206 zoekresultaten voor “skin barrier repair” in de Publieke website
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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culture medium based approach to optimize the stratum corneum barrier of human skin equivalents
uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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A novel formulation for skin barrier Repair
Promotie
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Lipids as therapeutic targets for barrier repair in skin diseases
Promotie
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Imaging the (un)imaginable of the Barrier Immune System
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Promotie R. Rissmann
Op dinsdag 17 maart promoveert Robert Rissmann van het LACDR. De titel van zijn proefschrift luidt
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‘Gemeentegrenzen kunnen barrières zijn’
Agglomeraties presteren minder goed dan steden met één bestuur. Dat blijkt uit onderzoek van Ton van Raan, professor kwantitatief wetenschapsonderzoek.
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Hoge barrières voor de inzet van kroongetuigen in Nederland
In vergelijking met andere landen zijn de barrières in Nederland om tot inzet van kroongetuigen te komen hoog. Dat concluderen Leidse rechtsgeleerden in het vandaag verschenen onderzoeksrapport ‘Collaboration with Justice in the Netherlands, Germany, Italy and Canada’. Het rapport geeft een unieke inkijk…
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
Promotie
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multidirectional approach to optimize morphogenesis and barrier characteristics of human skin equivalents
Promotie
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culture medium based approach to optimize the stratum corneum barrier of human skin equivalents
Promotie
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membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Promotie
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Prijs voor 'Breaking down barriers' project van Afrika-Studiecentrum en Liliane Fonds
Het Liliane Fonds en het Afrika-Studiecentrum van de Universiteit Leiden hebben de Impact Challenge Award 2019 gewonnen voor het project 'Breaking down barriers to exclusion. Building capacity for lobby and advocacy for children with disabilities'. De Impact Challenge Award is een nationale onderscheiding…
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DNA repair in chromatin: the cancer connection
Lezing
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Towards controlled microneedle-mediated intradermal immunization
Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.
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High fidelity DNA replication and repair
Promotie
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Germline variants in the mismatch repair genes
Promotie
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The Building Blocks For Cardiac Repair
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Extracellular vesicle therapeutics for cardiac repair
Promotie
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Enhancing epicardial EMT to repair the heart
Promotie
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Barrier Free Studying Lunch Meeting
Lezing
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Nucleotide excision repair: from molecular mechanisms to patiënt phenotypes
Promotie
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Unravelling molecular mechanisms in transcription-coupled nucleotide excision repair
Promotie
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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The role of quiescent and cycling stem cells in the development of skin cancer
Promotie
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Wiles and Wanderings: Immune-evasive maneuvers of skin-penetrating parasites
Promotie
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Investigation of skin inflammation with a novel dermatology toolbox for early phase clinical drug development
Promotie
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The diverse roles of integrin α3β1 in cancer: lessons learned from skin and breast carcinogenesis
Promotie
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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Molecular pathways involved in renal injury-repair and ADPKD progression
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Mechanisms underlying mutational outcomes of DNA double-strand break repair
Promotie
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Manipulating carbon nanotubes Towards the application as novel field emission sources
Promotores: T.H. Oosterkamp, N. de Jonge