.W.; Vrijaldenhoven, S.; Baars, A.; Kranenbarg, E.M.K.; Duijm-de Carpentier, M.; Leeuwen-Stok, E. van; Putter, H.; Longo, V.D.; Hoeven, J.J. van der; Nortier, J.W.; Pijl, H. & Kroep, J.R. (2019), DIetary REstriction as an adjunct to neoadjuvant ChemoTherapy for HER2-negative breast cancer: Final results from the DIRECT trial (BOOG 2013-04), Cancer Research 79(4).
- Opstal, A.M. van; Hafkemeijer, A.; Berg-Huysmans, A.A. van den; Hoeksma, M.; Mulder, T.P.J.; Pijl, H.; Rombouts, S.A.R.B. & Grond, J. van der (2019), Brain activity and connectivity changes in response to nutritive natural sugars, non-nutritive natural sugar replacements and artificial sweeteners, Nutritional Neuroscience.
- Groot, S. de; Pijl, H.; Charehbili, A.; Ven, S. van de; Smit, V.T.H.B.M.; Meershoek-Klein Kranenbarg, E.; Heijns, J.B.; Warmerdam, L.J.C. van; Kessels, L.W.; Dercksen, M.W.; Pepels, M.J.A.E.; Laarhoven, H.W.M. van; Vriens, B.E.P.J.; Putter, H.; Fiocco, M.; Liefers, G.J.; Hoeven, J.J.M. van der; Nortier, J.W.R.; Kroep, J.R. & Dutch Breast Canc Res Grp (2019), Addition of zoledronic acid to neoadjuvant chemotherapy is not beneficial in patients with HER2-negative stage II/III breast cancer: 5-year survival analysis of the NEOZOTAC trial (BOOG 2010-01), Breast Cancer Research 21(1).
- Guo, J.; Givens, D.I.; Astrup, A.; Bakker, S.J.L.; Goossens, G.H.; Kratz, M.; Marette, A.; Pijl, H. & Soedamah-Muthu, S.S. (2019), The Impact of Dairy Products in the Development of Type 2 Diabetes: Where Does the Evidence Stand in 2019?, Advances in Nutrition 10(6): 1066-1075.
- Ommen, B. van; Wopereis, S.; Empelen, P. van; Keulen, H.M. van; Otten, W.; Kasteleyn, M.; Molema, J.J.W.; Hoogh, I.M. de; Chavannes, N.H.; Numans, M.E.; Evers, A.W.M. & Pijl, H. (2018), From Diabetes Care to Diabetes Cure-The Integration of Systems Biology, eHealth, and Behavioral Change, Frontiers in Endocrinology 8.
- Opstal, A.M. van; Berg-Huysmans, A.A. van den; Hoeksma, M.; Blonk, C.; Pijl, H.; Rombouts, S.A.R.B. & Grond, J. van der (2018), The effect of consumption temperature on the homeostatic and hedonic responses to glucose ingestion in the hypothalamus and the reward system, American Journal of Clinical Nutrition 107(1): 20-25.
- Ozcan, B.; Rutters, F.; Snoek, F.J.; Roosendaal, M.; Sijbrands, E.J.; Elders, P.J.M.; Holleman, F.; Pijl, H.; Tack, C.J.; Abbink, E.J.; Valk, H.W. de; Wolffenbuttel, B.H.R.; Stehouwer, C.D.A.; Schaper, N.C.; Dekker, J.M.; Schram, M.T. & Diabet Peart Parelsnoer Initiative (2018), High Diabetes Distress Among Ethnic Minorities Is Not Explained by Metabolic, Cardiovascular, or Lifestyle Factors: Findings From the Dutch Diabetes Pearl Cohort, Diabetes Care 41(9): 1854-1861.
- Zuuren, E.J. van; Fedorowicz, Z.; Kuijpers, T. & Pijl, H. (2018), Effects of low-carbohydrate- compared with low-fat-diet interventions on metabolic control in people with type 2 diabetes: a systematic review including GRADE assessments, American Journal of Clinical Nutrition 108(2): 300-331.
- Blauw, L.L.; Aziz, N.A.; Tannemaat, M.R.; Blauw, C.A.; Craen, A.J. de; Pijl, H. & Rensen, P.C.N. (2017), Diabetes incidence and glucose intolerance prevalence increase with higher outdoor temperature, BMJ Open Diabetes Research and Care 5(1).
- Berk, K.A.; Yahya, R.; Verhoeven, A.J.M.; Touw, J.; Leijten, F.P.; Rossum, E.F. van; Wester, V.L.; Lips, M.A.; Pijl, H.; Timman, R.; Erhart, G.; Kronenberg, F.; Lennep, J.E.R. van; Sijbrands, E.J.G. & Mulder, M.T. (2017), Effect of diet-induced weight loss on lipoprotein(a) levels in obese individuals with and without type 2 diabetes, Diabetologia 60(6): 989-997.
- Opstal, A.M. van; Akintola, A.A.; Elst, M. van der; Westendorp, R.G.; Pijl, H.; Heemst, D. van & Grond, J. van der (2017), Effects of intranasal insulin application on the hypothalamic BOLD response to glucose ingestion, Scientific Reports 7.
- Berg, R. van den; Noordam, R.; Kooijman, S.; Jansen, S.W.M.; Akintola, A.A.; Slagboom, P.E.; Pijl, H.; Rensen, P.C.N.; Biermasz, N.R. & Heemst, D. van (2017), Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals, Aging Cell 16(2): 237-243.
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- Parlevliet, E.T.; Wang, Y.N.; Geerling, J.J.; Elst, J.P.S.V.D.; Picha, K.; O'Neil, K.; Stojanovic-Susulic, V.; Ort, T.; Havekes, L.M.; Romijn, J.A.; Pijl, H. & Rensen, P.C.N. (2012), GLP-1 Receptor Activation Inhibits VLDL Production and Reverses Hepatic Steatosis by Decreasing Hepatic Lipogenesis in High-Fat-Fed APOE*3-Leiden Mice, PLoS ONE 7(11): -.
- Teeuwisse, W.M.; Widya, R.L.; Paulides, M.; Lamb, H.J.; Smit, J.W.A.; Roos, A. de; Buchem, M.A. van; Pijl, H. & Grond, J. van der (2012), Short-Term Caloric Restriction Normalizes Hypothalamic Neuronal Responsiveness to Glucose Ingestion in Patients With Type 2 Diabetes, Diabetes 61(12): 3255-3259.
- Donjacour, C.; Aziz, A.; Streefland, T.C.; Overeem, S.; Lammers, G. & Pijl, H. (2012), INSULIN SENSITIVITY IN NARCOLEPSY AND THE EFFECT OF SODIUM OXYBATE AS MEASURED BY A HYPERINSULINEMIC-EUGLYCEMIC CLAMP, SLEEP 35: A270-A270.
- Donjacour, C.E.H.M.; Kalsbeek, A.; Overeem, S.; Lammers, G.J.; Pevet, P.; Bothorel, B.; Pijl, H. & Aziz, N.A. (2012), Altered Circadian Rhythm of Melatonin Concentrations in Hypocretin-Deficient Men, Chronobiology International 29(3): 356-362.
- Snel, M.; Gastaldelli, A.; Ouwens, D.M.; Hesselink, M.K.C.; Schaart, G.; Buzzigoli, E.; Frolich, M.; Romijn, J.A.; Pijl, H.; Meinders, A.E. & Jazet, I.M. (2012), Effects of Adding Exercise to a 16-Week Very Low-Calorie Diet in Obese, Insulin-Dependent Type 2 Diabetes Mellitus Patients, Journal of Clinical Endocrinology and Metabolism 97(7): 2512-2520.
- Snel, M.; Jonker, J.T.; Hammer, S.; Kerpershoek, G.; Lamb, H.J.; Meinders, A.E.; Pijl, H.; Roos, A. de; Romijn, J.A.; Smit, J.W.A. & Jazet, I.M. (2012), Long-Term Beneficial Effect of a 16-Week Very Low Calorie Diet on Pericardial Fat in Obese Type 2 Diabetes Mellitus Patients, Obesity 20(8): 1572-1576.
- Wijsman, C.; Heemst, D. van; Slagboom, E.; Pijl, H.; Ouderaa, F. van der; Westendorp, R. & Mooijaart, S. (2012), AMBULANT 24-HOUR GLUCOSE RHYTHMS IN CHRONOLOGICAL AGE AND FAMILIAL LONGEVITY IN INDIVIDUALS WITHOUT DIABETES.
- Bakker, L.E.H.; Guigas, B.; Streefland, T.C.M.; Pijl, H.; Meinders, A.E. & Jazet, I.M. (2012), A 5-day high fat high calorie diet impairs insulin sensitivity in healthy, young, lean male Dutch Surinamese South Asians but not in Dutch Caucasians, Diabetologia 55: S252-S252.
- Wijsman, C.A.; Heemst, D. van; Hoogeveen, E.S.; Slagboom, P.E.; Maier, A.B.; Craen, A.J.M. de; Ouderaa, F. van der; Pijl, H.; Westendorp, R.G.J. & Mooijaart, S.P. (2012), Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals., Aging Cell.
- Vos, R.C.; Huisman, S.D.; Houdijk, E.C.A.M.; Pijl, H. & Wit, J.M. (2012), The effect of family-based multidisciplinary cognitive behavioral treatment on health-related quality of life in childhood obesity, Quality of Life Research 21(9): 1587-1594.
- Donjacour, C.E.H.M.; Aziz, N.A.; Frolich, M.; Roelfsema, F.; Overeem, S.; Lammers, G.J. & Pijl, H. (2011), Sodium oxybate increases prolactin secretion in narcolepsy patients and healthy controls, European Journal of Endocrinology 164(3): 363-370.
- Martinelli, C.E.; Keogh, J.M.; Greenfield, J.R.; Henning, E.; Klaauw, A.A. van der; Blackwood, A.; O'Rahilly, S.; Roelfsema, F.; Camacho-Hubner, C.; Pijl, H. & Farooqi, I.S. (2011), Obesity due to Melanocortin 4 Receptor (MC4R) Deficiency Is Associated with Increased Linear Growth and Final Height, Fasting Hyperinsulinemia, and Incompletely Suppressed Growth Hormone Secretion, Journal of Clinical Endocrinology and Metabolism 96(1): E181-E188.
- Pijl, H. (2011), Obesity: evolution of a symptom of affluence. How food has shaped our existence.
- Donjacour, C.E.H.M.; Aziz, N.A.; Roelfsema, F.; Frolich, M.; Overeem, S.; Lammers, G.J. & Pijl, H. (2011), Effect of sodium oxybate on growth hormone secretion in narcolepsy patients and healthy controls, AJP - Endocrinology and Metabolism 300(6): E1069-E1075.
- Aarts, E.; Lips, M.; Wijngaarden, M.; Groot, G. de; Janssen, I.; Berends, F.; Ramshorst, B. van; Wagensveld, B. van; Swank, D.; Dielen, F. van & Pijl, H. (2011), Differential Effects of Gastric Bypass and Banding on Postprandial Glucose and Insulin Secretion in Diabetes and Healthy Obese, Obesity Surgery 21(8): 982-982.
- Weenen, J.E.D. van; Auvinen, H.E.; Parlevliet, E.T.; Coomans, C.P.; Schroder-van der Elst, J.P.; Meijer, O.C. & Pijl, H. (2011), Blocking Dopamine D-2 Receptors by Haloperidol Curtails the Beneficial Impact of Calorie Restriction on the Metabolic Phenotype of High-Fat Diet Induced Obese Mice, Journal of Neuroendocrinology 23(2): 158-167.
- Roelfsema, F.; Kok, P.; Velauis, J.D. & Pijl, H. (2011), Altered multihormone synchrony in obese patients with polycystic ovary syndrome.
- Wijsman, C.A.; Rozing, M.P.; Streefland, T.C.M.; Cessie, S. le; Mooijaart, S.P.; Slagboom, P.E.; Westendorp, R.G.J.; Pijl, H.; Heemst, D. van & Leiden Longevity Study Grp (2011), Familial longevity is marked by enhanced insulin sensitivity., Aging Cell 10(1): 114-21.
- Vos, R.C.; Wit, J.M.; Pijl, H. & Houdijk, E.C.A.M. (2011), Long-term effect of lifestyle intervention on adiposity, metabolic parameters, inflammation and physical fitness in obese children: a randomized controlled trial, Nutrition and Diabetes 1: -.
- Wang, Y.; Parlevliet, E.T.; Geerling, J.J.; Schroder-Van der Elst, J.P.; Smit, J.W.A.; Havekes, L.M.; Romijn, J.A.; Pijl, H. & Rensen, P.C.N. (2011), THE GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST EXENDIN-4 INHIBITS VLDL BIOSYNTHESIS AND SECRETION IN APOE*3-LEIDEN MICE, Atherosclerosis. Supplements 12(1): 2-2.
- Aziz, N.A.; Pijl, H. & Roos, R.A.C. (2011), Weight Loss and Exercise in Obese Older Adults, New England Journal of Medicine 364(25): 2467-2467.
- Wang, Y.A.; Snel, M.; Jonker, J.T.; Hammer, S.; Lamb, H.J.; Roos, A. de; Meinders, A.E.; Pijl, H.; Romijn, J.A.; Smit, J.W.A.; Jazet, I.M. & Rensen, P.C.N. (2011), Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Plasma CETP and Increases Apolipoprotein AI Levels Without Improving the Cholesterol Efflux Properties of HDL, Diabetes Care 34(12): 2576-2580.
- Vos, R.C.; Wit, J.M.; Pijl, H.; Kruyff, C.C. & Houdijk, E.C.A.M. (2011), The effect of family-based multidisciplinary cognitive behavioral treatment in children with obesity: study protocol for a randomized controlled trial, Trials 12: -.
- Vos, R.C.; Houdijk, E.C.A.M.; Kamp, H.J. van der; Pijl, H. & Wit, J.M. (2011), The Predictive Value of the Individual Components of the Metabolic Syndrome for Insulin Resistance in Obese Children, Hormone Research in Paediatrics 76(3): 156-164.
- Donjacour, C.E.; Aziz, N.A.; Roelfsema, F.; Frolich, M.; Overeem, S.; Lammers, G.J. & Pijl, H. (2011), Efficiency of autoregulatory homeostatic responses to imposed caloric excess in lean men (vol 294, pg E808, 2008), AJP - Endocrinology and Metabolism 301(2): E426-E426.
- Aziz, N.A.; Pijl, H.; Frolich, M.; Roelfsema, F. & Roos, R.A.C. (2011), Diurnal Secretion Profiles of Growth Hormone, Thyrotrophin and Prolactin in Parkinson's Disease, Journal of Neuroendocrinology 23(6): 519-524.
- Aziz, N.A.; Pijl, H.; Frolich, M.; Roelfsema, F. & Roos, R.A.C. (2011), Leptin, Adiponectin, and Resistin Secretion and Diurnal Rhythmicity are Unaltered in Parkinson's Disease.
- Coomans, C.P.; Geerling, J.J.; Guigas, B.; Hoek, A.M. van den; Parlevliet, E.T.; Ouwens, D.M.; Pijl, H.; Voshol, P.J.; Rensen, P.C.N.; Havekes, L.M. & Romijn, J.A. (2011), Circulating insulin stimulates fatty acid retention in white adipose tissue via K-ATP channel activation in the central nervous system only in insulin-sensitive mice, Journal of Lipid Research 52(9): 1712-1722.
- Weenen, J.E.D. van; Parlevliet, E.T.; Schroder-van der Elst, J.P.; Berg, S.A. van den; Dijk, K.W. van; Romijn, J.A. & Pijl, H. (2011), Pharmacological Modulation of Dopamine Receptor D2-Mediated Transmission Alters the Metabolic Phenotype of Diet Induced Obese and Diet Resistant C57Bl6 Mice, Experimental Diabetes Research: -.
- Snel, M.; Diepen, J.A. van; Stijnen, T.; Pijl, H.; Romijn, J.A.; Meinders, A.E.; Voshol, P. & Jazet, I.M. (2011), Immediate and long-term effects of addition of exercise to a 16-week very low calorie diet on low-grade inflammation in obese, insulin-dependent type 2 diabetic patients.
- Vis D.J., Westerhuis J.A., Hoefsloot H.C., Pijl H., Roelfsema F., Greef J. van der & Smilde A.K. (2010), Endocrine pulse identification using penalized methods and a minimum set of assumptions, AJP - Endocrinology and Metabolism 298(2): E146-515.
- Roelfsema, F.; Kok, P.; Pereira, A.M. & Pijl, H. (2010), Body Surface Area Determines the Cortisol Production Rate in Obese Patients with Polycystic Ovary Syndrome and Obese Healthy Women., Endocrine Reviews 31(3): -.
- Vis, D.J.; Westerhuis, J.A.; Hoefsloot, H.C.J.; Pijl, H.; Roelfsema, F.; Greef, J. van der & Smilde, A.K. (2010), Endocrine pulse identification using penalized methods and a minimum set of assumptions, AJP - Endocrinology and Metabolism 298(2): E146E155.
- Vidarsdottir, S.; Weenen, J.E.D. van; Frolich, M.; Roelfsema, F.; Romijn, J.A. & Pijl, H. (2010), Effects of Olanzapine and Haloperidol on the Metabolic Status of Healthy Men, Journal of Clinical Endocrinology and Metabolism 95(1): 118-125.
- Snel, M.; Sleddering, M.A.; Pijl, H.; Nieuwenhuizen, W.F.; Frolich, M.; Havekes, L.M.; Romijn, J.A. & Jazet, I.M. (2010), The effect of dietary phytosphingosine on cholesterol levels and insulin sensitivity in subjects with the metabolic syndrome, European Journal of Clinical Nutrition 64(4): 419-423.
- Brouwer, B.G.; Visseren, F.L.J.; Algra, A.; Bockel, J.H. van; Bollen, E.L.E.M.; Doevendans, P.A.; Greving, J.P.; Kappelle, L.J.; Moll, F.L.; Pijl, H.; Romijn, J.A.; Wall, E.E. van der & Graaf, Y. van der (2010), Effectiveness of a hospital-based vascular screening programme (SMART) for risk factor management in patients with established vascular disease or type 2 diabetes: a parallel-group comparative study, Journal of Internal Medicine 268(1): 83-93.
- Aziz, N.A.; Pijl, H.; Frolich, M.; Schroder-van der Elst, J.P.; Bent, C. van der; Roelfsema, F. & Roos, R.A.C. (2010), Growth hormone and ghrelin secretion are associated with clinical severity in Huntington's disease, European Journal of Neurology 17(2): 280-288.
- Weenen, J.E.D. van; Parlevliet, E.T.; Maechler, P.; Havekes, L.M.; Romijn, J.A.; Ouwens, D.M.; Pijl, H. & Guigas, B. (2010), The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha 2-adrenergic receptors in beta cells, Biochemical Pharmacology 79(12): 1827-1836.
- Aziz, N.A.; Pijl, H.; Frolich, M.; Roelfsema, F. & Roos, R.A.C. (2010), Altered thyrotropic and lactotropic axes regulation in Huntington's disease, Clinical Endocrinology 73(4): 540-545.
- Aziz, N.A.; Pijl, H.; Frolich, M.; Graaf, W.M. van der; Roelfsema, F. & Roos, R.A.C. (2010), Leptin secretion rate increases with higher CAG repeat number in Huntington's disease patients, Clinical Endocrinology 73(2): 206-211.
- Aziz, N.A.; Pijl, H.; Frolich, M.; Snel, M.; Streefland, T.C.M.; Roelfsema, F. & Roos, R.A.C. (2010), Systemic energy homeostasis in Huntington's disease patients, Journal of Neurology, Neurosurgery and Psychiatry 81(11): 1233-1237.
- Wijngaarden, M.A.; Snel, M.; Bizino, M.B.; Grond, J. van der; Jazet, I.M.; Romijn, J.A.; Teeuwisse, W.M. & Pijl, H. (2010), Visual and Odorous Food Cues Do Not Modulate the Hypothalamic Response to Fasting in Healthy Humans., Endocrine Reviews 31(3).
- Wijngaarden, M.A.; Buchem, M.A. van; Grond, J. van der; Dijk, K.W. van & Pijl, H. (2010), Hypercaloric High Fat Fast Food Feeding for 5 Days Does Not Affect Oral Glucose Tolerance or Gut Hormone Levels in Healthy Young Men., Endocrine Reviews 31(3).
- Donjacour, C.; Pardi, D.; Aziz, A.; Overeem, S.; Pijl, H. & Lammers, G. (2010), NORMAL 24 HOUR GHRELIN LEVELS IN HUMAN NARCOLEPSY AND IN RESPONSE TO SODIUM OXYBATE, SLEEP 33: A269-A269.
- Vis, D.J.; Westerhuis, J.A.; Hoefsloot, H.C.; Pijl, H.; Roelfsema, F.; Greef, J. van der & Smilde, A.K. (2010), Endocrine pulse identification using penalized methods and a minimum set of assumptions. (vol 298, pg E146, 2010), AJP - Endocrinology and Metabolism 298(4): E894-E894.
- Jonker, J.T.; Snel, M.; Hammer, S.; Kerpershoek, G.; Lamb, H.J.; Meinders, A.E.; Pijl, H.; Roos, A. de; Romijn, J.A.; Smit, J.W.A. & Jazet, I.M. (2010), Diet-Dependent and Tissue-Specific Dynamics in (Non)Adipose Triglyceride Stores in DM2 Patients, Diabetes 59: A486-A486.
- Vidarsdottir, S.; Roelfsema, F.; Streefland, T.; Holst, J.J.; Rehfeld, J.F. & Pijl, H. (2010), Short-term treatment with olanzapine does not modulate gut hormone secretion: olanzapine disintegrating versus standard tablets, European Journal of Endocrinology 162(1): 75-83.
- Vidarsdottir, S.; Vlug, P.; Roelfsema, F.; Frolich, M. & Pijl, H. (2010), Orally Disintegrating and Oral Standard Olanzapine Tablets Similarly Elevate the Homeostasis Model Assessment of Insulin Resistance Index and Plasma Triglyceride Levels in 12 Healthy Men: A Randomized Crossover Study, Journal of Clinical Psychiatry 71(9): 1205-1211.
- Parlevliet, E.T.; Weenen, J.E.D. van; Romijn, J.A. & Pijl, H. (2010), GLP-1 treatment reduces endogenous insulin resistance via activation of central GLP-1 receptors in mice fed a high-fat diet, AJP - Endocrinology and Metabolism 299(2): E318E324.
- Smilde, A.K.; Westerhuis, J.A.; Hoefsloot, H.C.J.; Bijlsma, S.; Rubingh, C.M.; Vis, D.J.; Jellema, R.H.; Pijl, H.; Roelfsema, F. & Greef, J. van der (2010), Dynamic metabolomic data analysis: a tutorial review, Metabolomics 6(1): 3-17.
- Roelfsema, F.; Kok, P.; Pereira, A.M. & Pijl, H. (2010), Cortisol Production Rate Is Similarly Elevated in Obese Women with or without the Polycystic Ovary Syndrome, Journal of Clinical Endocrinology and Metabolism 95(7): 3318-3324.
- Donjacour C, Hazewinkel A, Cessie SL, Overeem S, Lammers G & Pijl H (2009), SLEEP DURATION AND QUALITY IN TYPE 2 DIABETES MELLITUS, SLEEP 32: A145A146.
- van Weenen JED, Parlevliet ET, Ouwens M, Maechler P, Romijn JA, Pijl H & Guigas B (2009), Bromocriptine acutely decreases glucose-stimulated insulin secretion in mice, Diabetologia 52: S229S229.
- Vidarsdottir S, Roelfsema F, Frolich M & Pijl H (2009), Olanzapine shifts the temporal relationship between the daily acrophase of serum prolactin and cortisol concentrations rhythm in healthy men, Psychoneuroendocrinology 34(5): 705-712.
- Pijl H (2009), Neuroendocrine control of glucose and lipid metabolism, Experimental and Clinical Endocrinology and Diabetes 117(10): 655-655.
- Roelfsema F, Kok P, Frolich M, Pereira AM & Pijl H (2009), Disordered and Increased Adrenocorticotropin Secretion with Diminished Adrenocorticotropin Potency in Obese in Premenopausal Women, Journal of Clinical Endocrinology and Metabolism 94(8): 2991-2997.
- Kok P, Roelfsema F, Frolich M, van Pelt J, Meinders AE & Pijl H (2009), Bromocriptine Reduces Augmented Thyrotropin Secretion in Obese Premenopausal Women, Journal of Clinical Endocrinology and Metabolism 94(4): 1176-1181.
- Romijn JA & Pijl H (2009), The muscle-liver axis: does aerobic fitness induce intrahepatic protection against non-alcoholic fatty liver disease?, Journal of Physiology 587(8): 1637-1637.
- Aziz NA, Roelfsema F, Frolich M, Roos RAC & Pijl H (2009), A strategy for finding the optimal deconvolution estimates for hormone secretory kinetics using AutoDecon, Analytical Biochemistry 391(1): 69-71.
- Aziz NA, Pijl H, Frolich M, Schroder-van der Elst JP, van der Bent C, Roelfsema F & Roos RAC (2009), Delayed onset of the diurnal melatonin rise in patients with Huntington's disease, Journal of Neurology 256(12): 1961-1965.
- Aziz NA, Pijl H, Frolich M, van der Graaf AWM, Roelfsema F & Roos RAC (2009), Increased Hypothalamic-Pituitary-Adrenal Axis Activity in Huntington's Disease, Journal of Clinical Endocrinology and Metabolism 94(4): 1223-1228.
- Guigas B, Coomans CP, Geerling JJ, van den Hoek AM, Parlevliet ET, Ouwens DM, Pijl H, Voshol PJ, Rensen PCN, Havekes LM & Romijn JA (2009), Insulin promotes fatty acid storage in white adipose tissue by a CNS-mediated and CD36-dependent mechanism, Diabetologia 52: S265S265.
- Vos, R.; Houdijk, M.; Pijl, H. & Wit, J.M. (2009), The significant improvement on physical fitness and (central) obesity after multidisciplinary treatment in children with obesity is maintained at 1 year follow-up, Hormone Research 72: 414-415.
- Snoep JD, Hovens MMC, Pasha SM, Frolich M, Pijl H, Tamsma JT & Huisman MV (2009), Time-Dependent Effects of Low-Dose Aspirin on Plasma Renin Activity, Aldosterone, Cortisol, and Catecholamines, Hypertension 54(5): 1136-1142.
- Jazet IM, Snel M, Gastaldelli A, Frolich M, Ferrannini E, Romijn JA, Pijl H, Ouwens DM & Meinders AE (2009), Adding exercise to a 16-week very low calorie diet increases skeletal muscle mitochondrial copy number and peak oxygen consumption in obese, insulin-treated type 2 diabetic patients, Diabetologia 52: S99S100.
- van Weenen JED, Hu L, Jansen-Van Zelm K, de Vries MG, Tamsma JT, Romijn JA & Pijl H (2009), Four weeks high fat feeding induces insulin resistance without affecting dopamine release or gene expression patterns in the hypothalamus of C57Bl6 mice, Brain Research 1250: 141-148.
- Hammer S, Snel M, Lamb HJ, Jazet IM, van der Meer RW, Pijl H, Meinders EA, Romijn JA, de Roos A & Smit JWA (2009), Cardiac Steatosis and Myocardial Dysfunction Reply, Journal of the American College of Cardiology 53(7): 636-637.
- Hammer S, Snel M, Lamb HJ, Jazet IM, van der Meer RW, Pijl H, Meinders EA, Romijn JA, de Roos A & Smit JWA (2009), Caloric Restriction Models Reverse Metabolic Syndrome Reply, Journal of the American College of Cardiology 53(10): 900-900.
- Parlevliet ET, Elst JPSVD, Corssmit EPM, Picha K, O'Neil K, Stojanovic-Susulic V, Ort T, Havekes LM, Romijn JA & Pijl H (2009), CNTO736, a Novel Glucagon-Like Peptide-1 Receptor Agonist, Ameliorates Insulin Resistance and Inhibits Very Low-Density Lipoprotein Production in High-Fat-Fed Mice, Journal of Pharmacology and Experimental Therapeutics 328(1): 240-248.
- Jazet, I.M.; Janssen, I.M.C.; Berends, F.J.; Pijl, H.; Romijn, J.A. & Meinders, A.E. (2009), Bariatrische operatie als therapie voor type 2-diabetes, Nederlands Tijdschrift voor Geneeskunde 153(19): 920-5.
- Aziz NA, Pijl H, Froelich M, Van der Graaf M, Roelfsema F & Roos RAC (2008), Increased activity of the hypothalamic-adrenal axis in early-stage Huntington's disease patients, Journal of Neurology, Neurosurgery and Psychiatry 79.
- Jazet IM, Schaart G, Gastaldelli A, Ferrannini E, Hesselink MK, Schrauwen P, Romijn JA, Maassen JA, Pijl H, Ouwens DM & Meinders AE (2008), Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients, Diabetologia 51(2).
- van der Klaauw AA, Pereira AM, Rabelink TJ, Corssmit EPM, Zonneveld AJ, Pijl H, de Boer HC, Smit JWA, Romijn JA & de Koning EJP (2008), Recombinant human GH replacement increases CD34+cells and improves endothelial function in adults with GH deficiency, European Journal of Endocrinology 159(2).
- Hammer S, Snel M, Lamb HJ, Jazet IM, van der Meer RW, Pijl H, Meinders EA, Romijn JA, de Roos A & Smit JWA (2008), Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function, Journal of the American College of Cardiology 52(12).
- Parlevliet ET, Heijboer AC, Schroder-van der Elst JP, Havekes LM, Romijn JA, Pijl H & Corssmit EPM (2008), Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet, AJP - Endocrinology and Metabolism 294(1).
- Romijn JA, Smit JW & Pijl H (2008), Hypoandrogenism in obese men: pathophysiological implications versus practical consequences, Netherlands Journal of Medicine 66(3).
- van den Hoek AM, Teusink B, Voshol PJ, Havekes LM, Romijn JA & Pijl H (2008), Leptin deficiency Per se dictates body composition and insulin action in ob/ob mice, Journal of Neuroendocrinology 20(1).
- van den Hoek AM, van Heijningen C, der Elst JPSV, Ouwens DM, Havekes LM, Romijn JA, Kalsbeek A & Pijl H (2008), Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation, Diabetes 57(9).
- van der Klaauw AA, Kars M, Biermasz NR, Roelfsema F, Dekkers OM, Corssmit EP, van Aken MO, Havekes B, Pereira AM, Pijl H, Smit JW & Romijn JA (2008), Disease-specific impairments in quality of life during long-term follow-up of patients with different pituitary adenomas, Clinical Endocrinology 69(5).
- Kok P, Roelfsema F, Frolich M, van Pelt J, Meinders AE & Pijl H (2008), Short-term treatment with bromocriptine improves impaired circadian growth hormone secretion in obese premenopausal women, Journal of Clinical Endocrinology and Metabolism 93(9).
- Romijn JA, Corssmit EP, Havekes LM & Pijl H (2008), Gut-brain axis, Current Opinion in Clinical Nutrition and Metabolic Care 11(4).
- Vidarsdottir S, Smeets PAM, Eichelsheim DL, van Osch MJP, Viergever MA, Romijn JA, van der Grond J & Pijl H (2007), Glucose ingestion fails to inhibit hypothalamic neuronal activity in patients with type 2 diabetes, Diabetes 56(10).
- Lindeman JHN, Pijl H, Toet K, Eilers PHC, van Ramshorst B, Buijs MM, van Bockel JH & Kooistra T (2007), Human visceral adipose tissue and the plasminogen activator inhibitor type 1, International Journal of Obesity 31(11).
- Aziz NA, Swaab DF, Pijl H & Roos RAC (2007), Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: Clinical consequences and therapeutic implications, Reviews in the Neurosciences 18(3-4).
- van Petersen AS, van der Pijl HW, Ringers J, Lemkes HH, de Fijter HW & Masclee AAM (2007), Gallstone formation after pancreas and/or kidney transplantation: an analysis of risk factors, Clinical Transplantation 21(5).
- Smeets PAM, Vidarsdottir S, De Graaf C, Stafleu A, Van Osch MJP, Viergever MA, Pijl H & Van der Grond J (2007), Oral glucose intake inhibits hypothalamic neuronal activity more effectively than glucose infusion, AJP - Endocrinology and Metabolism 293(3).
- van den Hoek AM, Heijboer AC, Voshol PJ, Havekes LM, Romijn JA, Corssmit EPM & Pijl H (2007), Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice, AJP - Endocrinology and Metabolism 292(1).
- van der Klaauw AA, Biermasz NR, Feskens EJM, Bos MB, Smit JW, Roelfsema F, Corssmit EPM, Pijl H, Romijn JA & Pereira AM (2007), The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH, European Journal of Endocrinology 156(4).
- Kok P, Roelfsema F, Langendonk JG, de Wit CC, Frolich M, Burggraaf J, Meinders AE & Pijl H (2006), Increased circadian prolactin release is blunted after body weight loss in obese premenopausal women, AJP - Endocrinology and Metabolism 290(2).
- Heijboer AC, van den Hoek AM, Parlevliet ET, Havekes LM, Romijn JA, Pijl H & Corssmit EPM (2006), Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice, Diabetologia 49(4).
- van Rossum CTM, Pijl H, Adan RAH, Hoebee B & Seidell JC (2006), Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults, International Journal of Obesity 30(10).
- Kok P, Roelfsema F, Frolich M, van Pelt J, Stokkel MPM, Meinders AE & Pijl H (2006), Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women, AJP - Endocrinology and Metabolism 291(5).
- Kok P, Roelfsema F, Frolich M, van Pelt J, Meinders AE & Pijl H (2006), Activation of dopamine D2 receptors lowers circadian leptin concentrations in obese women, Journal of Clinical Endocrinology and Metabolism 91(8).
- Langendonk JG, Kok P, Frolich M, Pijl H & Meinders AE (2006), Decrease in visceral fat following diet-induced weight loss in upper body compared to lower body obese premenopausal women, European Journal of Internal Medicine 17(7).
- Heijboer AC, Pijl H, Van den Hoek AM, Havekes LM, Romijn JA & Corssmit EPM (2006), Gut-brain axis: Regulation of glucose metabolism, Journal of Neuroendocrinology 18(12).
- van Aken MO, Pereira AM, Frolich M, Romijn JA, Pijl H, Veldhuis JD & Roelfsema F (2005), Growth hormone secretion in primary adrenal Cushing's syndrome is disorderly and inversely correlated with body mass index, AJP - Endocrinology and Metabolism 288(1).
- Heijboer AC, Voshol PJ, Donga E, van Eden CG, Havekes LM, Romijn JA, Pijl H & Corssmit EPM (2005), High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice, Peptides 26(12).
- Jazet IM, Pijl H, Frolich M, Schoemaker RC & Meinders AE (2005), Factors predicting the blood glucose lowering effect of a 30-day very low calorie diet in obese Type 2 diabetic patients, Diabetic Medicine 22(1).
- Kok P, Roelfsema F, Lich MF, Meinders AE & Pijl H (2005), Spontaneous diurnal thyrotropin secretion is enhanced in proportion to circulating leptin in obese premenopausal women, Journal of Clinical Endocrinology and Metabolism 90(11).
- Buijs MM, de Leeuw PW, Houben AJHM, Kroon AA, Frohlich M, Pijl H & Meinders AE (2005), Renal contribution to increased clearance of exogenous growth hormone in obese hypertensive patients, Journal of Clinical Endocrinology and Metabolism 90(2).
- Kok P, Roelfsema F, Langendonk JG, Frolich M, Burggraaf J, Meinders AE & Pijl H (2005), High circulating thyrotropin levels in obese women are reduced after body weight loss induced by caloric restriction, Journal of Clinical Endocrinology and Metabolism 90(8).
- Kok SW, Roelfsema F, Overeem S, Lammers GJ, Frolich M, Meinders AE & Pijl H (2005), Altered setting of the pituitary-thyroid ensemble in hypocretin-deficient narcoleptic men, AJP - Endocrinology and Metabolism 288(5).
- Jazet IM, Pijl H, Frolich M, Romijn JA & Meinders AE (2005), Two days of a very low calorie diet reduces endogenous glucose production in obese type 2 diabetic patients despite the withdrawal of blood glucose-lowering therapies including insulin, Metabolism 54(6).
- Heijboer AC, van den Hoek AM, Pijl H, Voshol PJ, Havekes LM, Romijn JA & Corssmit EPM (2005), Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice, Diabetologia 48(8).
- Kok SW, Roelfsema F, Overeem S, Lammers GJ, Frolich M, Meinders AE & Pijl H (2004), Pulsatile LH release is diminished, whereas FSH secretion is normal, in hypocretin-deficient narcoleptic men, AJP - Endocrinology and Metabolism 287(4).
- Fogteloo AJ, Pijl H, Roelfsema F, Frolich M & Meinders AE (2004), Impact of meal timing and frequency on the twenty-four-hour leptin rhythm, Hormone Research 62(2).
- Kok P, Roelfsema F, Frolich M, Meinders AE & Pijl H (2004), Prolactin release is enhanced in proportion to excess visceral fat in obese women, Journal of Clinical Endocrinology and Metabolism 89(9).
- Muurling M, van den Hoek AM, Mensink RP, Pijl H, Romijn JA, Havekes LM & Voshol PJ (2004), Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance, Journal of Lipid Research 45(1).
- Buijs MM, Romijn JA, Burggraaf J, de Kam ML, Frolich M, Ackermans MT, Sauerwein HP, Cohen AF, Meinders AE & Pijl H (2004), Glucose homeostasis in abdominal obesity: hepatic hyperresponsiveness to growth hormone action, AJP - Endocrinology and Metabolism 287(1).
- Kok P, Buijs MM, Kok SW, van Ierssel IHAP, Frolich M, Roelfsema F, Voshol PJ, Meinders AE & Pijl H (2004), Acipimox enhances spontaneous growth hormone secretion in obese women, AJP - Regulatory, Integrative and Comparative Physiology 286(4).
- Kok P, Kok SW, Buijs MM, Westenberg JJM, Roelfsema F, Frolich M, Stokkel MPM, Meinders AE & Pijl H (2004), Enhanced circadian ACTH release in obese premenopausal women: reversal by short-term acipimox treatment, AJP - Endocrinology and Metabolism 287(5).
- van Dam EWCM, Roelfsema F, Veldhuis JD, Hogendoorn S, Westenberg J, Helmerhorst FM, Frolich M, Krans HMJ, Meinders AE & Pijl H (2004), Retention of estradiol negative feedback relationship to LH predicts ovulation in response to caloric restriction and weight loss in obese patients with polycystic ovary syndrome, AJP - Endocrinology and Metabolism 286(4).
- Smolders MH, Graniewski-Wijnands HS, Meinders AE, Fogteloo AJ, Pijl H & de Keizer RJW (2004), Exophthalmos in obesity, Ophthalmic Research 36(2).
- van den Hoek AM, Voshol PJ, Karnekamp BN, Buijs RM, Romijn JA, Havekes LM & Pijl H (2004), Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin, Diabetes 53(10).
- van den Hoek AM, Heijboer AC, Corssmit EPM, Voshol PJ, Romijn JA, Havekes LM & Pijl H (2004), PYY3-36 reinforces insulin action on glucose disposal in mice fed a high-fat diet, Diabetes 53(8).
- Overeem S, Kok SW, Lammers GJ, Vein AA, Frolich M, Meinders AE, Roelfsema F & Pijl H (2003), Somatotropic axis in hypocretin-deficient narcoleptic humans: altered circadian distribution of GH-secretory events, AJP - Endocrinology and Metabolism 284(3).
- Buijs MM, Burggraaf J, Wijbrandts C, de Kam ML, Frolich M, Cohen AF, Romijn JA, Sauerwein HP, Meinders AE & Pijl H (2003), Blunted lipolytic response to fasting in abdominally obese women: evidence for involvement of hyposomatotropism, American Journal of Clinical Nutrition 77(3).
- Teusink B, Voshol PJ, Dahlmans VEH, Rensen PCN, Pijl H, Romijn JA & Havekes LM (2003), Contribution of fatty acids released from lipolysis of plasma triglycerides to total plasma fatty acid flux and tissue-specific fatty acid uptake, Diabetes 52(3).
- Pijl H (2003), Reduced dopaminergic tone in hypothalamic neural circuits: expression of a "thrifty" genotype underlying the metabolic syndrome?, European Journal of Pharmacology 480(1-3).
- Muurling M, Mensink RP, Pijl H, Romijn JA, Havekes LM & Voshol PJ (2003), A fish oil diet does not reverse insulin resistance despite decreased adipose tissue TNF-alpha protein concentration in ApoE-3*Leiden mice, Journal of Nutrition 133(11).
- Kok SW, Overeem S, Visscher TLS, Lammers GJ, Seidell JC, Pijl H & Meinders AE (2003), Hypocretin deficiency in narcoleptic humans is associated with abdominal obesity, Obesity Research 11(9).
- Jazet IM, Pijl H & Meinders AE (2003), Adipose tissue as an endocrine organ: impact on insulin resistance, Netherlands Journal of Medicine 61(6).
- Muurling M, Mensink RP, Pijl H, Romijn JA, Havekes LM & Voshol PJ (2003), Rosiglitazone improves muscle insulin sensitivity, irrespective of increased triglyceride content, in ob/ob mice, Metabolism 52(8).
- Fogteloo AJ, Pijl H, Frolich M, McCamish M & Meinders AE (2003), Effects of recombinant human leptin treatment as an adjunct of moderate energy restriction on body weight, resting energy expenditure and energy intake in obese humans, Diabetes Nutrition and Metabolism 16(2).
- Buijs MM, Burggraaf J, Langendonk JG, Schoemaker RC, Frolich M, Arndt JW, Cohen AF, Romijn JA, Ackermans MT, Sauerwein HP, Meinders AE & Pijl H (2002), Hyposomatotropism blunts lipolysis in abdominally obese women, Journal of Clinical Endocrinology and Metabolism 87(8).
- Schoemaker RC, Buijs MM, Pijl H, Burggraaf J & Cohen AF (2002), Modeling the influence of growth hormone on lipolysis, Journal of Pharmacokinetics and Pharmacodynamics 29(2).
- Muurling M, Jong MC, Mensink RP, Hornstra G, Dahlmans VEH, Pijl H, Voshol PJ & Havekes LM (2002), A low-fat diet has a higher potential than energy restriction to improve high-fat diet-induced insulin resistance in mice, Metabolism 51(6).
- van Dam EWCM, Roelfsema F, Helmerhorst FH, Frolich M, Meinders AE, Veldhuis JD & Pijl H (2002), Low amplitude and disorderly spontaneous growth hormone release in obese women with or without polycystic ovary syndrome.
- Kok SW, Roelfsema F, Overeem S, Lammers GJ, Strijers RL, Frolich M, Meinders AE & Pijl H (2002), Dynamics of the pituitary-adrenal ensemble in hypocretin-deficient narcoleptic humans: Blunted basal adrenocorticotropin release and evidence for normal time-keeping by the master pacemaker, Journal of Clinical Endocrinology and Metabolism 87(11).
- Lindeman JHN, Pijl H, van Dielen FMH, Lentjes EGWM, van Leuven C & Kooistra T (2002), Ghrelin and the hyposomatotropism of obesity, Obesity Research 10(11).
- Kok SW, Meinders AE, Overeem S, Lammers GJ, Roelfsema F, Frolich M & Pijl H (2002), Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humans, Journal of Clinical Endocrinology and Metabolism 87(2).
- Van Dam EWCM, Roelfsema F, Veldhuis JD, Helmerhorst FM, Frolich M, Meinders AE, Krans HMJ & Pijl H (2002), Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS.
- Buijs MM, Romijn JA, Burggraaf J, De Kam ML, Cohen AF, Frolich M, Stellaard F, Meinders AE & Pijl H (2002), Growth hormone blunts protein oxidation and promotes protein turnover to a similar extent in abdominally obese and normal-weight women, Journal of Clinical Endocrinology and Metabolism 87(12).
- Koopmans SJ, Jong MC, Que I, Dahlmans VEH, Pijl H, Radder JK, Frolich M & Havekes LM (2001), Hyperlipidaemia is associated with increased insulin-mediated glucose metabolism, reduced fatty acid metabolism and normal blood pressure in transgenic mice overexpressing human apolipoprotein C1, Diabetologia 44(4).
- Iozzo P, Pratipanawatr T, Pijl H, Vogt C, Kumar V, Pipek R, Matsuda M, Mandarino LJ, Cusi KJ & DeFronzo RA (2001), Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis, AJP - Endocrinology and Metabolism 280(5).
- Burggraaf J, Lalezari S, Emeis JJ, Vischer UM, de Meyer PHEM, Pijl H & Cohen AF (2001), Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol, Thyroid 11(2).
- Bisschop PH, de Metz J, Ackermans MT, Endert E, Pijl H, Kuipers F, Meijer AJ, Sauerwein HP & Romijn JA (2001), Dietary fat content alters insulin-mediated glucose metabolism in healthy men, American Journal of Clinical Nutrition 73(3).
- Jong MC, Voshol PJ, Muurling M, Dahlmans VEH, Romijn JA, Pijl H & Havekes LM (2001), Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1, Diabetes 50(12).
- Pijl H, de Meijer PHEM, Langius J, Coenegracht GIGM, van den Berk AHM, Shaw PKC, Boom H, Schoemaker RC, Cohen AF, Burggraaf J & Meinders AE (2001), Food choice in hyperthyroidism: Potential influence of the autonomic nervous system and brain serotonin precursor availability, Journal of Clinical Endocrinology and Metabolism 86(12).
- Pijl H, Langendonk JG, Burggraaf J, Frolich M, Cohen AF, Veldhuis JD & Meinders AE (2001), Altered neuroregulation of GH secretion in viscerally obese premenopausal women, Journal of Clinical Endocrinology and Metabolism 86(11).
- Fogteloo AJ, Meinders AE, Pijl H, Kroon AA, Frolich M & De Leeuw PW (2001), Renal clearance of endogenous leptin in hypertensive humans with or without renal artery stenosis, AJP - Endocrinology and Metabolism 281(2).
- Burggraaf J, Tulen JHM, Lalezari S, Schoemaker RC, De Meyer PHEM, Meinders AE, Cohen AF & Pijl H (2001), Sympathovagal imbalance in hyperthyroidism, AJP - Endocrinology and Metabolism 281(1).
- Langendonk JG, Veldhuis JD, Burggraaf J, Schoemaker RC, Cohen AF, Meinders AE & Pijl H (2001), Estimation of growth hormone secretion rate: impact of kinetic assumptions intrinsic to the analytical approach, AJP - Regulatory, Integrative and Comparative Physiology 280(1).
- Pijl H, Romijn JA, Benthem L & Meinders AE (2000), Neuroendocrine sequelae of visceral fat accumulation: implications for cardiovascular disease and diabetes.
- Pijl H, Ohashi S, Matsuda M, Miyazaki Y, Mahankali A, Kumar V, Pipek R, Iozzo P, Lancaster JL, Cincotta AH & DeFronzo RA (2000), Bromocriptine - A novel approach to the treatment of type 2 diabetes.
- Bisschop PH, Arias AMP, Ackermans MT, Endert E, Pijl H, Kuipers F, Meijer AJ, Sauerwein HP & Romijn JA (2000), The effects of carbohydrate variation in isocaloric diets on glycogenolysis and gluconeogenesis in healthy men.
- de Maat MPM, Pijl H, Kluft C & Princen HMG (2000), Consumption of black and green tea has no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals, European Journal of Clinical Nutrition 54(10).