The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: Prof.dr. P. Hooykaas, Co-promotor: R. Offringa

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

Heart failure is a major health care problem with high mortality.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Promotores: A.H. Meijer, H.P. Spaink

Handbook of Signal Processing Systems is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications;…

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Promotor: B. van de Water

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Promotor: J. A. Bouwstra

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Het is onderzoekers voor het eerst gelukt grafeen op een stabiele laag vetten, ofwel lipiden, te plaatsen. Omringd door een beschermende laag van lipiden zou grafeen in het lichaam als een veelzijdige sensor kunnen dienen. De resultaten zijn de eerste stap naar zo’n omhulsel en zijn op 28 september…

Promotie

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

Promotor: A. Kros

We consider the propagation of electrical signals through nerve fibres.

Farmacoloog Walter Boiten ontwikkelde een nieuwe methode om de hoeveelheid vetten in iemands huid te kunnen bepalen. Met de methode testte hij de effecten van een nieuwe crème die hij ontwikkelde voor eczeempatiënten. De eerste resultaten zijn veelbelovend. Boiten promoveert op 15 januari.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotor: A. Kros

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Promotie

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Promotie

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…