73 zoekresultaten voor “zebrafish” in de Publieke website
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Development of an in vitro vascular network using zebrafish embryonic cells
One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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noisy underwater world: the effect of sound on behaviour of captive zebrafish
Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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evaluating dose-response relationships of metal-based nanoparticles to Zebrafish embryos
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Key innate immune components controlling intracellular infection
Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer
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Develop a methodology for assessing the effective dose of nanomaterials for environmental risk assessment purposes
How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?
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Noortje DannenbergWiskunde en Natuurwetenschappen
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Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
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Through the magnifying glass
Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.
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Advancing Zebrafish Models in Proteomics
Promotie
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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The endocannabinoid system in zebrafish larvae
Promotie
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Zebrafish as vertebrate model of Gaucher disease
Promotie
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Computational optimisation of optical projection tomography for 3D image analysis
Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.
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Peptide amphiphiles and their use in supramolecular chemistry
Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Rationally designed peptide based functional biomaterials
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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Squaramide-based supramolecular polymers : from self-assembly to in vivo application
The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.
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noisy underwater world: The effect of sound on behaviour of captive zebrafish
Promotie
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Promotie
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Development of an in vitro vascular network using zebrafish embryonic cells
Promotie
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The use of zebrafish larvae for studying anxiety-like behaviour
Promotie
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
Promotie