In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Promotie

Promotores: G.W. Canters, T.J. Aartsma

Promotor: Prof.dr. M.A.G.J. Orrit

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

This thesis presents the anharmonic infrared spectra of a series of polycyclic aromatic hydrocarbons. Comparisons and characterizations are made based on high-resolution low-temperature gas-phase experimental spectra.

Promotie

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Promotie

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.

Promotie

Promotie

Promotie

Promotie

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Promotie

Promotie

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

Lezing

Lezing

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Promotor: Prof.dr. M. Ubbink

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Promotie

Promotie

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

Wiskunde en Natuurwetenschappen

Lezing

Mede dankzij de Leidse hoogleraar Michel Orrit is het tegenwoordig mogelijk om losse moleculen te bestuderen. Hij liep de Nobelprijs net mis, maar wordt nu alsnog gelauwerd met een belangrijke wetenschappelijke onderscheiding. Op 16 juni ontvangt hij de Spinozapremie van NWO.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Milan Allan heeft de Bryan R. Coles Prize gewonnen op de International Conference on Strongly Correlated Electron Systems (SCES) in Praag.

In een Advance Online Publication in Nature Structural & Molecular Biology laten biofysicus John van Noort en anderen zien dat DNA gevouwen zit in flexibele spiralen van chromatine. De onderzoeksgroep van Van Noort ontdekte dit in nauwe samenwerking met onderzoekers uit Cambridge. Het artikel met de…