44 zoekresultaten voor “toxicity” in de Publieke website
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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Towards understanding the toxicity of copper nanoparticles in aquatic ecosystems
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
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Fate, accumulation and ecotoxicity of copper nanoparticles under environmentally relevant conditions
Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.
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Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic Species
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
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Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Effect of Nanoparticles on Microbial Catabolism and Community Structure using Biolog techniques
1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?
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DPD screening to prevent toxicity in fluoropyrimidine treated patient
Promotie
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Dynamics of TNFalpha signaling and drug-related liver toxicity
Promotie
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Adjuvant treatment for endometrial cancer: Efficacy, toxicity and quality of life
Promotie
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Determining the most appropriate dose metrics for evaluating dose-response relationships of metal-based nanoparticles to Zebrafish embryos
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Interactions of nutrients and pesticides and their effects on aquatic macrofauna
Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?
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Development of a consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?
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Develop a methodology for assessing the effective dose of nanomaterials for environmental risk assessment purposes
How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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Through the magnifying glass
Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.
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Effects of pesticides on aquatic macrofauna in the field
Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver
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Life Cycle Assessment of Nanomaterials and Risk Assessment.
What is the environmental impact, the human health impact and the life cycle and production costs of the lab, pilot and commercial diffusion of nanowires and nanowire-based photovoltaic technologies?
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NanoFeed
Do selenium nanoparticles in fish food cause subtle alterations in behavior of fish: effect of particles size and concentration?
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Metals in LCIA
A critical look at the impact assessment modelling of metals in Life Cycle Impact Assessment and improvement options.
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Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
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The use of computational toxicology in hazard assessment of engineered nanomaterials
Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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Biotic ligand models
Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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New Dutch LCA guide
Writing an operational guide to the ISO standards for LCA and related sub-projects.
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
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Florence Nightingale Colloquium presents Marta Fiocco
Lezing
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Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT)
Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)
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GLOBOX
GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.
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Promovendus maakt volledig werkend 3D-model van de lever
De Leidse promovendus Sreenivasa Ramaiahgari ontwikkelde voor het eerst een 3D-model van de lever. Zijn model kan een hoop besparen: schade bij patiënten, dierenleed en veel geld. Promotie 4 juni.
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Fazel Abdolahpur Monikh op Bessensap over de Nanomaterials Zoo
Lezing
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Nano shapes micro: Impacts of metallic nanoparticles on microbial communities
Promotie
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This Week's Discoveries | 15 October 2019
Lezing
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This Week’s Discoveries | 27 September 2016
Lezing
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How inclusion makes diversity work
Congres/symposium