414 zoekresultaten voor “transcription factors” in de Publieke website
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Functional analysis of Dof transcription factors controlling heading date and PPDK gene expression in rice
Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang
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MYC transcription factors: masters in the regulation of jasmonate biosynthesis in Arabidopsis thaliana
Promotor: J.M. Memelink
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and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis thaliana
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
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Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.
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Singing is silver, hearing is gold: impacts of local FoxP1 knockdowns on auditory perception and gene expression in female zebra finches
The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.
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The environmentally-regulated interplay between local three- dimensional chromatin architecture and gene expression
Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.
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Genetic and environmental factors determining heterogeneity in preservation stress resistance of Aspergillus niger conidia
Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.
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Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
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More JAZ in the orchestration of jasmonate-mediated plant defense
Prof.dr. J. Memelink
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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CML-IA Characterisation Factors
CML-IA is a database that contains characterisation factors for life cycle impact assessment (LCIA) and is easily read by the CMLCA software program.
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Pre- and perinatal risk factors
Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.
- The U-factor: van vwo naar wo
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
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MYC transcription factors: masters in the regulation of jasmonate biosynthesis in Arabidopsis thaliana
Promotie
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and Unraveling the Gene Regulatory Networks (GRNs) of HD-Zip Transcription Factor HB40 (and HB22) in Arabidopsis thaliana
Promotie
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computer programmes: the influence of genetic and neurobiological factors
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Histone-DNA assemblies in archaea. Shaping the genome on the edge of life
All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).
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Fully funded Ph.D. position – novel chemical modalities
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR), LACDR PhD Portal
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Belangrijke factor in uitzaaiing van borstkanker geïdentificeerd
Leidse onderzoekers ontdekten dat het eiwit annexine A1 een belangrijke rol speelt in uitzaaiing van borstkanker. Het reguleert de plasticiteit van cellen waardoor tumorcellen beweeglijk worden en kunnen uitzaaien. Dinsdag 23 maart publiceren ze hun resultaten in PNAS Online Early Edition.
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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‘Voedsel is onbetwistbaar een grote factor in ons watergebruik’
Van waterzuiveringsinstallaties tot een lekkere warme douche, de CO2-uitstoot ten gevolge van het watergebruik in de VS staat gelijk aan dat van 50 miljoen auto’s die een jaar lang rondrijden. In The Washington Post raadpleegt journalist Tik Root verschillende experts om te leren over manieren om ons…
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Anna Loh: ‘Kunst is de constante factor in mijn leven’
Anna Loh is een derdejaars student van de bacheloropleiding Arts, Media and Society. We spraken met Anna over hoe het is om een scriptie te schrijven tijdens COVID-19, Instagram-selfies in het museum en opgroeien in het buitenland.
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Impact factor for open access journal Research & Politics (RAP)
Research & Politics (RAP) is a peer-reviewed open access journal which focusses on research in political science and related fields through open access publication of the very best cutting-edge research and policy analysis. The journal achieved a high score for the impact factor, which puts it in 49th…
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Exploring Grainyhead-like 2 target genes in breast cancer
The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.
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Giant barrel sponges in diverse habitats: a story about the metabolome
Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.
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Unravelling molecular mechanisms in transcription-coupled nucleotide excision repair
Promotie
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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LC-Impact
How can we develop and further improve life cycle impact assessment methods, characterisation factors and normalisation factors?
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Interactions of nutrients and pesticides and their effects on aquatic macrofauna
Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?
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Delta hoogleraar Marco van Vulpen: ‘Ik pleit ervoor om de share-factor in te voeren’
Protonentherapie is een nieuwe manier om kanker te behandelen waarbij de bestralingsdoses preciezer worden afgegeven. Dit zorgt voor minder schade aan omliggend weefsel en minder bijwerkingen. Prof. dr. Marco van Vulpen is medisch directeur van HollandPTC in Delft waar wordt onderzocht wat de maatschappelijke…
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Veni voor Dovilė Rimkutė: Reputatie is de belangrijkste factor bij risicoregulering
Dovilė Rimkutė, universitair docent aan het Instituut Bestuurskunde in Den Haag, ontving de prestigieuze Veni-beurs voor haar onderzoek naar risicoregulering. ‘We gaan ervan uit dat beslissingen omtrent risicoregulering genomen worden op wetenschappelijk onderbouwde basis’, vertelt Rimkutė, ‘maar het…
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort
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Profinite groups with a rational probabilistic zeta function
Promotores: H.W. Lenstra, A. Lucchini
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Sound Investigation: Effects of noise on marine animals across trophic levels
Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…
- Onderhoud Multi Factor Authenticatie (MFA) omgeving
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Biophysical feedbacks between seagrasses and hydrodynamics in relation to grazing, water quality and spatial heterogeneity
Consequences for sediment stability and seston trapping
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On the amount of sieving in factorization methods
Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele
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Bayesian learning: challenges, limitations and pragmatics
This dissertation is about Bayesian learning from data. How can humans and computers learn from data?
- Geopolitiek en de menselijke factor (Den Haag)
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Host factors involved in Chikungunya virus replication
Promotie
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Comparative biology of common and grey seals along the Dutch coast
What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?
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Cardiometabolic risk factors and venous thrombosis
Promotie
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Emerging risk factors for venous thromboembolism
Promotie
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Factors affecting galanthamine production in Narcissus
Promotie
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Systematics, Epidermal defense and Bioprospecting of Wild Orchids
This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.