The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promotie

Promotor: S.M. Verduyn Lunel

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

What are the flows of C&DW (e.g. bricks, concrete, gypsum and wood) in the case study countries ? How to define the specification for each material to be quantified? What indicators should be used to identify the pattern of each C&DW management system? How to interpret the MFA results in relation…

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotor: Prof.dr. E. Deprettere

... which focuses on the development and use of new multivariate statistical tools needed for analyses of data collected in the four other programs.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Promotor: Prof.dr. B. van de Water

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Co-ordination Action for Innovation in Life-Cycle Analysis for Sustainability: deepening, broadening and leaping forward the LCA methodology.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Analytical tools for environmental design and management in a systems perspective. The combined use of analytical tools.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Het Computer Systems, Imagery & Media (CSI) onderzoeksprogramma voert fundamenteel onderzoek uit naar methoden en technieken voor het ontwerp, de implementatie en de applicatie van geavanceerde computersystemen.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

De masteropleiding Cultural Analysis: Literature and Theory van de Universiteit Leiden richt zich op de studie van literatuur vanuit een vergelijkend en theoretisch perspectief, en onderzoekt de literatuur van een breed spectrum van talen en culturen uit de hele wereld.

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

This thesis is based on five papers on several topics.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Can we develop a platform for raw materials intelligence?

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

Deze opleiding is gericht op de ontwikkeling van computermodellen die de werking van medicijnen voorspellen, het individualiseren van bestaande behandeltherapieën en het ontwikkelen van innovatieve, analytische tools voor het personaliseren van de gezondheidszorg.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

This interdisciplinary research project explores several adaptive machine learning methods which can give insight into the interaction between human and machine. The ultimate goal is open and natural communication between humans and AI that should result in mutual trust, cooperation and coordination…

Supervisor: P.J.J. Hooykaas

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.