The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

Promotor: Prof.dr. T. Hankemeier

Promotor: Prof.dr. M. Ubbink

NNMT wordt beschouwd als een nieuw potentieel farmacologisch doelwit in de behandeling van een verscheidenheid van kankers, stofwisselingsziekten en andere pathologieën. Het toenemend aantal publicaties waarin de rol van NNMT bij ziekten wordt opgehelderd, heeft op zijn beurt de ontwikkeling van krachtige…

Promotor: M. Ubbink, Co-promotor: G. Siegal

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

Promotores:Th.J.C. van Berkel, M. van Eck

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Zelfs een kleine quantumcomputer zou in staat moeten zijn om de eigenschappen en het gedrag van nieuwe moleculen exact te simuleren. Dit zou de chemie naar een nieuw niveau tillen. Betere zonnepanelen, krachtiger batterijen, grote energiebesparingen in de chemische industrie: de toepassingen hebben…

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Dishoeck

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Schneider

Sinds de United Nations Group of Governmental Experts on the Developments in the Field of Information and Telecommunications in the Context of International Security (UN GGE) elf aanbevelingen heeft gedaan over verantwoordelijk staatsgedrag omtrent cyberspace is er een discussie gaande over internationale…

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

Promotor: A.P. IJzerman

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Promotor: E. Bouwman, Co-promotor: S. Bonnet

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

Promotor: Prof.dr. E. F. van Dishoeck

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

Promotor: Prof.dr. G.J. Kroes

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

How does the management of Elephant Marsh Fishery in Malawi relate to wider contexts of policies, theories and regions? And how can the current management system be adapted to achieve long-term sustainability of the fishery?

Promotor: Prof.dr. M.A.G.J. Orrit

Op 18 juni 2019 verdedigde Neta Palkovitz Menashy haar proefschrift 'Regulating a Revolution: Small Satellites and the Law of Outer Space'. Het promotieonderzoek is begeleid door promotoren prof. dr. P.M.J. Mendes de Leon en prof. dr. G. Molier.

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Promotie

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Dankzij bepaalde vet-suikermoleculen kunnen onder meer leprabacteriën zich verstoppen voor ons immuunsysteem. Hoe precies, is niet helemaal duidelijk. Hessel van Dijk, die op 13 oktober promoveerde, maakte de moleculen na en hielp daarmee een stukje van de puzzel op te lossen. Van Dijks proefschrift…

Promotor: M.A.G.J. Orrit

Walsh

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Schneider

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot