Deze opleiding is gericht op de ontwikkeling van computermodellen die de werking van medicijnen voorspellen, het individualiseren van bestaande behandeltherapieën en het ontwikkelen van innovatieve, analytische tools voor het personaliseren van de gezondheidszorg.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: S.M. Verduyn Lunel

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Meer leren over het ontstaan van het leven op Aarde? Dat kan in de Summerschool Crises in Biology.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Op 3 oktober streed een team van het Instituut Biologie Leiden tegen andere universitaire biologenteams in de Biology Battle of the Universities. Het team behaalde de tweede plaats.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Prof.dr. Geert de Snoo is per 1 maart bij de Faculteit der Wiskunde en Natuurwetenschappen benoemd tot hoogleraar Conservation Biology. De Snoo blijft hoofd van de gelijknamige afdeling van het Institute of Environmental Sciences (CML).

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Docenten spelen een cruciale rol bij het implementeren van onderwijsvernieuwingen. Uiteindelijk hangt het succes van de implementatie af van de manier waarop docenten de vernieuwing vormgeven in hun dagelijkse lespraktijk.

Promotores: W. Jiskoot, F. Ossendorp

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Promotor: Prof.dr. M. Ubbink

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Promotor: Prof.dr. J. Kuiper

Op 17 december 2018 verdedigde Dejian Kong zijn proefschrift 'Civil Liability for Damage caused by Global Navigation Satellite System'. Het promotieonderzoek is begeleid door promotor prof. dr. P.M.J. Mendes de Leon.

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.

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Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Promotie

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov