Promotie

Lezing, Tatiana Afanassjewa-lezing

Promotie

Promotie

Promotie

Promotie

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

This thesis describes the design, characterization and application of dextran based crosslinked network.

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Promotor: Prof.dr. H.L.V. Linnartz

Wij richten ons op natuurlijke producten van onderzoek, de traditionele geneeskunde, etnobotanie en fytochemie.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

My work focuses on a class of astronomical objects called protoplanetary disks.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

Promotor: M.T.M. Koper, Co-promotors: A.I. Yanson, L.B.F. Juurlink

Chemicus Rik Mom krijgt via NWO een tenure track-positie bij het Leids Instituut voor Chemisch onderzoek, waar hij in 2017 cum laude promoveerde. Mom gaat onderzoek doen naar het opslaan van duurzame energie door middel van het splitsen van water. Met nieuwe methoden zal hij op atomaire schaal onderzoeken…

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Overkleeft

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Promotor: H.J.M. de Groot

De natuur is een onuitputtelijke inspiratiebron voor de wetenschappers van het Instituut Biologie Leiden (IBL). Vanuit het streven naar fundamenteel begrip van de natuur zoeken zij naar oplossingen op het gebied van gezondheid en behoud van de biodiversiteit. Het thema van het instituut is ‘Harnessing…

Natuurkundigen van het LION doen fundamenteel onderzoek naar natuurkundige verschijnselen, gedreven door nieuwsgierigheid en de wens om de kennis over de wereld waarin wij bestaan te vergroten. Dergelijk onderzoek is altijd een wegbereider gebleken naar toepassingen, en daar hebben de LION onderzoekers…