526 zoekresultaten voor “single cell transcriptomics” in de Publieke website
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NGL lezing: Single molecules and single gold nanoparticles in the spotlight
Lezing
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B cell modulation in atherosclerosis
Promotie
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Origami metamaterials : design, symmetries, and combinatorics
In the first part of this thesis we study the geometry of folding patterns.
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Exploring Deep Learning for Intelligent Image Retrieval
This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.
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The ambiguous beta-cell
Promotie
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
Promotie
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Orrit ontvangt OTP subsidie van NWO-TTW
Michel Orrit heeft een subsidie ontvangen uit het NWO-TTW Open Technologieprogramma. Hij gaat de kleine half miljoen euro gebruiken om individuele moleculen in beeld te brengen zonder fluorescentie te gebruiken.
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Control of cytomegalovirus viremia after T cell depleted allogeneic stem cell transplantation
Promotie
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T-Control: T-Cell Therapy in the Context of Allogeneic Stem Cell Transplantation
Promotie
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of metabolic pathways and sensors in regulation of dendritic cell- driven T cell responses
Promotie
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Hot Nanoparticles
Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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enhancement of one-photon- and two-photon-excited single-molecule fluorescence by single gold nanorods
Promotie
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Photothermal circular dichroism studies of single nanoparticles
Promotie
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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CO2 reduction on post-transition metals and their alloys: an industrial approach
This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals
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The role of autophagy during carbon starvation in Aspergillus niger
Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.
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Software
Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements
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Towards Optical Detection of a Single Electron
Promotie
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Full professor in Discovery of Biologics
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Postdoctoral Research Associate in the mechanics of living materials
Wiskunde en Natuurwetenschappen
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Michel Orrit ontvangt Spinozaprijs in Koninklijke Schouwburg
Op 12 september heeft Michel Orrit zijn Spinozaprijs in ontvangst genomen uit handen van OCW staatssecretaris Sander Dekker in de Koninklijke Schouwburg in Den Haag. Met de prijs is een premie gemoeid van 2,5 miljoen euro, die vrij is te besteden aan wetenschappelijk onderzoek naar keuze, en het felbegeerde…
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Langerhans Cell Histiocytosis; Genetic and Immunologic Fingerprinting
Promotie
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Mesenchymal Stromal Cell in Pediatric Disease
Promotie
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Mesenchymal stromal cell treatment for COPD
Promotie
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?
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Human T-cell responses to Aspergillus fumigatus
Promotie
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Effects of heavy fields on inflationary cosmology
Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten
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Optical properties of DNA-hosted silver clusters
Promotor: D. Bouwmeester, Co-promotor: D. Kraft
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De nanowereld visualiseren
Eiwitten in cellen visualiseren zonder invasieve technieken? Dat kan met behulp van fluorescentie. Michel Orrit, winnaar van de Spinozapremie 2017 én grondlegger van het vakgebied single molecule optics, legde op 18 januari aan de leden van het Natuurwetenschappelijk Gezelschap Leiden en andere geïnteresseerden…
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Taking control of charge transfer: strategic design for solar cells
Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Ecological functioning of bacterial chitinases in soil
Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)
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Trans-kingdom DNA transfer
The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.
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Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Towards understanding the toxicity of copper nanoparticles in aquatic ecosystems
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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The role of the interleukin 12 family in atherosclerosis
Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager
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The role of the Arabidopsis AHL15/REJUVENATOR gene in developmental phase transitions
This thesis describes the functional analysis of the Arabidopsis AHL15 gene.
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum
The applications of studying the early development of insects range from agriculture to material science.
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The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
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Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.