Developing methodes to understand the evolution of patches in natural ecosystems

Unfolding potential

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Veel kinderen leren niet op een niveau dat aansluit bij hun potentieel om te leren. Diagnostiek in de leerlingbeleiding zou daarom inzicht moeten geven in hoe een kind begeleid kan worden in het verder ontwikkelen van zijn of haar sterke kanten terwijl het tegelijkertijd handvatten biedt voor het ondersteunen…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: W.Th.F. den Hollander

Promotor: J.W. van Holten

An assessment approach that tailors to children’s instructional needs

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Hoe beinvloed de structuur van één enkel gen de activiteit van genen die gevoelig zijn voor hormonen?

Het artikel 'Flexible updating of dynamic knowledge structures' met bijdrage van Franziska Richter van Cognitieve Psychologie is uitgebracht door Nature.

Robert Kirkpatrick, directeur van UN Global Pulse, bezocht de Faculteit der Wiskunde en Natuurwetenschappen op dinsdag 27 oktober 2015.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Promotor: Prof.dr. G.J. Kroes

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Remus Dame

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Unconstrained day-to-day activities are difficult to quantify and how the corresponding movements shape the brain remain unclear. Read more

De negende Network Europe Conference in Edinburgh werd in juni 2017 gehouden en was georganiseerd door het Europa Instituut in Zurich.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)