203 zoekresultaten voor “targeted therapy” in de Publieke website
-
Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
-
Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
-
Postdoc – iPSC technology to discover targeted therapy for Nrf2 antioxidant response modulation.
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
-
Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
-
Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
-
Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
-
Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
- From basic research to therapy development for neuromuscular disorders
-
Postdoc candidate in biochemistry / cell glycobiology / protein targeted degradation
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
-
Clinical aspects of immunotherapy and targeted therapy of advanced melanoma
Promotie
-
Assistant Professor – bioinformatics in advanced therapy medicinal products
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
-
Targeted Therapy for Triple-Negative Breast Cancer
Promotie
-
CRISPR Cas-induced targeted mutagenesis with Agrobacterium mediated protein delivery
The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.
-
Targeting for success: Mechanistic insights into microRNA-based gene therapy for Huntington disease
Promotie
-
PhD candidate in Bioinformatics Safety Assessment of Gene and Cell Therapy
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
-
Promovendus legal and ethical aspects of stem cell-based gene therapy (1,0 fte)
Rechtsgeleerdheid, Instituut voor Privaatrecht
-
Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
Promotie
-
Targeted Informed consent: empowering young participants in medical-scientific research
Promotor: J.M. van den Broek Co-promotor: M.C. de Vries
-
characterization of uveal melanoma patients treated with proton beam therapy
Promotie
-
Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
-
eLaw organiseert paneldiscussie 'Online Targeted Advertising and Human Dignity'
eLaw is verheugd u te kunnen laten weten dat we op 29 april (17: 00-19: 00) prof. Luciano Floridi, prof. Brett Frischmann en prof. Shoshana Zuboff online zullen ontvangen voor een paneldiscussie via zoom .
-
Haico van AttikumFaculteit Geneeskunde
-
Theo AnagnostopoulosWiskunde en Natuurwetenschappen
-
Promotie 'Art therapy & Anxiety' Annemarie Madani-Abbing
Op 22 januari 2020 verdedigt Annemarie Madani-Abbing haar proefschrift 'Art Therapy & Anxiety'.
-
Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
-
The Metallophilic Interaction between Cyclometalated Complexes: Photobiological Applications
In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.
-
Judith BovéeFaculteit Geneeskunde
-
Marike KooistraFaculteit der Sociale Wetenschappen
-
Lioe-Fee de Geus-OeiFaculteit Geneeskunde
-
The gendered micropolitics of hiding and disclosing: assessing the spread and stagnation of information on two new EMTCT policies in a Malawian
Announcement of a new publication by Janneke Verheijen, lecturer at the Institute of Cultural Anthropology and Development Sociology.
-
Preparing for CADASIL therapy
Promotie
-
Art therapy & Anxiety
Promotie
-
Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
-
Paneldiscussie 'Online Targeted Advertising and Human Dignity'
Debat
-
Fluorescence-guided surgery: Clinical translation of targeted and non- targeted dyes
Promotie
-
Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
-
Surgical therapy of organic mitral valve disease
Promotie
-
Music therapy in Huntington's disease
Promotie
-
GMP-faciliteit voor innovatieve geneesmiddelen (KFT-J10 / IGFL)
De GMP-faciliteit maaktde ontwikkeling en productie van Advanced Therapy Medicinal Products (ATMP's) en chemische (peptide) synthese mogelijk.
-
Computational modeling of cellular dynamics in tumor cell migration
Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.
-
Silicon pore optics for high-energy optical systems
This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.
-
Peptide amphiphiles and their use in supramolecular chemistry
Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros
-
Rational empiric antibiotic therapy in clinical practice & policy making
Promotie
-
Immune modulation and monitoring of cell therapy in inflammatory disorders
Promotie
-
Clinical pharmacometrics to optimize immunosuppressive therapy in kidney transplantation
Promotie
-
Host-Directed Therapy for Intracellular Bacterial Infections
Promotie
-
Mechanisms of melanoma-targeting antibody therapy in mice
Promotie
-
Therapeutic RNAi-based gene therapy for neurodegenerative disorders
Promotie
-
Diagnostic and Intraoperative Targeted Molecular Imaging for Pancreatic Cancer
Promotie
-
Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.