Research project
Physicochemical characterization of particulate drug delivery systems
Recently the pharmaceutical industry has become aware of a gap in our routine analytical methods to measure particles in pharmaceutical formulations. Especially the importance of protein aggregates in the sub-visible size range has gained major attention. This has led to the adoption of new techniques and implementation of existing techniques to cover sub-micron and micron-sized particles. Interestingly, these particle characterization methods are highly relevant to particulate drug delivery systems (DDS), such as liposomes, microspheres, nano-suspensions and micro-suspensions.
The aim of this project is the implementation of (novel) analytical methods to better characterize the above-mentioned DDS and improve their manufacturing processes. To this end, we apply particle characterization methods to analyze physicochemical properties (such as size, morphology, porosity) and stability of the DDS. Methods include nanoparticle tracking analysis, asymmetrical flow-field flow fractionation, resonant mass measurement and flow imaging microscopy. Moreover, we assess the behavior (e.g., aggregation, release characteristics) of the DDS under physiologically relevant conditions. The implemented methods can be used to guide process optimization of DDS production.