Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

Promotor: Prof.dr. M.A.G.J. Orrit

Woensdag 14 juli publiceerden Nederlandse astronomen een primeur in vakblad Nature. Het was hen als eersten ter wereld gelukt om isotopen te ontwaren in de damkring van een exoplaneet. Een ontdekking die ons meer kan leren over het ontstaan van planeten. Verschillende media schreven over de bijzondere…

Lezing, Studium Generale

Nieuwe koolstofdateringen van schelpen wijzen erop dat moderne mensen al minstens 45.900 jaar geleden in de Levant in Zuidwest-Azië leefden en van daaruit Europa koloniseerden. Dat is een paar duizend jaar eerder dan tot nu toe werd gedacht.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Promotie

Als je de standaard waterstofatomen in ijs vervangt door een zwaardere variant dan gebeurt er iets geks. Het volume dat de moleculen innemen groeit met 0,1 procent. De Leidse chemicus Jörg Meyer en zijn collega’s hebben een theoretisch model gemaakt dat dit gedrag beschrijft. Hun onderzoek verscheen…

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

This paper describes the development process of voting behavior in Chile; particularly the relationship between the class voting theory and the theory of cultural post-materialist vote is investigated. This research deals with Chile as a case study, a developing country with a relatively stable democracy…

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Examining if large scale application of new energy pathways can be constrained by materials and emissions.

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotie

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

Promotor: J.W. van Holten

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

In the first part of this thesis we study the geometry of folding patterns.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

What happens to electrical waves that have to cross gaps in insulation material around nerves in the human body

Promotie

Promotie

Lezing

Cool Little Kids is een onderzoeksproject ter preventie van angstproblemen bij verlegen en teruggetrokken kinderen van 3-6 jaar

Modern optimization algorithms offer solutions for architectural decisions like spatial, structural and energy efficiency. A young computer scientist from Leiden University co-authored a paper that won the Best Paper Award at a leading conference in Krakow during the summer.

Vier jonge Leidse onderzoekers kunnen met een Rubiconsubsidie van NWO naar het buitenland. En net als voorgaande jaren komt tegen de bedoeling van de Rubicon een Nederlandse onderzoeker van een andere universiteit naar Leiden.

Zijn om elkaar heen draaiende zwarte gaten langzaam naar elkaar toegedreven? Of zijn ze bij elkaar in de buurt ontstaan? Leids astronoom Simon Portegies Zwart berekende samen met twee Amsterdamse collega's dat het tweede scenario behoorlijk waarschijnlijk is.

Er is weer nieuws over het eiwit alpha-Synucleine. dat een belangrijke rol wordt toegedicht bij de ziekte van Parkinson. Biofysicus Martina Huber e.a. laten zien op welke manier deze eiwiten samenklonteren als ze met een membraan in contact komen. Hun artikel in de Journal of the American Chemical Society…

Promotie