This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

In this course you will develop an understanding of evolutionary processes and their formative power. You will see how evolution has shaped biodiversity, and continuously influences our daily life.

Galaxies in the local Universe fall into two main categories of spirals and ellipticals. In this Thesis, we explore the structural evolution of galaxies into this bimodal distribution.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L.B.F.M. Waters (UvA), Prof.dr. C. Dominik (UvA)

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Sustainable energy from wind and solar is most readily available near the sea.

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Promotor: Prof.dr. M. Schilthuizen

Promotor: Prof.dr. H.J.A. Rottgering

One of the most important puzzles in modern astrophysics is the nature of dark matter.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Promotor: H.J.A. Rottgering, Co-Promotor: R.J. van Weeren

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

Planets are formed in disks of gas and dust around young stars.

This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Promotor: Prof.dr. E.F. Smets

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

Promotor: Prof.dr. E.F. van Dishoeck

The logic seems inescapable indeed. The bigger the population, the higher the probability it contains an Einstein. Hence, bigger populations are more likely to develop complex culture.

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

The origin and evolution of galaxies are closely linked to many different physical phenomena.

Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Evolutie is elke dag om je heen. Dat is de boodschap van de nieuwe Massive Open Online Course (MOOC) van de Universiteit Leiden en Naturalis die 19 september van start gaat.

Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.