169 zoekresultaten voor “skin barrier” in de Publieke website
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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culture medium based approach to optimize the stratum corneum barrier of human skin equivalents
uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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A novel formulation for skin barrier Repair
Promotie
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Imaging the (un)imaginable of the Barrier Immune System
Promotie
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
Promotie
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membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Promotie
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Lipids as therapeutic targets for barrier repair in skin diseases
Promotie
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‘Gemeentegrenzen kunnen barrières zijn’
Agglomeraties presteren minder goed dan steden met één bestuur. Dat blijkt uit onderzoek van Ton van Raan, professor kwantitatief wetenschapsonderzoek.
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Promotie R. Rissmann
Op dinsdag 17 maart promoveert Robert Rissmann van het LACDR. De titel van zijn proefschrift luidt
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culture medium based approach to optimize the stratum corneum barrier of human skin equivalents
Promotie
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multidirectional approach to optimize morphogenesis and barrier characteristics of human skin equivalents
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Hoge barrières voor de inzet van kroongetuigen in Nederland
In vergelijking met andere landen zijn de barrières in Nederland om tot inzet van kroongetuigen te komen hoog. Dat concluderen Leidse rechtsgeleerden in het vandaag verschenen onderzoeksrapport ‘Collaboration with Justice in the Netherlands, Germany, Italy and Canada’. Het rapport geeft een unieke inkijk…
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Prijs voor 'Breaking down barriers' project van Afrika-Studiecentrum en Liliane Fonds
Het Liliane Fonds en het Afrika-Studiecentrum van de Universiteit Leiden hebben de Impact Challenge Award 2019 gewonnen voor het project 'Breaking down barriers to exclusion. Building capacity for lobby and advocacy for children with disabilities'. De Impact Challenge Award is een nationale onderscheiding…
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Towards controlled microneedle-mediated intradermal immunization
Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.
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Barrier Free Studying Lunch Meeting
Lezing
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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Wiles and Wanderings: Immune-evasive maneuvers of skin-penetrating parasites
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The role of quiescent and cycling stem cells in the development of skin cancer
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Investigation of skin inflammation with a novel dermatology toolbox for early phase clinical drug development
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The diverse roles of integrin α3β1 in cancer: lessons learned from skin and breast carcinogenesis
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
- ELS lab meeting - Journal Club: What went wrong? Methodological barriers to ELS by Jessie Pool
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Miljoenen mensen te helpen met nieuwe synthetische huidcrème
Een team onderzoekers is erin geslaagd de meest natuurlijk huidcrème die er bestaat, na te maken. Met behulp van de DUBBLE bundellijnen (Dutch Belgian Beamline) bij de European Synchrotron Radiation Facility (ESRF) in Grenoble waren de onderzoekers in staat de samenstelling en de structuur van vernix…
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Overcoming barriers to T cell activation, infiltration and function in tumors
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integrated Youth Care: a qualitative evaluation of facilitators and barriers for professionals
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De Quantumcomputer
De wereldwijde race naar de quantumcomputer is in volle gang. Deze computer kan rekenklussen aan waarvan we nu alleen maar dromen, zoals het razendsnel vinden van eiwitten die als medicijn kunnen dienen. Leidse natuurkundigen ontdekten hoe je het Majorana-deeltje als bouwsteen voor deze quantumcomputer…
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Emily Strange
Co-creatie en multidisciplinair leren over grenzen heen
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Breaking Barriers, Personalizing Pathways - Psychological health and self-management of people with chronic kidney disease
Promotie
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Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT)
Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Maatschappelijke Meerwaarde
Het doorvoeren van allerlei veranderingen, introduceren van nieuwe structuren, verdergaande regels en administratieve systemen lijken soms af te leiden van het bestaansrecht of de publieke opgave van de organisatie. Bovendien komt er meer erkenning voor de behoefte van medewerkers in publieke organisaties…
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Poiesis and the Performance Practice of Physically Polyphonic Notations
Kevin speelt hedendaags repertoire dat zich onderscheidt doordat de lichamelijk handelingen die nodig zijn om deze muziek uit te voeren in de notatie van elkaar losgekoppeld zijn. Dit heet ook wel physical polyphonic notations, een unieke en relatief recente trend in de muziek waarbij naast de noten…
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Waves and Patterns in Discrete Media: Bridging the Gaps
What happens to electrical waves that have to cross gaps in insulation material around nerves in the human body
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Islam en het Westen
Moslims leven al sinds eeuwen in Oost- en Zuidoost Europa. Hun komst naar West-Europa en de twee Amerika’s en Australië is echter recent. Het bestuderen van de manier waarop moslims zich verhouden tot hun Westerse omgeving (en vice versa), en van de wederzijdse beïnvloeding van Westers en islamitisch…
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Aandacht voor de bloed-hersenbarrière door en voor neurowetenschappers uit Nederland
Als onderdeel van Brain Awareness Week 2013, organiseert BBBNedwork op vrijdag 22 maart haar kick-off meeting in Leiden. Op dit symposium zullen verschillende (neuro)wetenschappers samenkomen om de centrale rol van de bloed-hersenbarrière in de behandeling van hersenaandoeningen te bespreken.
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Molecular mystery in space
The space between the stars isn't simply a void; it also contains substances such as methanol and carbon dioxide. So far, chemical theories have been unable to explain how these substances originate under circumstances that should make it impossible. Fedor Goumans has been awarded a Veni subsidy to…