Discovery of metastasis promoting candidate drug targets. In a set of 2D cell migration assays that are amenable to high throughput microscopy screening using a large panel of human breast cancer cell lines, candidate target genes for interfering with tumor cell motility are identified. Clinical relevance of identified candidate targets in the context of metastasis is done together with hospitals. Clinically relevant candidate targets are further validated in 3D micro tissue models and ultimately in in vivo models for metastasis.