Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Promotor: Prof.dr. M.K. Richardson

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Promotor: Prof.dr. J. den Hertog

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Niet alleen evolutie stuurt verandering in soorten, het bouwplan van embryo’s bepaalt welke variaties echt ontstaan. Dat tonen Leidse biologen aan in een Nature-publicatie over de evolutionaire ontwikkeling van reptielpoten en vogelvleugels.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Existing work in probabilistic language modeling can be mostly divided into two categories: (i) Purely sequential, string-level approaches ensure fluency at the local level without notion of grammaticality and seek improvements in the use of massive training corpora. (ii) Fully structural, tree-based…

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotor: Prof.dr. E. Deprettere

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Peter Grunwald

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Promotor: B.van de Water, Co-promotor: L.S.Price

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Promotor: Prof. dr. A.G.G.M. Tielens

Promotor: P.D. Grünwald

Promotor: Prof.dr. F. den Hollander, G.Maillard

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

De mogelijkheden in de synthetische biologie en genetische modificatie blijven maar groeien. Maar waar ligt de grens? Het Leidse studententeam iGEM, dat zelf met genetisch gemodificeerde micro-organismen werkt, organiseerde op 18 oktober een discussieavond voor een breed publiek. ‘Het genetisch modificeren…