136 zoekresultaten voor “tumor quantification” in de Publieke website
-
High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
-
Quantification of ecosystem services within river catchments
How can ecosystem services within river catchments be quantified in spatial and temporal explicit way?
-
Research Technician – tumor cell biology
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
-
Quantification in untargeted mass spectrometry-based metabolomics
Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers
-
Computational optimisation of optical projection tomography for 3D image analysis
Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.
-
Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
-
Fazel Abdolahpur MonikhWiskunde en Natuurwetenschappen
-
Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
-
Patiëntgericht onderzoek: minder over de tumor, meer over de patiënt
Amir Zamanipoor Najafabadi, arts en onderzoeker van de afdeling Neurochirurgie van het LUMC, onderzoekt hoe de behandeling van een meningeoom het leven van patiënten op de lange termijn beïnvloedt. Recentelijk verdedigde hij zijn proefschrift; een unieke gebeurtenis waarbij een patiënt onderdeel was…
-
Stereotactic Radiotherapy of Intracranial Tumors
Promotie
-
Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
-
Onderzoeksproject 'QUAD'
Onderzoeksproject 'QUAD'
-
PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
-
Sound Investigation: Effects of noise on marine animals across trophic levels
Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…
-
Cellular tumor biology
Oratie
-
The quantification of growth hormone secretion
Promotie
-
Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
-
Kankercellen onder de loep
Waarin verschilt een tumorcel van een gezonde cel? Die vraag proberen onderzoekers zo precies mogelijk te beantwoorden. Sommige verschillen kunnen dienen als aangrijpingspunt voor nieuwe therapieën.
-
Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
-
Innovatie in behandeling en zorg
De behandeling en zorg rondom kanker wordt steeds geavanceerder. Zo kunnen chirurgen veel preciezer gaan opereren en komen er therapeutische vaccins om het eigen immuunsysteem van de patiënt aan te sporen de kanker te bestrijden. Ook wordt er gewerkt aan betere vroegdiagnostiek en is er veel meer oog…
-
Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
-
Risk Quantification and Modification in Older Patients with Colorectal Cancer
Promotie
-
Medicijnen op maat
Er komen steeds meer medicijnen die op specifieke kenmerken van een tumor gericht zijn. De toepassing van chemotherapie wordt nog steeds verbeterd.
-
Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
-
Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
-
Kanker en erfelijkheid
Sommige mensen hebben aanleg om kanker te krijgen. Al bij de geboorte kunnen er mutaties in het erfelijk materiaal zitten die de kans op het krijgen van kanker verhogen. Onderzoekers nemen deze mutaties onder de loep om meer te weten te komen over hoe kanker ontstaat.
-
Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
-
Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
-
Applications of the tumor-stroma ratio; towards clinical implementation
Promotie
-
Unraveling Vascular Tumors: Combining Molecular and Computational Biology
Promotie
-
Immune cell complexity in the tumor microenvironment of breast cancer
Promotie
-
Novel Regulators of Prostate Cancer Stem Cells and Tumor Aggressiveness
Promotie
-
The tumor-stroma ratio in epithelial cancer types
Promotie
-
Ocular responses to foreign corneal and tumor tissue
Promotie
-
Computed tomography coronary angiography: From quantification of coronary atherosclerosis to risk stratification of patients
Promotie
-
Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
-
Pathogenese en therapie van kanker
Bij kanker groeien lichaamscellen ongecontroleerd. Het gedetailleerd in kaart brengen van hoe dit precies gebeurt maakt het mogelijk om efficiënte therapieën te ontwikkelen. Onderzoekers van het Leids Universitair Medisch Centrum (LUMC) en de Universiteit Leiden werken samen aan het vermeerderen van…
-
Substances from Cradle to Grave
Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…
-
Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
-
Exploring and Modulating the Tumor Immune Microenvironment Towards improving patient outcomes of immunotherapy in lung cancer
Promotie
-
Antiepileptic and antitumor treatment in brain tumor patients: impact of clinical and radiological outcome
Promotie
-
The Complex Interactions between the Tumor Microenvironment and Prostate and Oropharyngeal Cancer
Promotie
-
Overcoming barriers to T cell activation, infiltration and function in tumors
Promotie
-
Targeting stromal interactions in the pro-metastatic tumor microenvironment - Endoglin & TGF-β as (un)usual suspects
Promotie
-
inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Promotie
-
Fluorescence-guided cancer surgery, using clinical available and innovative tumor-specific contrast agents
Promotie
-
T cell immunity against MHC-I low tumors in mouse models
Promotie
-
Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
-
Modulating the behaviour of pancreatic tumour cells
Promotores: Prof.dr. M.K. Richardson, Prof.dr. H.P. Spaink. Co-promotor: C.P. Bagowski
-
Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen