Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Statistical distributions in LCA and converting between different representations of these distributions.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

The objective of this study is to better understand the distribution of microplastics in the environment. More specifically, we will quantify the abundance and distribution of microplastics on beaches.

What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

De wereldwijde ongelijkheid neemt steeds meer toe. Het is belangrijk om de oorzaken te weten zodat de toenemende ongelijkheid bestreden kan worden.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Does the presence of Ring-necked parakeets negatively influence feeding and feeding behaviour of native bird species on artificial bird feeders and if so, what are possible solutions?

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

How can we quantify the density of species within a community through environmental DNA concentrations?

Promotor: Roeland M.H. Merks

Promotor: Prof.dr. G.R. de Snoo

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Does a mid-season fire impact invertebrate populations?

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

Komen medicijnen in de juiste hoeveelheid aan op de juiste plek in ons brein? Door een model te maken dat ons brein in kleine ‘hersenblokjes’ weergeeft, probeert Esmée Vendel hier een antwoord op te vinden. Haar nieuwe, wiskundig model voorspelt de medicijnconcentratie in de hersenen over tijd én ruimte.…

What impact does a mid-season wildfire have on grassland invertebrates?

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: Prof.dr. E. Smets, M. Stech

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Promotor: Prof.dr. E. Deprettere

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: B.van de Water, Co-promotor: L.S.Price

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Promotor: Prof.dr. J.N. Kok

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Promotor: Prof.dr. B.R. Katzy

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

... which builds on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

Promotor: E. Gittenberger, Co-promotores: B.W. Hoeksema; L.P. van Ofwegen

Do selenium nanoparticles in fish food cause subtle alterations in behavior of fish: effect of particles size and concentration?

Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink