Promotor: Prof.dr. M. Ubbink

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

The LOFAR radio telescope produces petabytes of data every year. Radio Astronomers use complex multi-step pipelines to process this data and produce scientific images.

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Promotor: Prof.dr. P.C. van Welzen

A scenario building web-tool and knowledge package to enable multi-level decision making for the transition to the Circular Economy

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

This thesis focus on the interaction between M dwarf stellar winds and Galactic cosmic rays and the possible effects on the habitability of exoplanets.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Promotor: Prof.dr. G.R. de Snoo

Electron microscopy has become an extremely important techniquein a wide variety of elds.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Promotor: Prof.dr. C.W.J. Beenakker

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

Join the Pipe is een project dat zich inzet om plastic afval te verminderen en mensen zowel in het Globale Zuiden als in het Globale Noorden van drinkbaar water te voorzien.

Mars is de vierde planeet vanaf de zon en soms aan de hemel te zien als rode stip. De afstand tot de zon is ongeveer 228 miljoen kilometer. Een rondje om de zon duurt 687 aardse dagen. Een dag duurt bijna net iets langer dan op aarde, 24 uur en 40 minuten.

Venus is de tweede planeet vanaf de zon en staat op 108 miljoen kilometer. Een jaar op Venus is korter dan op aarde en duurt maar 225 dagen. Doordat Venus heel langzaam om haar as draait, duurt een dag juist langer, wel 117 aarddagen! Op Venus is je alien dus elke twee dagen jarig.

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.

CML-IA is a database that contains characterisation factors for life cycle impact assessment (LCIA) and is easily read by the CMLCA software program.

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

Rachel Schats is Assistant Professor in Human Osteoarchaeology in the Faculty of Archaeology, Leiden University.

Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.

Promotor: H.J.A. Rottgering, Co-Promotor: R.J. van Weeren

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Promotie

Een techniek om CO2 om te zetten in brandstoffen en andere nuttige producten, is elektrolyse. Om dit efficiënt en op grote schaal te kunnen doen, moeten we wel precies begrijpen hoe elektrolyse werkt. Hoogleraar Marc Koper is expert op dit gebied.

Promotie

Promotie

Promotie

Promotie

Van waterzuiveringsinstallaties tot een lekkere warme douche, de CO2-uitstoot ten gevolge van het watergebruik in de VS staat gelijk aan dat van 50 miljoen auto’s die een jaar lang rondrijden. In The Washington Post raadpleegt journalist Tik Root verschillende experts om te leren over manieren om ons…

In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

Promotores: G.A. Persoon, H.H. de Iongh

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…