Promotor: W. Jiskoot, Co-promotor: A. Kros

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotores: Wim Jiskoot; Ferry Ossendorp

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

.

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Promotores: W. Jiskoot, F. Ossendorp

Bulgarije kwam relatief ongeschonden uit de eerste golf, maar in het najaar van 2020 namen het aantal infecties, ziekenhuisopnames en sterfgevallen sterk toe. Dit onderzoek analyseert hoe de Bulgaarse regering op de Covid-19 pandemie heeft gereageerd.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotie

Promotie

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotie

Promotie

Promotie

Promotie

Promotie

Promotie

Leidse chemici maakten in het lab de bacteriële capsule van meningokokken na. Met een paar aanpassingen kunnen deze capsules dienen als extra veilig en effectief vaccin tegen deze beruchte bacteriën, die onder andere hersenvliesontsteking kunnen veroorzaken. Promovendus Jacopo Enotarpi en zijn team…

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Tijdens de Leiden Science Family Day kom je op plekken die normaal voor het publiek gesloten blijven: ga backstage bij de faculteit der Wiskunde en Natuurwetenschappen!

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotie

Promotie

Promotie

Promotie

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

De kwaliteit van vaccins wordt nu nog vaak getest met behulp van proefdieren. Dat moet anders, vonden onderzoekers van de Universiteit Leiden en vaccinologisch instituut Intravacc. Samen gingen ze op zoek naar een testmethode die dierproeven overbodig maakt. De eerste veelbelovende resultaten zijn gepubliceerd…

Farmaceutisch bedrijf Janssen begint met de bouw van een nieuw kantoor- en laboratoriumgebouw op het Leiden Bio Science Park. De eerste paal van het 13.500 vierkante meter grote gebouw is inmiddels de grond in geslagen.

Een vaccin op basis van suikerjasjes heeft wel degelijk potentie om een multiresistente stafylokok te bestrijden. Dat betogen de Leidse Jeroen Codée en Sara Ali samen met Utrechtse collega’s in Nature. Ze bestrijden hiermee eerdere conclusies van Duitse collega’s.

In zijn oratie 'Op de juiste knopjes drukken' op 2 december spreekt prof.dr. Ferry Ossendorp over zijn onderzoek naar de inzet van het immuunsysteem tegen kanker.

There is a growing concern that AI programmes like ChatGPT exacerbate existing biases concerning gender, age, race and sexual orientation. As we are increasingly integrating the impressive abilities of AI programmes into companies, organisations and our personal lives, it is useful to take stock of…