137 zoekresultaten voor “skin barrier repair” in de Publieke website
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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A novel formulation for skin barrier Repair
Promotie
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Lipids as therapeutic targets for barrier repair in skin diseases
Promotie
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Promotie R. Rissmann
Op dinsdag 17 maart promoveert Robert Rissmann van het LACDR. De titel van zijn proefschrift luidt "A novel strategy to improve skin barrier function and repair".
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Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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Miljoenen mensen te helpen met nieuwe synthetische huidcrème
Een team onderzoekers is erin geslaagd de meest natuurlijk huidcrème die er bestaat, na te maken. Met behulp van de DUBBLE bundellijnen (Dutch Belgian Beamline) bij de European Synchrotron Radiation Facility (ESRF) in Grenoble waren de onderzoekers in staat de samenstelling en de structuur van vernix…
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermaitits skin
Promotie
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multidirectional approach to optimize morphogenesis and barrier characteristics of human skin equivalents
Promotie
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DNA repair in chromatin: the cancer connection
Lezing
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‘Gemeentegrenzen kunnen barrières zijn’
Agglomeraties presteren minder goed dan steden met één bestuur. Dat blijkt uit onderzoek van Ton van Raan, professor kwantitatief wetenschapsonderzoek.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Hoge barrières voor de inzet van kroongetuigen in Nederland
In vergelijking met andere landen zijn de barrières in Nederland om tot inzet van kroongetuigen te komen hoog. Dat concluderen Leidse rechtsgeleerden in het vandaag verschenen onderzoeksrapport ‘Collaboration with Justice in the Netherlands, Germany, Italy and Canada’. Het rapport geeft een unieke inkijk…
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Gene therapy and nerve repair
Promotie
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Child maltreatment under the skin
Promotie
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Prijs voor 'Breaking down barriers' project van Afrika-Studiecentrum en Liliane Fonds
Het Liliane Fonds en het Afrika-Studiecentrum van de Universiteit Leiden hebben de Impact Challenge Award 2019 gewonnen voor het project 'Breaking down barriers to exclusion. Building capacity for lobby and advocacy for children with disabilities'. De Impact Challenge Award is een nationale onderscheiding…
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The Building Blocks For Cardiac Repair
Promotie
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Extracellular vesicle therapeutics for cardiac repair
Promotie
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Development of human skin equivalents mimicking skin aging: contrast between papillary and reticular fibroblasts as a lead
Promotie
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(Anti)sense and sensibility: renal and skin effects of oligonucleotides
Promotie
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Chromatin modifiers in DNA repair and human disease
Promotie
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The skin as a mirror of the aging process
Promotie
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Adenoviral vectors as genome editing tools: repairing defective DMD alleles
Promotie
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The role of quiescent and cycling stem cells in the development of skin cancer
Promotie
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Crossing barriers: delivery of llama antibody fragments into the brain
Promotie
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FutureTDM Knowledge Cafe: Exploring Barriers to EU Text and Data Mining
Congres/symposium
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Molecular pathways involved in renal injury-repair and ADPKD progression
Promotie
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Towards controlled microneedle-mediated intradermal immunization
Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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Exposure and health Assessment of Persistent Organic Pollutants (POPs) at e-waste recycling site among workers in the informal sector in Nigeria
Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Manipulating carbon nanotubes Towards the application as novel field emission sources
Promotores: T.H. Oosterkamp, N. de Jonge
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Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT)
Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)
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Maatschappelijke Meerwaarde
Het doorvoeren van allerlei veranderingen, introduceren van nieuwe structuren, verdergaande regels en administratieve systemen lijken soms af te leiden van het bestaansrecht of de publieke opgave van de organisatie. Bovendien komt er meer erkenning voor de behoefte van medewerkers in publieke organisaties…
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Waves and Patterns in Discrete Media: Bridging the Gaps
What happens to electrical waves that have to cross gaps in insulation material around nerves in the human body
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Semi-empirical approach to the simulation of molecule-surface reaction dynamcis
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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De Quantumcomputer
De wereldwijde race naar de quantumcomputer is in volle gang. Deze computer kan rekenklussen aan waarvan we nu alleen maar dromen, zoals het razendsnel vinden van eiwitten die als medicijn kunnen dienen. Leidse natuurkundigen ontdekten hoe je het Majorana-deeltje als bouwsteen voor deze quantumcomputer…
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Aandacht voor de bloed-hersenbarrière door en voor neurowetenschappers uit Nederland
Als onderdeel van Brain Awareness Week 2013, organiseert BBBNedwork op vrijdag 22 maart haar kick-off meeting in Leiden. Op dit symposium zullen verschillende (neuro)wetenschappers samenkomen om de centrale rol van de bloed-hersenbarrière in de behandeling van hersenaandoeningen te bespreken.