66 zoekresultaten voor “vaccine” in de Publieke website
-
Adjuvanted nanoparticulate seasonal influenza vaccines
Promotor: W. Jiskoot, Co-promotor: A. Kros
-
Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
-
Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
-
Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
-
Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
-
Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
-
Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
- Elastin-like polypeptide micelles for vaccine delivery
-
Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine
.
-
Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine platform
Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.
-
Novel formulations and delivery strategies for inactivated polio vaccines : new routes with benefits
This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.
-
Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
-
from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
-
PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
-
The Bulgarian governments' response to Covid-19
Bulgarije kwam relatief ongeschonden uit de eerste golf, maar in het najaar van 2020 namen het aantal infecties, ziekenhuisopnames en sterfgevallen sterk toe. Dit onderzoek analyseert hoe de Bulgaarse regering op de Covid-19 pandemie heeft gereageerd.
-
Total Synthesis of Alginate and Zwitterionic Sp1 Oligosaccharides
The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.
-
Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
-
Towards controlled microneedle-mediated intradermal immunization
Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.
-
Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
-
Jeroen Codee
Wiskunde en Natuurwetenschappen
-
Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
-
Development of synthetic procedures towards immunostimulating carbohydrates
Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée
-
Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
-
Formulation of Peptide-Based Cancer Vaccines
Promotie
-
Cancer vaccine strategies to improve immunotherapy
Promotie
-
Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
-
Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
-
Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.
-
The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
-
Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
Promotie
-
Elastin-like polypeptide micelles for vaccine delivery
Promotie
-
Novel formulations and delivery strategies for inactivated poliovirus vaccines
Promotie
-
Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
Promotie
-
Towards the development of synthetic vaccines against tuberculosis
Promotie
-
Natural and Vaccine derived immunity against the human papillomavirus
Promotie
-
Een synthetisch vaccin tegen meningokokken
Leidse chemici maakten in het lab de bacteriële capsule van meningokokken na. Met een paar aanpassingen kunnen deze capsules dienen als extra veilig en effectief vaccin tegen deze beruchte bacteriën, die onder andere hersenvliesontsteking kunnen veroorzaken. Promovendus Jacopo Enotarpi en zijn team…
-
1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée
-
Science Experience Tours
Tijdens de Leiden Science Family Day kom je op plekken die normaal voor het publiek gesloten blijven: ga backstage bij de faculteit der Wiskunde en Natuurwetenschappen!
-
Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
-
transgenic rodent malaria parasites to improve live attenuated malaria vaccines
Promotie
-
Controlled human infection models as a tool for malaria and schistosomiasis vaccine research
Promotie
-
modification of Plasmodium falciparum and transgenic parasites in malaria vaccine research
Promotie
-
from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Promotie
-
Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
- 2 PhD Positions (1.0 FTE)
-
Vaccins testen zonder dierproeven?
De kwaliteit van vaccins wordt nu nog vaak getest met behulp van proefdieren. Dat moet anders, vonden onderzoekers van de Universiteit Leiden en vaccinologisch instituut Intravacc. Samen gingen ze op zoek naar een testmethode die dierproeven overbodig maakt. De eerste veelbelovende resultaten zijn gepubliceerd…
-
Farmaceutisch bedrijf Janssen breidt uit op Leiden Bio Science Park
Farmaceutisch bedrijf Janssen begint met de bouw van een nieuw kantoor- en laboratoriumgebouw op het Leiden Bio Science Park. De eerste paal van het 13.500 vierkante meter grote gebouw is inmiddels de grond in geslagen.
-
Suikerjasjes wel degelijk nuttig in zoektocht vaccin
Een vaccin op basis van suikerjasjes heeft wel degelijk potentie om een multiresistente stafylokok te bestrijden. Dat betogen de Leidse Jeroen Codée en Sara Ali samen met Utrechtse collega’s in Nature. Ze bestrijden hiermee eerdere conclusies van Duitse collega’s.
-
Oratie prof.dr. Ferry Ossendorp ‘Hoe bestuur je het immuumsysteem?’
In zijn oratie 'Op de juiste knopjes drukken' op 2 december spreekt prof.dr. Ferry Ossendorp over zijn onderzoek naar de inzet van het immuunsysteem tegen kanker.
-
Panel discussion: Bias in AI, algorithms and the tech sector - Young Alumni Network
There is a growing concern that AI programmes like ChatGPT exacerbate existing biases concerning gender, age, race and sexual orientation. As we are increasingly integrating the impressive abilities of AI programmes into companies, organisations and our personal lives, it is useful to take stock of…