135 zoekresultaten voor “super-resolution microscopy” in de Publieke website
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Magnetic Resonance Force Microscopy and the Spin Bath
There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.
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Cryo-electron microscopy scientist
Wiskunde en Natuurwetenschappen
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eV-TEM: Transmission Electron Microscopy with few-eV Electrons
Electron microscopy has become an extremely important techniquein a wide variety of elds.
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Probing quantum materials with novel scanning tunneling microscopy techniques
This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.
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Quantitative Super-Resolution Microscopy
Promotie
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Transmission electron microscopy on live catalysts
The dissertation describes TEM experiments on heterogeneous catalysts.
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Low-Energy Electron Microscopy on Two-Dimensional Systems: Growth, Potentiometry and Band Structure Mapping
Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.
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Josephson and noise scanning tunneling microscopy on conventional, unconventional and disordered superconductors
In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…
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mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Lasers, lenses and light curves: adaptive optics microscopy and peculiar transiting exoplanets
Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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Visualizing strongly-correlated electrons with a novel scanning tunneling microscope
Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.
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Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.
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Huub de Groot
Wiskunde en Natuurwetenschappen
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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The origins of friction and the growth of graphene, investigated at the atomic scale
Promotor: J.W.M. Frenken
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A new method to reconstruct the structure from crystal images
Promotor: J.P. Abrahams, Co-promotor: T. Grüne
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Functional fluorescent materials and migration dynamics of neural progenitor cells
In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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Transmission Electron Microscopy on live catalysts
Promotie
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Magnetic Resonance Force Microscopy for Condensed Matter
Promotie
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Microcoil MRI of Plants and Algae at Ultra-High Field: An exploration of metabolic imaging
This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).
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Research technician (1,0 fte; temporary position for 1 year)
Wiskunde en Natuurwetenschappen, Leids Instituut voor Onderzoek in de Natuurkunde (LION)
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Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
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Photothermal circular dichroism studies of single nanoparticles
In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.
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Advances in SQUID-detected Magnetic Resonance Force Microscopy
Promotie
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
Promotie
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Probing quantum materials with novel scanning tunneling microscopy techniques
Promotie
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eV-TEM: Transmission Electron Microscopy with few-eV Electrons
Promotie
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Nuclear magnetic resonance force microscopy at millikelvin temperatures
Promotie
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Magnetic Resonance Force Microscopy and the Spin Bath
Promotie
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Natuurkundige Michel Orrit nieuw lid KNAW
De Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) kiest haar leden uit een select gezelschap van vooraanstaande onderzoekers. Op 17 september installeert de KNAW 21 nieuwe leden, waaronder Leids natuurkundige Michel Orrit.
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Ariane Briegel in NRC Handelsblad over supermicroscoop
Een speciaal type microscoop jaagt momenteel een revolutie aan in de biologie: de cryo-elektronenmicroscoop. Twee van zulke giganten staan sinds 2011 op de Leidse Faculteit der Wiskunde en Natuurwetenschappen. Hoogleraar Ultrastructuurbiologie Ariane Briegel vertelt hierover in het NRC Handelsblad.
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Michel Orrit en Hermen Overkleeft lid KNAW
De Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) kiest haar leden uit een select gezelschap van vooraanstaande onderzoekers. Op 17 september installeert de KNAW 21 nieuwe leden, onder wie Leids natuurkundige Michel Orrit en chemicus Hermen Overkleeft.
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Systems microscopy to unravel cellular stress response signaling in drug induced liver injury
Promotie
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Kleinste Universiteit Leiden-logo gemaakt
Het logo van de Universiteit Leiden, met letters zo klein als een bacterie. Wetenschappers van het LUMC en het Instituut Biologie hebben het kleinste logo ooit van onze universiteit gemaakt. Een grapje met een serieuze ondertoon: met de nieuwe microscoop waarmee het logo is gemaakt, kunnen zij nog gedetailleerder…
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High throughput microscopy of mechanism-based reporters in Drug- induced liver injury
Promotie
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
Promotie
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The electrode-electrolyte interface in CO2 reduction and H2 evolution: a multiscale approach
Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
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Photon detection at subwavelength scales
Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood
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Network flow algorithms for discrete tomography
Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.