Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Houden en fokken van proefdieren voor onderzoeks- en onderwijsdoeleinden.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Promotores: J. Zaanen, A. Parnachev

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Cardiovascular disease is the leading cause of death worldwide.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Promotor: P.D. Grünwald

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotor: Roeland M.H. Merks

The Leiden Ancient History specialization concentrates on the study of the economies, societies and cultures of the large empires of the Graeco-Roman world, starting with the empires of Alexander the Great and his successors. The appearance of these empires led to the development of an interaction network…

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Technologische ontwikkelingen staat nooit stil. Machines kunnen al veel taken overnemen, en in de toekomst waarschijnlijk nog meer. Welke beroepen worden hierdoor met uitsterven bedreigd en welke banen blijven nog wel een tijdje bestaan? Hoogleraar economie Olaf van Vliet bespreekt deze vraag in het…

Promotor: Prof.dr. E. Deprettere

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Promotie

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Promotor: B.van de Water, Co-promotor: L.S.Price

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Peter Grunwald

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Promotores: J. Jonkers, K.E. de Visser