262 zoekresultaten voor “treatment efficacy” in de Publieke website
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Worldwide Treatment Opportunities of Rheumatoid Arthritis
Promotie
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Vulvar cancer; pathogenesis, molecular genetics and treatment
Promotie
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Safety and efficacy after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model
Promotie
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Suze Zijlstra in Science Guide: hoe gaan we om met genderongelijkheid?
Afgelopen maandag was het Equal Pay Day: op deze dag staan we er bij stil dat vrouwen vaak minder verdienen voor hetzelfde werk. Maar hoe moet dit probleem worden aangepakt? Suze Zijlstra, universitair docent, publiceerde met Anna-Luna Post een artikel in Science Guide met de vraag waarom het altijd…
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Data science for tax administration
In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.
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Modulation of the immune system for treatment of atherosclerosis
Promotie
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Inflammation as a target for treatment in hand osteoarthritis
Promotie
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Systemic Treatment in Malignant Mesothelioma: Treat it or Leave it
Promotie
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Scratching beneath the surface: innovative treatment modalities for burn patients
Promotie
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Towards treatment of liver fibrosis; cells, targets and models
Promotie
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Optimising the treatment of patients with long bone metastases
Promotie
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Identification and Treatment of Patients at High Cardiovascular Risk
Promotie
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Developing an antisense oligonucleotide treatment for Spinocerebellar Ataxia Type 3
Promotie
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Improving diagnosis and treatment of gastrointestinal stromal tumour (GIST) patients
Promotie
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The search for new treatment strategies for malignant pleural mesothelioma
Promotie
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Combatting metabolic disease. Ethnic aspects, mechanisms and novel treatment strategies
Promotie
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Strategies in prevention and treatment of prosthetic joint infections
Promotie
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New Approaches to Imaging and Treatment of Ocular Melanoma
Promotie
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Intra-arterial treatment of acute ischemic stroke
Promotie
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Discrepancies in diagnoses and treatment of type B ankle fractures
Promotie
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Innovative cholinergic compounds for the treatment of cognitive dysfunction
Promotie
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Emerging Molecular Biomarkers and Treatment Strategies in Resectable Pancreatic Cancer
Promotie
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Medication related osteonecrosis of the jaws (MRONJ): Diagnosis & Treatment
Promotie
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Optimizing the positioning of novel mCRPC treatment options
Promotie
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Refining individualized treatment in older patients with breast cancer
Promotie
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Quality assurance in the surgical treatment of gastric cancer
Promotie
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Optimizing triage and treatment strategies in urinary tract infection
Promotie
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Medication related osteonecrosis of the jaws (MRONJ): Diagnosis & Treatment
Promotie
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Ovarian and fertility preservation prior to gonadotoxic treatment
Promotie
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Novel treatment for advanced thyroid cancer and elucidation of biomarkers
Promotie
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Swimming Bass under Pounding Bass: fish response to sound exposure
Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn
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Estimation and Optimization of the Performance of Polyhedral Process Networks
Promotor: Prof.dr.ir. E. Deprettere
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Exploring Deep Learning for Intelligent Image Retrieval
This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
Promotie
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Evaluatie en implementatie van innovatieve diagnostiek en behandelingen
Als een nieuwe methode is ontwikkeld om een (neuro-)psychologische aandoening of hieraan gerelateerde gedragsfactoren te herkennen en te behandelen, kan deze nog niet direct in de klinische praktijk worden ingezet. Eerst moet de methode geëvalueerd worden, bij voorkeur in gerandomiseerde, gecontroleerde…
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Fundamenteel onderzoek: Onderliggende mechanisme van ziekte en welzijn
Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.